1. [Abnormal hemoglobins identified in Martinique].
- Author
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Monplaisir N, Galacteros F, Arous N, Rhoda MD, Delanoe-Garin J, Ouka-Montjean M, de Linval JC, and Rosa J
- Subjects
- Epidemiologic Methods, Hemoglobin C isolation & purification, Hemoglobin, Sickle isolation & purification, Hemoglobins, Abnormal genetics, Humans, Infant, Newborn, Isoelectric Focusing, Martinique, Phenotype, Sickle Cell Trait blood, Thalassemia blood, Hemoglobins, Abnormal isolation & purification
- Abstract
Epidemiologic programs in Martinique during the last 10 years and particularly the last 5, have allowed the determination of the Hb S, Hb C, beta thalassemia traits frequencies. A number of rare variants have been detected during the course of these screening programs. Many of these Hb variants have been analysed at the structural level. For some of them a pathologic interaction with Hb S is observed (Hb D Punjab, Hb O Arab...), and the use of electrophoretic mobilities obtained with the reference samples provides the basis of a rapid, highly probable presumptive identification and then, a useful tool, when for example genetic counselling is necessary.
- Published
- 1985