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Abstract: Lead (Pb) poisoning causes permanent neurologic and developmental disorders and remains an important environmental health problem for US children, despite removal of Pb from gasoline and household paints. To better understand the contribution of Pb from historical traffic and residential Pb based paint to soil Pb concentrations in Los Angeles, we analyzed 550 soil Pb samples from south central Los Angeles County, CA, in relation to land-use patterns (commercial, industrial, residential, and parks and open areas) and proximity to freeways, highways, and major arterials. House age variables (surrogates of historical Pb-based paint) and traffic index variables (surrogates of historical traffic) were created at different buffer distances (10–5000m). Total and bioavailable Pb concentrations near freeways and major arterials were significantly higher than those collected elsewhere. Total and bioavailable Pb concentrations were highly correlated (r=0.96) after the removal of one outlier. Both parcel-age related variables and traffic variables were important predictors of current soil bioavailable Pb concentrations. Average age of parcels within 30m and length of small streets within 3000m explained 57% and 38% of the variance, respectively, in soil bioavailable Pb concentrations in residential areas away from freeways and major arterials (N=44). Road length of freeways within 750m explained 28% of bioavailable Pb concentrations in parks and open areas (N=26). Multi-variable regression models predicted 16–61% of the variances in bioavailable Pb concentrations, depending on land-use type and spatial relationship to roadways. Based on these models a map of spatial distributions of soil Pb concentrations was created for the Los Angeles area that shows promise as a screening tool to evaluate continued Pb poisoning in children. [Copyright &y& Elsevier]

Light rail transit (LRT) systems constitute one of the most sustainable public transportation modes and transit agencies have increasingly constructed LRT lines along the median of roadways to reduce land acquisition costs and traffic conflicts. Despite these conveniences, few studies have examined the air pollution and noise exposures for passengers on LRT station platforms within freeway or arterial medians. In response, we monitored particle number count (PNC) concentrations and noise levels on 17 station platforms in the Los Angeles metro system in summer 2012 and assessed differences between freeway and arterial platforms. We visited each station on average 7 times for approximately 19 min with two teams carrying a full set of instruments. As expected, impacts were higher on green line platforms in the center of a grade-separated freeway compared to blue line platforms in the center of an arterial due to being in close proximity to greater traffic volumes. Overall, freeway-arterial platform differences were 35,100 versus 20,000 particles/cm 3 for PNC and 83 versus 62 dBA for noise. This average noise intensity on green line platforms was four times that on blue line stations. We also found that PNC concentrations were significantly higher at open air monitoring platform positions compared to standing under a shade canopy (about 2000 particles/cm 3 higher), but that noise levels were significantly lower at open air positions compared to under canopy positions (about 3.2 dBA lower). Results identify important factors for transport planners to consider when locating and designing in-roadway LRT platforms. [ABSTRACT FROM AUTHOR]

Gestational diabetes mellitus (GDM) is a major pregnancy complication affecting approximately 14.0% of pregnancies around the world. Air pollution exposure, particularly exposure to PM 2.5 , has become a major environmental issue affecting health, especially for vulnerable pregnant women. Associations between PM 2.5 exposure and adverse birth outcomes are generally assumed to be the same throughout a large geographical area. However, the effects of air pollution on health can very spatially in subpopulations. Such spatially varying effects are likely due to a wide range of contextual neighborhood and individual factors that are spatially correlated, including SES, demographics, exposure to housing characteristics and due to different composition of particulate matter from different emission sources. This combination of elevated environmental hazards in conjunction with socioeconomic-based disparities forms what has been described as a "double jeopardy" for marginalized sub-populations. In this manuscript our analysis combines both an examination of spatially varying effects of a) unit-changes in exposure and examines effects of b) changes from current exposure levels down to a fixed compliance level, where compliance levels correspond to the Air Quality Standards (AQS) set by the U.S. Environmental Protection Agency (EPA) and World Health Organization (WHO) air quality guideline values. Results suggest that exposure reduction policies should target certain "hotspot" areas where size and effects of potential reductions will reap the greatest rewards in terms of health benefits, such as areas of southeast Los Angeles County which experiences high levels of PM 2.5 exposures and consist of individuals who may be particularly vulnerable to the effects of air pollution on the risk of GDM. • Study examines effects of PM 2.5 exposure reduction on incidence of Gestational diabetes mellitus (GDM).· Analyses address issues related to "double jeopardy" for marginalized sub-populations.· Results suggest that interventions should target areas containing both high exposure and elevated SES-based vulnerabilities. • Effects of reducing PM 2.5 exposure down to fixed compliance levels are examined. • Analyses address issues related to "double jeopardy" for marginalized sub-populations. • Results suggest that interventions should target areas containing both high exposures and elevated SES-based vulnerabilities. [ABSTRACT FROM AUTHOR]

