1. Pralidoxime as an insignificant reactivator in severe anticholinesterase (organophosphate insecticide) poisoning.
- Author
-
Ganendran A and Balabaskaran S
- Subjects
- Acetylthiocholine, Atropine therapeutic use, Butyrylthiocholine, Dose-Response Relationship, Drug, Humans, Malaysia, Pralidoxime Compounds therapeutic use, Cholinesterase Inhibitors, Enzyme Reactivators, Insecticides poisoning, Organophosphorus Compounds, Pralidoxime Compounds pharmacology
- Abstract
In acute severe anticholinesterase poisoning by organophosphate compounds, pralidoxime (P-2-AM, pyridine-2-aldoxime methiodide) used in the recommended doses, intravenously, has not been shown to reactivate the inhibited cholinesterase, as evidenced both clinically and biochemically. In vitro studies using pralidoxime iodide up to ten times the recommended concentrations, produced insignificant reactivation of cholinesterases inhibited by the organophosphate insecticide Bidrin (di-methyl-3-hydroxyl-N, N-dimethyl-crotonamide phosphate). This was even so despite prolonged exposure of the inhibited cholinesterases to the oxime. The value of pralidoxime as a reactivator of phosphorylated cholinesterases is therefore in doubt, and should not be used in preference to large doses of atropine and other supportive treatment in poisoning by organophosphate insecticides.
- Published
- 1976