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In order to adapt to an increasingly competitive world, organizations need to continuously change, yet the success of the change is conditioned by its institutionalization. The institutionalization of change is the key factor to perpetuate sustainable changes. Based on the exploration of the role of transformational leadership in times of (institutionalization of) change, the objective of this study is to analyze the contribution of the components of transformational leadership on the institutionalization of change within a Lebanese private university Redundancy, engaged in an accreditation process. Through a qualitative method on a single case study, based on semi-structured interviews conducted with 15 senior executives occupying key positions in the studied university and through 15 focus groups with 85 faculty members from four disciplinary fields, we explored the role of each of the four dimensions of transformational leadership in times of institutionalization of change. Our findings highlight the essential role of intellectual stimulation and inspirational motivation of transformational leadership, while the two other dimensions, idealized influence and individualized consideration, play a limited role in the university context of institutionalization of change. Moreover, individual recognition and idealized influence are essential to convince all members of the need for change and involve them in the accreditation process. This study allows us to understand the role of each of the transformational leadership dimensions in order to promote and escort institutionalization of change within high education sector.

Anticoagulant rodenticides (AR) remain the most effective chemical substances used to control rodents in order to limit their agricultural and public health damage in both rural and urban environments. The emergence of genetically based resistance to AR worldwide has threatened effective rodent control. This study gives a first overview of the distribution and frequency of single nucleotide polymorphism in the vitamin K epoxide reductase subcomponent 1 (Vkorc1) gene in rodents in Lebanon. In the Mus genus, we detected two missense mutations Leu128Ser and Tyr139Cys, that confer resistance to anticoagulant rodenticides in house mice and a new missense mutation Ala72Val in the Mus macedonicus species, not previously described. In the Rattus genus, we found one missense mutation Leu90Ile in the roof rat and one missense mutation Ser149Ile in the Norway rat. This is the first study to demonstrate potential resistance to AR in Lebanese rodents and therefore it provides data to pest control practitioners to choose the most suitable AR to control rodents in order to keep their efficacy. [ABSTRACT FROM AUTHOR]

This cross‐sectional study was conducted to determine the prevalence of Salmonella at different stages of the broiler production chain and layer flocks in addition to their antibiotic resistance profile and molecular patterns. Over a period of 3 years, different sample matrices were collected from Lebanese farms, slaughterhouses and retail markets. Out of 672 Salmonella serotyped, 514 were analysed for antimicrobial resistance and 214 for clonality using Pulsed‐field gel electrophoresis (PFGE). The results highlighted an important prevalence of Salmonella, 30% in farms, 35.8% in slaughterhouses and 22.4% at retail level. A large diversity of serotypes was identified with predominance among Salmonella Infantis (32.9%), Salmonella Enteritidis (28.4%) and Salmonella Kentucky (21.4%). High resistance to nalidixic acid was revealed in all the isolates. The most prominent resistance was exhibited in S. Kentucky and S. Infantis. The latter was resistant to tetracycline (99%), streptomycin (88.2%) and remarkable multi‐drug resistance (MDR) (89.7%). All S. Kentucky isolates were resistant to ciprofloxacin, MDR (62.4%) and 6% were resistant to extended‐spectrum cephalosporin (ESCs). One persistent clone of S. Enteritidis was found common between poultry and humans. Similar genomic profiles were detected between farms, slaughterhouses and retail suggesting the dissemination of identical clones throughout the food chain possibly due to weak barriers preventing such transmission. [ABSTRACT FROM AUTHOR]

