1. Limited geographic distribution of the novel cyclovirus CyCV-VN.
- Author
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Le VT, de Jong MD, Nguyen VK, Nguyen VT, Taylor W, Wertheim HF, van der Ende A, van der Hoek L, Canuti M, Crusat M, Sona S, Nguyen HU, Giri A, Nguyen TT, Ho DT, Farrar J, Bryant JE, Tran TH, Nguyen VV, and van Doorn HR
- Subjects
- Adult, Base Sequence, Central Nervous System Infections cerebrospinal fluid, Central Nervous System Infections epidemiology, Child, Circoviridae classification, Circoviridae isolation & purification, Circoviridae Infections cerebrospinal fluid, Circoviridae Infections virology, DNA, Viral genetics, Female, Genetic Variation, Genome, Viral, Geography, Humans, Malawi epidemiology, Male, Molecular Sequence Data, Sequence Alignment, Sequence Analysis, DNA, Vietnam epidemiology, Central Nervous System Infections virology, Circoviridae genetics, Circoviridae Infections epidemiology
- Abstract
A novel cyclovirus, CyCV-VN, was recently identified in cerebrospinal fluid (CSF) from patients with central nervous system (CNS) infections in central and southern Vietnam. To explore the geographic distribution of this novel virus, more than 600 CSF specimens from patients with suspected CNS infections in northern Vietnam, Cambodia, Nepal and The Netherlands were screened for the presence of CyCV-VN but all were negative. Sequence comparison and phylogenetic analysis between CyCV-VN and another novel cyclovirus recently identified in CSF from Malawian patients indicated that these represent distinct cycloviral species, albeit phylogenetically closely related. The data suggest that CyCV-VN has a limited geographic distribution within southern and central Vietnam. Further research is needed to determine the global distribution and diversity of cycloviruses and importantly their possible association with human disease.
- Published
- 2014
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