1. Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest.
- Author
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Liu Y, Young K, Rakotondraibe LH, Brodie PJ, Wiley JD, Cassera MB, Callmander MW, Rakotondrajaona R, Rakotobe E, Rasamison VE, TenDyke K, Shen Y, and Kingston DG
- Subjects
- 4-Butyrolactone analogs & derivatives, 4-Butyrolactone chemistry, Antineoplastic Agents, Phytogenic chemistry, Cell Proliferation drug effects, Dioxoles chemistry, Drug Screening Assays, Antitumor, Forests, HCT116 Cells, Humans, Inhibitory Concentration 50, Lignans chemistry, Madagascar, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plant Leaves chemistry, Plasmodium falciparum drug effects, Stereoisomerism, Antineoplastic Agents, Phytogenic isolation & purification, Antineoplastic Agents, Phytogenic pharmacology, Lignans isolation & purification, Lignans pharmacology, Malpighiaceae chemistry
- Abstract
The two new lignans 3α-O-(β-D-glucopyranosyl)desoxypodophyllotoxin (1) and 4-O-(β-D-glucopyranosyl)dehydropodophyllotoxin (2) were isolated from Cleistanthus boivinianus, together with the known lignans deoxypicropodophyllotoxin (3), (±)-β-apopicropodophyllin (4), (-)-desoxypodophyllotoxin (5), (-)-yatein (6), and β-peltatin-5-O-β-D-glucopyranoside (7). The structures of all compounds were characterized by spectroscopic techniques. Compounds 1, 4, and 5 showed potent antiproliferative activities against the A2780 ovarian cancer cell line, with IC50 values of 33.0 ± 3.6, 63.1 ± 6.7, and 230 ± 1 nM, respectively. Compounds 2 and 7 showed only modest A2780 activities, with IC50 values of 2.1 ± 0.3 and 4.9 ± 0.1 μM, respectively, while compounds 3 and 6 had IC50 values of >10 μM. Compound 1 also had potent antiproliferative activity against the HCT-116 human colon carcinoma cell line, with an IC50 value of 20.5 nM, and compound 4 exhibited modest antiproliferative activity against the A2058 human caucasian metastatic melanoma and MES-SA human uterine sarcoma cell lines, with IC50 values of 4.6 and 4.0 μM, respectively.
- Published
- 2015
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