The use of polluted water to irrigate is an increasing problem in the developing world. Lebanon is a case in point, with heavily polluted irrigation waters, particularly in the Litani River Basin. This study evaluated the potential health risks of irrigating vegetables (radishes, parsley, onions, and lettuce) using three water sources (groundwater, river water, and treated wastewater) and three irrigation methods (drip, sprinkler, and surface) over two growing seasons in 2019 and 2020. Water, crop, and soil samples were analyzed for physicochemical parameters, pathogens, and metals (Cu, Cd, Ni, Cr, and Zn). In addition, the bioaccumulation factor, estimated dietary intakes, health risk index, and target hazard quotients were calculated to assess the health risk associated with metal contamination. The study showed that, for water with less than 2 log E. coli CFU/100 mL, no pathogens (Escherichia coli, salmonella, parasite eggs) were detected in irrigated vegetables, irrespective of the irrigation method. With over 2 log E. coli CFU/100 mL in the water, 8.33% of the sprinkler-and surface-irrigated vegetables, and 2.78% of the drip-irrigated root crops (radishes and onions), showed some degree of parasitic contamination. E. coli appeared only on root crops when irrigated with water having over 3 log CFU/100 mL. The concentrations of most metals were significantly lower than the safe limits of the FAO/WHO of the Food Standards Programme Codex, except for zinc and chromium. The trends in the bioaccumulation factor and the estimated dietary intakes of metals were in the order of Cu < Cd < Ni < Cr < Zn. The target hazard quotient values for all metals were lower than 1.0. Under trial conditions, the adoption of drip irrigation with water with less than 3 log E. coli CFU/100 mL proved to be safe, even for vegetables consumed raw, except for root crops such as onions and radishes that should not be irrigated with water having over 2 log E. coli CFU/100 mL. Treated wastewater had no adverse effect on vegetable quality compared to vegetables irrigated with other water sources. These results support efforts to update the Lebanese standards for water reuse in agriculture; standards proposed in 2011 by the FAO, and currently being reviewed by the Lebanese Institution of Standards. This research will inform a sustainable water management policy aimed at protecting the Litani River watershed by monitoring water quality. [ABSTRACT FROM AUTHOR]

Purpose: Lebanon has witnessed an increase in the rates of several cancer subtypes over the last years. The aim of this study is to examine the incidence rates of kidney cancer in Lebanon over 12 years and to compare them to other countries. Methods: Data were collected from the Lebanese National Cancer Registry (NCR) for the time period 2005–2016 (inclusive). Data from other countries were retrieved from an online database "Cancer Incidence in Five Continents." The age specific and age-standardized rates (ASR) were calculated and analyzed using Joinpoint regression. Results: Kidney cancer ranked as the 10th commonest cancer among men and the 19th among women. An age-standardized rate of 3.54 (per 100,000) was obtained. The average ASR was 4.80 for men and 2.27 for women. Kidney cancer showed a significantly rising trend for both genders. Lebanon had the highest ASR for kidney cancer in men and the third highest in women among regional countries. Conclusion: Lebanon presented an average-to-high ASR for kidney cancer compared to regional countries. However, compared to countries worldwide, Lebanon had a below-average ASR. Nonetheless, with the rising kidney cancer trends, it is important to study the associated risk factors in order to develop proper preventive and screening measures and therefore decrease the incidence rates. [ABSTRACT FROM AUTHOR]

Copyright of Parasite (1252607X) is the property of EDP Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Basketball is the most popular sport in Lebanon. Adequate nutrition has been established to be a key component of optimal athletic performance, recovery from exercise and exercise-induced injury and documented to be associated with adequate nutrition knowledge (NK). In Lebanon, nutrition education is not incorporated into the basketball player training program and there is no established position for sports nutritionists in basketball clubs. To our knowledge, the present study is the first to evaluate the NK status of Division I Basketball (D1B) players /coaches in Lebanon. The objectives of this study are to assess the prevalence of inadequate NK; identify the gaps in NK, main sources of nutrition information, perceptions on sports nutrition and independent predictors of inadequate NK among D1B players and coaches in Lebanon. Methods: All D1B players (n = 184) and coaches (n = 16) in Lebanon were invited to participate in the study. Study participants were asked to complete a questionnaire that included questions on NK, resources and perceptions. A percentage of ≥60% of NK questions answered correctly was used as indicative of having adequate NK. Descriptive statistics were used to summarize the sample characteristics. The T-test and chi square test were used for comparisons of means and proportions, respectively. Logistic regression was used to explore the predictors of inadequate NK in D1B players. Results: The sample consisted of 178 D1B players (nM = 126; nF = 52) and 11 male coaches, resulting in survey response rates of 97 and 69%, respectively. Inadequate NK was found among about 80 and 54% of D1B players and coaches, respectively. Inadequate NK was found to be independently associated with lack of nutrition education in D1B players. Conclusions: Despite widespread lack of adequate NK among D1B players and coaches in Lebanon, our sports clubs do not have dietitians. Basketball sports clubs in Lebanon should start to budget for hiring a dietitian or carrying out nutrition education campaigns that are based on analyses of incorrect responses of our study participants. Findings of this study are of tremendous significance to D1B players in Lebanon in terms of improving the athletes' physical health and performance. [ABSTRACT FROM AUTHOR]

