1. Microbial keratitis in los angeles: the doheny eye institute and the los angeles county hospital experience.
- Author
-
Sand D, She R, Shulman IA, Chen DS, Schur M, and Hsu HY
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Bacteria drug effects, Child, Ciprofloxacin pharmacology, Ciprofloxacin therapeutic use, Corneal Ulcer drug therapy, Corneal Ulcer microbiology, Eye Infections, Bacterial drug therapy, Eye Infections, Bacterial microbiology, Female, Gram-Negative Bacterial Infections drug therapy, Gram-Negative Bacterial Infections microbiology, Gram-Positive Bacterial Infections drug therapy, Gram-Positive Bacterial Infections microbiology, Hospitals, County statistics & numerical data, Humans, Levofloxacin pharmacology, Levofloxacin therapeutic use, Los Angeles epidemiology, Male, Microbial Sensitivity Tests, Middle Aged, Retrospective Studies, Corneal Ulcer epidemiology, Eye Infections, Bacterial epidemiology, Gram-Negative Bacterial Infections epidemiology, Gram-Positive Bacterial Infections epidemiology
- Abstract
Objective: To evaluate the spectrum and antibiotic susceptibility panel of infectious keratitis at a major tertiary care referral eye center and a major county hospital in Southern California., Design: Retrospective case series., Participants: All cultured infectious keratitis cases from July 1, 2008, through December 31, 2012, from the Doheny Eye Institute (DEI) and the Los Angeles County + University of Southern California Medical Center (LAC+USC) were evaluated., Methods: Microbiology records were reviewed retrospectively., Main Outcome Measures: Microbial isolates as well as antibiotic susceptibility patterns were analyzed., Results: One hundred eighty-four (63%) of 290 cases showed positive culture results at DEI and 152 (82%) of 186 cases showed positive culture results at LAC+USC. Gram-positive pathogens were found to be the most common at both DEI (70%) and LAC+USC (68%), with coagulase-negative Staphylococcus being the most common gram-positive organism (58% at DEI and 44% at LAC+USC). Pseudomonas aeruginosa was the most common gram-negative organism (57% at DEI and 43% at LAC+USC). Ciprofloxacin and levofloxacin susceptibility for all tested pathogens was 73% at DEI and 81% at LAC+USC (P = 0.16). Oxacillin-resistant Staphylococcus aureus (ORSA) was found in 42% of cases at DEI and in 45% of cases at LAC+USC (P = 1.00)., Conclusions: There is no significant difference in the spectrum of pathogens or antibiotic susceptibility of pathogens at DEI versus LAC+USC, and ORSA was found in approximately half of all S. aureus samples., (Copyright © 2015 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2015
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