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Farmers utilize pesticides extensively on their farms to control weeds and insects, as well as increase crop productivity. Despite these advantages, their excessive use poses a serious threat, particularly to the population living at the nexus of urban and rural areas. Exposure to pesticide drift can be investigated using geospatial tools. Remote sensing technology and Geographic Information Systems (GIS) techniques have been used intensively and constitute trusted tools in different sectors, especially in agriculture. Remote sensing depends on processing the electromagnetic radiation reflected and emitted from the ground target and can be used to identify the main units of Land Use Land Cover (LULC), in addition to measuring crop areas exposed to pesticides. GIS has powerful tools for building a spatial geo-database of pesticide exposure drift. Therefore, the major objective of the research was to explore the effectiveness of using remote sensing and GIS techniques to estimate the exposure organophosphate pesticides drift over Macon County, Alabama. To achieve this objective, the Cropland Data Layer (CDL) dataset, the available pesticide usage data, and gridded population data were used to estimate the potential pesticide drift on the Macon County level. In addition, the AgDRIFT model was used to estimate the potential drift of pesticides from their intended targets at the field level. The results indicated that 6.6% of Macon County's residents are considered potentially severely exposed, and the potentially affected population resides primarily in rural areas. In comparison, 23% of residents of the urban-rural interface are considered to have potentially medium to high exposure. In addition, 38% of residents living in suburban areas are considered to have potentially low-to-medium exposure. The results indicated that both GIS and remote sensing could play an effective role in estimating pesticide exposure drift at the State or County level. In addition, the AgDRIFT model was more appropriate for estimating pesticide drift at the field level. [ABSTRACT FROM AUTHOR]