Origanum ehrenbergii Boiss, endemic to Lebanon, is widely used in culinary preparations. The aim of this study is to assess the chemical composition and biological activities of four extracts obtained by consecutive extractions with four different solvents presenting an increasing polarity (cyclohexane, dichloromethane, ethyl acetate, and methanol). HPLC‐DAD analysis revealed nine compounds with 8 phenolics, while GC‐MS analysis allowed to detect 96 volatile compounds. Among the latter, some compounds were identified for the first time in plant extracts such as 2‐allyl‐phenyl tiglate (26); 2‐furylmethyl octanoate (28); 1H‐cycloprop[e]azulen‐7‐ol,decahydro‐1,1,7‐trimethyl‐4‐methylene‐,[1ar‐(1aα,4aα,7β,7aβ,7bα)] (30); 2‐(Z)‐propenylphenyl tiglate (32); 6‐hydroxy‐4,4,7a‐trimethyl‐5,6,7,7a‐tetrahydrobenzofuran‐2(4H)‐one (33); ent‐beyerane (37); and (E)‐2‐tridecenyl angelate (40). The methanol extract had the highest antioxidant activity with an IC50 of 37.5 μg/mL. It also had the highest phenolic content with 207.2 mg of gallic acid equivalents (GAE)/g of dry weight. The inhibition percentage of the acetylcholinesterase by the methanol extract (56.9%), the ethyl acetate extract (58.6%), and the cyclohexane extract (60.0%) was almost the same at 50 µg/mL. Furthermore, the dichloromethane extract inhibited both the growth of the MCF‐7 cell line by 67.0% and HCT‐116 cell line by 35.7% at 50 μg/mL. The MIC of the dichloromethane extract against Listeria monocytogenes ATCC 19 115 and Listeria monocytogenes isolated from "fish filet" was 4 and 15 μg/mL, respectively, and that of the cyclohexane extract against Staphylococcus aureus was 19.5 μg/mL. [ABSTRACT FROM AUTHOR]

Summary: Our study aimed at constructing and validating the Lebanese Osteoporosis Knowledge Scale adapted for use among Lebanese women and to assess factors associated with the poorest knowledge of osteoporosis definition, risk factors, and preventive measures. This scale showed adequate psychometric properties; higher knowledge scores were reached in women who already heard about the disease and had a formal education. As a result, the LOKS-19 can be used to measure knowledge of osteoporosis and help assess osteoporosis-related interventions. Introduction: The primary objective of this study was to describe the construction of the Lebanese Osteoporosis Knowledge Scale (LOKS) and assess its psychometric properties in a representative sample of Lebanese women aged 40 years and above. Secondary objectives were to explore factors associated with this knowledge score. Methods: A cross-sectional study carried out between March and June 2018, enrolled 560 women over the age of 40 years living in the community. This proportionate sample was randomly selected from all Lebanese governorates to cover the entire Lebanese area. A survey was developed and adapted to the Lebanese population based on preexisting scales. Personal interviews were conducted to collect data. Results: The items of the LOKS were distributed across seven factors with an Eigenvalue over 1 solution, outlining an overall value of 55.89% of the variance. A high Cronbach's alpha was found for the full scale (0.725). Individuals having a university level of education (beta = 1.62; compared to illiteracy), having heard of osteoporosis (beta = 2.62), taking supplements of calcium and vitamin D compared to none (beta = 0.77), and having had Crohn's disease (beta = 1.71) had significantly higher knowledge scores of osteoporosis; oppositely, having diabetes (beta = − 1.17), currently taking chemotherapy (beta = − 2.25), and ever having had a fracture (beta = − 0.74) were significantly correlated with lower awareness of osteoporosis. Conclusions: Our findings suggest that the LOKS-19 can be used to measure knowledge of osteoporosis and help assess osteoporosis-related interventions. A better knowledge seems to be associated with more preventive measures and less risk of fracture. [ABSTRACT FROM AUTHOR]