Background Low birth weight (LBW, <2500 g) has been associated with exposure to air pollution, but it is still unclear which sources or components of air pollution might be in play. The association between ultrafine particles and LBW has never been studied. Objectives To study the relationships between LBW in term born infants and exposure to particles by size fraction, source and chemical composition, and complementary components of air pollution in Los Angeles County (California, USA) over the period 2001–2008. Methods Birth certificates ( n =960,945) were geocoded to maternal residence. Primary particulate matter (PM) concentrations by source and composition were modeled. Measured fine PM, nitrogen dioxide and ozone concentrations were interpolated using empirical Bayesian kriging. Traffic indices were estimated. Associations between LBW and air pollution metrics were examined using generalized additive models, adjusting for maternal age, parity, race/ethnicity, education, neighborhood income, gestational age and infant sex. Results Increased LBW risks were associated with the mass of primary fine and ultrafine PM, with several major sources (especially gasoline, wood burning and commercial meat cooking) of primary PM, and chemical species in primary PM (elemental and organic carbon, potassium, iron, chromium, nickel, and titanium but not lead or arsenic). Increased LBW risks were also associated with total fine PM mass, nitrogen dioxide and local traffic indices (especially within 50 m from home), but not with ozone. Stronger associations were observed in infants born to women with low socioeconomic status, chronic hypertension, diabetes and a high body mass index. Conclusions This study supports previously reported associations between traffic-related pollutants and LBW and suggests other pollution sources and components, including ultrafine particles, as possible risk factors. [ABSTRACT FROM AUTHOR]

[Display omitted] Within the Multiethnic Cohort (MEC), we examined the association between air pollution and mortality among African American, European American, Japanese American, and Latina American women diagnosed with breast cancer. We used a land use regression (LUR) model and kriging interpolation to estimate nitrogen oxides (NO x , NO 2) and particulate matter (PM 2.5 , PM 10) exposures for 3,089 breast cancer cases in the MEC, who were diagnosed from 1993 through 2013 and resided largely in Los Angeles County, California. Cox proportional hazards models were used to examine the association of time-varying air pollutants with all-cause, breast cancer, cardiovascular disease (CVD), and non-breast cancer/non-CVD mortality, accounting for key covariates. We identified 1,125 deaths from all causes (474 breast cancer, 272 CVD, 379 non-breast cancer/non-CVD deaths) among the 3,089 breast cancer cases with 8.1 years of average follow-up. LUR and kriged NO X (per 50 ppb) and NO 2 (per 20 ppb), PM 2.5 (per 10 µg/m3), and PM 10 (per 10 µg/m3) were positively associated with risks of all-cause (Hazard Ratio (HR) range = 1.13–1.25), breast cancer (HR range = 1.19–1.45), and CVD mortality (HR range = 1.37–1.60). Associations were statistically significant for LUR NO X and CVD mortality (HR = 1.60; 95% CI: 1.08–2.37) and kriged NO 2 and breast cancer mortality (HR = 1.45; 95% CI 1.02–2.07). Gaseous and PM pollutants were positively associated with breast cancer mortality across racial/ethnic group. In this study, air pollutants have a harmful impact on breast cancer survival. Additional studies should evaluate potential confounding by socioeconomic factors. These data support maintaining clean air laws to improve survival for women with breast cancer. [ABSTRACT FROM AUTHOR]