1. Vascular Abnormalities, Paraoxonase Activity, and Dysfunctional HDL in Primary Antiphospholipid Syndrome.
- Author
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Charakida, Marietta, Besler, Christian, Batuca, Joana R., Sangle, Shirish, Marques, Susanna, Sousa, Miguel, Wang, Guosu, Tousoulis, Dimitris, Alves, Jose Delgado, Loukogeorgakis, Stavros P., Mackworth-Young, Charles, D'Cruz, David, Luscher, Thomas, Landmesser, Ulf, and Deanfield, John E.
- Subjects
PHOSPHOLIPID antibodies ,WOMEN'S health ,ANTIPHOSPHOLIPID syndrome ,PARAOXONASE - Abstract
The article details a study which compared the vascular structure and function between patients with positive antiphospholipid antibodies (aPL) and a control group. The study also assessed the relationship of vascular structure and function with paraoxonase activity. It included 77 women with positive aPL from a lupus outpatient clinic in London, England and 77 controls. Women with positive aPL were found to have greater carotid intima media thickness (CIMT) and pulse wave velocity compared to control. Study authors concluded that higher functional structural arterial abnormalities in aPL positive women is associated with lower activity of paraoxonase.
- Published
- 2009
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