Background: It is hypothesised that patients with muscle tension dysphonia have a high prevalence of dysphagia in comparison to normative values reported in the literature. Methods: This prospective study included 44 subjects diagnosed with muscle tension dysphonia, based on symptoms and laryngoscopic findings, and 25 control subjects with no history of dysphonia and normal laryngeal examination findings. Demographic data included age, gender and smoking history. The aetiology of muscle tension dysphonia was classified as primary or secondary. Evaluation involved the Eating Assessment Tool ('EAT-10') questionnaire. Results: Patients' mean age was 45.93 ± 14.95 years, with a female to male ratio of 1.2:1. Fourteen patients had primary muscle tension dysphonia, while 30 had secondary muscle tension dysphonia. Among patients with secondary muscle tension dysphonia, Reinke's oedema was the most common aetiology. There was a significant difference in the prevalence of dysphagia between the study group and the control group (40.9 per cent vs 8 per cent respectively, p < 0.05). Conclusion: This study demonstrates a higher prevalence of dysphagia in patients with the presenting symptom of dysphonia and diagnosed with muscle tension dysphonia in comparison to subjects with no dysphonia. [ABSTRACT FROM AUTHOR]

Water erosion is a degradation form that results in the stripping of mineral and organic elements from the soil. Due to the impact of meteoric factors (rain, wind) this global phenomenon, soil erosion, affects the productivity of agricultural land. Water erosion is a global phenomenon that affects the productivity of agricultural land. The absence of a protective cover and intense precipitation made the Litani River Basin a vulnerable region to water erosion. Besides, the absence of climate data has brought about erosion hazard mapping using a qualitative method which combines factors such as tillage erosion, infiltration into the rocks, land tenure using GIS, and intensity of the precipitation. The results show that a high hazard extends over 39.3% of the study area. Field validation and reliability are estimated at 80% based on soil stripping, the size of landslides and the depth of the receding roots. The model used appears to be applicable to other similar regions in the Mediterranean. [ABSTRACT FROM AUTHOR]

Summary: Our study investigated the characteristics of Lebanese women population groups with the poorest knowledge of osteoporosis definition, risk factors, and preventive measures in order to identify categories that should be targeted in future campaigns and educational programs. Higher knowledge scores were reached in women who already heard about the disease and had a formal education. As a result, osteoporosis awareness campaigns and educational programs are mostly needed in populations with lower educational levels. Introduction: Our study investigated the characteristics of Lebanese women population groups with the poorest knowledge of osteoporosis definition, risk factors, and preventive measures. Methods: A cross-sectional study, conducted between March and June 2018, enrolled 560 community dwelling women aged 40 years and above. A questionnaire was used to collect data. A proportionate random sample from all Lebanese Mohafazat was used. Data collection was performed through personal interviews. The median was used as a cutoff point for both the Knowledge and Health Belief scales. Results: The study results showed that 47.3% of participants had a poor knowledge score. Women who received no education, compared to a higher education and have not previously heard about the disease, had lower knowledge scores. In addition, women not taking calcium and vitamin D supplements and not exercising or exercising less than 20 min per day compared to those having these characteristics had lower osteoporosis knowledge levels. A lower knowledge score was associated with less recognized benefits of adequate calcium intake and regular physical activity, more perceived barriers towards their practice, and a less important health motivation. A lower level of education correlated to the same results. Conclusion: Lower knowledge scores were reached in women who have never heard of osteoporosis and had a lower level of education. As a result, osteoporosis awareness campaigns and educational programs need to target population categories with lower educational levels. [ABSTRACT FROM AUTHOR]

The purpose of this study was to analyse the relationships between age, morphological characteristics (weight, height, body mass index (BMI), fat and lean mass), daily calcium intake (DCI), physical activity and bone mineral apparent density (BMAD) of the whole body (WB), lumbar spine (L2-L4), femoral neck (FN) and 1/3 radius in a group of Lebanese adolescent boys. This study included 60 Lebanese adolescent (16.8 ± 2.1 years old) boys. Body composition and bone mineral density (BMD) were assessed by dual-energy X-ray absorptiometry (DXA). BMAD values of the WB, L2-L4, FN and 1/3 radius were calculated. Physical activity and DCI were assessed using questionnaires. Age was positively related to WB, L2-L4 and 1/3 radius BMD and BMAD. Weight, lean mass and BMI were positively related to WB, L2-L4, FN and 1/3 radius BMD. Moreover, weight, lean mass and BMI were positively associated with L2-L4 and FN BMAD but not with BMAD of the WB and the 1/3 radius, while fat mass percentage was negatively associated with WB BMAD. In conclusion, this study shows that weight, lean mass and BMI are positively associated with BMAD of the weight-bearing bones (L2-L4 and FN) but not with BMAD of the WB and the 1/3 radius in adolescent boys. [ABSTRACT FROM AUTHOR]

Abstract: The aim of this study was to compare bone mineral content (BMC) and areal bone mineral density (aBMD) in overweight and control adolescent boys. This study included 27 overweight (body mass index [BMI]>25kg/m2) adolescent (17.1±2.1yr old) boys and 29 maturation-matched (16.7±2.0yr old) controls (BMI<25kg/m2). Bone mineral area (BMA), BMC, and aBMD were assessed by dual-energy X-ray absorptiometry (DXA) at the whole body (WB), lumbar spine (L2–L4), total hip (TH), femoral neck (FN), and left forearm (ultra distal [UD], mid Radius, 1/3 Radius, and total Radius). Body composition (lean mass, fat mass, and fat mass percentage) was assessed also by DXA. The expressions WB BMC/height, WB aBMD/height, and WB BMAD were used to adjust for WB bone size. WB BMC, WB BMC/height, WB BMA, L2–L4 aBMD, TH aBMD, FN aBMD, and UD aBMD were higher in overweight boys compared with controls (p <0.05). However, WB BMAD was lower in overweight boys compared with controls (p <0.05). After adjustment for weight, lean mass, or BMI, using a one-way analysis of covariance, there were no differences between the 2 groups (overweight and controls) regarding bone characteristics (BMC, BMA, aBMD, BMC/height, aBMD/height, and BMAD of the WB and aBMD of the lumbar spine; the TH; the FN; and the forearm). In conclusion, this study shows that after adjusting for weight, lean mass, or BMI, there are no differences between overweight and control adolescent boys regarding aBMD values. [Copyright &y& Elsevier]

Copyright of Avian Diseases is the property of American Association of Avian Pathologists, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Since 2000, several incursions of bluetongue virus ( BTV) occurred in the Mediterranean Basin involving European and surrounding Countries. The Middle East represents one of the most important gateways for the access of BTV in Europe. Limited data on the BTV situation in this area are available. In this perspective, an epidemiological survey on the presence of BTV in Lebanon was conducted. Of the 181 serum samples tested, 97 (mean = 53.6%; 95% CI: 46.3-60.7) resulted positive when tested for the presence of BTV antibodies by c- ELISA, of these 42 (mean = 42%; 95% CI: 32.8-51.8) serum samples were from sheep and 55 (mean = 67.9%; 95% CI: 57.1-77.1) serum samples were from goats. Fourteen blood samples (14/110; mean = 12.7%; 95% CI: 7.8-20.3), 6 (6/66; mean = 9.1%; 95% CI: 4.4-18.5) from sheep and 8 (8/44; mean = 18.2%; 95% CI: 9.6-32.0) from goats, were positive by qRT- PCR. The results with serum-neutralization assay and typing performed by RT- PCR confirmed that six BTV serotypes are currently circulating in Lebanon, and these serotypes are as follows: 1, 4, 6, 8, 16 and 24. This study is the first report that confirms the presence and circulation of BTV in Lebanon. [ABSTRACT FROM AUTHOR]

Abstract: The aim of this study was to determine the relative importance of lean mass and fat mass on bone mineral density (BMD) in a group of Lebanese postmenopausal women. One hundred ten Lebanese postmenopausal women (aged 65–84yr) participated in this study. Age and years since menopause were recorded. Body weight and height were measured and body mass index (BMI) was calculated. Body composition (lean mass, fat mass, and fat mass percentage) was assessed by dual-energy X-ray absorptiometry (DXA). Bone mineral content (BMC) of the whole body (WB) and BMD of the WB, the lumbar spine (L1–L4), the total hip (TH), the femoral neck (FN), the ultra distal (UD) Radius, and the 1/3 Radius were measured by DXA. The expressions WB BMC/height and WB BMD/height were also used. Weight, BMI, fat mass, and lean mass were positively correlated to WB BMC, WB BMC/height, WB BMD/height, and to WB, L1–L4, TH, FN, UD Radius, and 1/3 Radius BMD. However, using multiple linear regression analyses, fat mass was more strongly correlated to BMC and to BMD values than lean mass after controlling for years since menopause. This study suggests that fat mass is a stronger determinant of BMC and BMD than lean mass in Lebanese postmenopausal women. [Copyright &y& Elsevier]

Background: The aim of the present study was to investigate recent overweight and obesity prevalence rates for Lebanese adolescents, and to examine differences in physical activity, screen time (sum of time spent in front of TV, computer, and videogames), and health-related quality of life (HRQOL) for the first time among normal, overweight, and obese adolescents. Methods: One thousand Lebanese adolescents (14–18 years old) from nine schools participated in the study. Height, weight, physical activity, screen time, and HRQOL variables were assessed using validated self-report questionnaires. Results: A total of 7.8% of boys and 1.75% of girls were obese, and 22.5% of boys and 12.47% of girls were overweight. Normal-weight boys reported higher physical activity scores at health clubs than obese boys. Normal-weight girls reported higher leisure time and total physical activity scores than obese girls. In the normal-weight group, boys reported higher total screen time than girls. Normal-weight boys reported higher physical functioning scores than their obese peers. Normal-weight girls reported higher physical functioning and average HRQOL scores than obese girls. Normal-weight and overweight boys reported higher average HRQOL scores than girls. Conclusion: The present study is the first to provide data on physical activity, screen time, and HRQOL among Lebanese adolescents. Despite the need for further research, all those concerned with the pediatric population are urged to develop and implement effective strategies to increase physical activity and improve HRQOL among adolescents based on the present findings. [ABSTRACT FROM AUTHOR]

CMV infection prevalence in kidney transplant recipients (KTR) is reported to be high in the literature, reaching rates of over 80%. The primary endpoints were the evaluation of the prevalence, the risks factors, and the effects of CMV infection on graft function and survival, as well as patient survival at three years after kidney transplantation. We retrospectively reviewed the medical records of 288 kidney transplant patients operated in three Lebanese transplant centers between 1998 and 2017 with three years of follow-up. The patients were divided into two groups: those free of any CMV infection (271 patients (94%); Group I) and those who suffered from CMV infection (17 patients (6%); Group II). Baseline demographics of the two groups were similar, including recipient and donor gender and age, cause of renal disease, recipient body mass index, pre-transplant fasting blood sugar and dialysis duration, HLA matching between donor and recipient, degree of sensitization in the recipient, type of CMV prophylaxis, maintenance immunosuppression and immunological characteristics. The prevalence of CMV infection is 5.9% among KTR. There were significant differences between the two groups concerning the type of induction therapy and the duration of anti-CMV prophylaxis. The rate of infected patients and infectious episodes were significantly higher in Group II. At 3-years, graft function and survival, patient survival, and the rate of new-onset diabetes were similar between the two groups. The present study is the first to explore the incidence and risk factors of CMV in kidney transplant patients in Lebanon. Comprehensive nationwide studies are therefore necessary to determine the epidemiology and risk factors of CMV infection after kidney transplantation in Lebanon. • Sample of 288 kidney transplant recipients (KTR) was assessed for CMV disease prevalence and risk factors. • Prevalence of CMV disease in KTR was low (5.9%), compared to other studies. • Type of induction therapy and duration of anti-CMV prophylaxis were significant risk factors for CMV disease. • Age and gender of donor and recipient, HLA matching, degree of sensitization did not have significant effects on CMV disease. • Seronegative recipients receiving kidneys from seropositive patients were at highest risk of disease. • This is the first study in Lebanon to assess CMV epidemiology among KTR. [ABSTRACT FROM AUTHOR]

The Cannabis sativa L. ssp. indica (Lam.) plant has been historically utilized as a natural herbal remedy for the treatment of several ailments. In Lebanon, cannabis extracts have long been traditionally used to treat arthritis, diabetes, and cancer. The current study aims to investigate the anti-cancer properties of Lebanese cannabis oil extract (COE) on acute myeloid leukemia using WEHI-3 cells, and a WEHI-3-induced leukemia mouse model. WEHI-3 cells were treated with increasing concentrations of COE to determine the IC 50 after 24, 48 and 72-h post treatment. Flow cytometry was utilized to identify the mode of cell death. Western blot assay was performed to assess apoptotic marker proteins. In vivo model was established by inoculating WEHI-3 cells in BALB/c mice, and treatment commencing 10 days post-inoculation and continued for a duration of 3 weeks. COE exhibited significant cytotoxicity with IC 50 of 7.76, 3.82, and 3.34 μg/mL at 24, 48, and 72 h respectively post-treatment. COE treatment caused an induction of apoptosis through an inhibition of the MAPK/ERK pathway and triggering a caspase-dependent apoptosis via the extrinsic and intrinsic modes independent of ROS production. Animals treated with COE exhibited a significantly higher survival rate, reduction in spleen weight as well as white blood cells count. COE exhibited a potent anti-cancer activity against AML cells, both in vitro and in vivo. These findings emphasize the potential application of COE as a chemotherapeutic adjuvant in treatment of acute myeloid leukemia. [Display omitted] • Lebanese cannabis oil demonstrated potent cytotoxicity against WEHI-3 leukemic cells. • Cannabis oil induces apoptosis through partial inhibition of the MAPK/ERK pathway. • Cannabis oil triggers a caspase-dependent apoptosis via the extrinsic and intrinsic pathways. • Cannabis oil treatment significantly increased survival rate, reduced spleen weight and WBC count in WEHI-3-induced leukemia mouse model. [ABSTRACT FROM AUTHOR]

Regions with high productivity of agriculture, such as the Beqaa Plain, Lebanon, often rely on groundwater supplies for irrigation demand. Recent reports have indicated that groundwater consumption in this region has been unsustainable, and quantifying rates of groundwater depletion has remained a challenge. Here, we utilize 15 years of data (June 2002–April 2017) from the Gravity Recovery and Climate Experiment (GRACE) satellite mission to show Total Water Storage (TWS) changes in Lebanon's Beqaa Plain. We then obtain complimentary information on various hydrologic cycle variables, such as soil moisture storage, snow water equivalent, and canopy water storage from the Global Land Data Assimilation System (GLDAS) model, and surface water data from the largest body of water in this region, the Qaraaoun Reservoir, to disentangle the TWS signal and calculate groundwater storage changes. After combining the information from the remaining hydrologic cycle variables, we determine that the majority of the losses in TWS are due to groundwater depletion in the Beqaa Plain. Results show that the rate of groundwater storage change in the West Beqaa is nearly +0.08 cm/year, in the Rashaya District is −0.01 cm/year, and in the Zahle District the level of depletion is roughly −1.10 cm/year. Results are confirmed using Sentinel-1 interferometric synthetic aperture radar (InSAR) data, which provide high-precision measurements of land subsidence changes caused by intense groundwater usage. Furthermore, data from local monitoring wells are utilized to further showcase the significant drop in groundwater level that is occurring through much of the region. For monitoring groundwater storage changes, our recommendation is to combine various data sources, and in areas where groundwater measurements are lacking, we especially recommend the use of data from remote sensing. [ABSTRACT FROM AUTHOR]

Introduction The aim of study is to compare a population of disabled people taken in charge by multidisciplinary team of rehabilitation in a rehabilitation center (RC) in France and Lebanon, looking for factors that may limit accessibility or medical care and the challenges of socio-professional reintegration. Materials and methods Prospective, descriptive and comparative study, made on disabled hospitalized people in 2 RC (Lebanese and French). A grid includes demographics, disabling conditions, characteristics related to hospitalization and problems found at the exit and the socio-professional reintegration. Information is collected on Microsoft Excel 2007 and information processing performed on SPSS Version 18 software. Results Thirty patients, including 18 handicapped in Lebanon (L) and 12 in France (F). 60% female, mean age 70 years [36–92]. Main pathology: AVC 33.3%, 43.3% fractures. Average Length of stay: F 169 days [SD = 272 days] against L: 39 [SD = 20 days]. ( P value = 0.4). Social coverage rate: F 100% [SD = 0]; L 90% [SD = 7%]. ( P value = 0.01). The length of stay was limited by the paying agent for 8.3% in France 9.4%. Hospitalization shortened for budgetary reasons F 8.3%; L 33.3%. The discharge from hospital to home: F 75%; L 94.4%. Home medical care provided by nurses F 58.3%; L 22.2%. Rehabilitative care to continue: physiotherapy F 75%; L 66.7%, occupational and speech therapy F 16.7%; L 7,5%. 50% of patients in France were the main financial resource of the family before the handicap against 11.1%. The majority of patients were retired. 25% had a job full time in France versus 11.1% in Lebanon. Conclusion Disabling conditions are comparable in Lebanon and France, as well as hospital care. The discharge from the hospital is premature in Lebanon for budgetary reasons and socio-professional reintegration is more difficult and almost impossible. [ABSTRACT FROM AUTHOR]

Objective: To assess the knowledge, attitudes, and practices of graduating medical students in Lebanon regarding sexual health, as well as their readiness to learn about it, and to determine the demographic and educational factors that influence our findings. Methods: Cross‐sectional study. A self‐designed questionnaire exploring various components of sexual health was sent to 578 graduating medical students in Lebanon. Knowledge, attitude, and practice scores were computed and analyzed. Results: The overall mean knowledge score was relatively low (2.61, range −13 to 10). A statistically significant difference was found in the mean knowledge score across religion (P = 0.028) and religiosity (P < 0.001) categories. The mean practice score also differed significantly across income groups (P = 0.010). No other significant associations were found between gender, sexuality, environment, primary source of sexual health education, or language and the mean knowledge, attitude, and practice scores. Conclusion: Additional standardized assessment of medical students' competences in sexual health matters through diverse research models is needed. Re‐examination of existing medical curricula and inclusion of more extensive sexual health education is necessary to improve patient care. Synopsis: Our findings suggest that graduating medical students in Lebanon lack the appropriate training and willingness to address or partake in sexual health matters in clinical practice. [ABSTRACT FROM AUTHOR]

Spices and herbs are widely used in almost all types of food preparation and their microbial contamination may cause spoilage and pose public health risk. Thus, the aim of this study was to assess the effect of packaging, source and a food safety management system (FSMS) on the microbiological quality of spices and dried herbs in a developing country, like Lebanon. For this, a total of 96 composite samples of thirteen most commonly consumed types of spices and dried herbs were collected twice at three-month interval. Each type was purchased in 5 common brands from 4 categories: packaged in companies with FSMS, packaged in companies without FSMS, packaged imported, and unpackaged. Total aerobic mesophilic bacteria (TAMB), sulfite reducing anaerobic bacteria, C. perfringens , coliforms, E. coli , yeasts and molds were found in 89%, 43%, 18%, 15%, 1% and 54% of the samples, respectively. All samples were negative for Salmonella. One per cent, 4%, 6%, 1% and 7% of the samples had unacceptable levels of TAMB, coliforms, sulfite reducing anaerobic bacteria, E. coli , yeasts and molds, respectively. Among the four categories, imported samples had the lowest microbiological load, followed by locally packaged in companies with FSMS, then locally packaged in companies without FSMS and the highest microbiological load was for the unpackaged spices and dried herbs. This study highlighted the importance of storage conditions, good hygienic practices, process controls and FSMSs in the spices and dried herbs sector. • Total counts were found in 89% and yeast and molds in 54% of the samples. • All 96 composite samples were negative for Salmonella. • 6%, and 7% had unacceptable counts of sulfite reducing anaerobes, and yeasts and molds, respectively. • Imported samples had the best microbiological quality, and the poorest one was for the unpackaged products. [ABSTRACT FROM AUTHOR]

Background and Aim: Brucellosis is endemic zoonotic and highly contagious bacterial disease. Recently, several brucellosis cases were reported in Lebanon, causing significant economic losses; however, no study was done so far on farms located in the southern part of the country. Thus, the aim of our study was to estimate the prevalence of Brucella abortus in South Lebanon using three different serological tests in the diagnosis of brucellosis in cattle. Materials and Methods: Seventeen farms from 14 locations in Southern Lebanon were selected. Two hundred and three bovine blood samples of different ages, and 121 milk samples collected from older than 2 years cattle were tested using different serological tests: Rose Bengal test (RBT), milk ring test (MRT), indirect enzyme-linked immunosorbent assay (I-ELISA), and confirmed with competitive ELISA (C-ELISA). Results: Results revealed that approximately 15.3% (confidence interval [CI] 95 10.3-20.2%) and 15.7% (CI 95 9.2-22.2%) of samples were positive using RBT and MRT, respectively. This percentage was significantly higher when using I-ELISA (18.3%) (CI 95 12.9-23.5%) and C-ELISA (18.7%) (CI 95 9.8-27.5%). Among used diagnostic tests, our results showed that ELISA was more accurate for the detection of brucellosis, especially since it detects the late stages of the infection, which is characterized by the presence of immunoglobulin G. The seroprevalence of brucellosis was higher among females. All positive tests were of cattle Holstein breed older than 2 years. Tyre and Jezzine cities had a higher significance in bovine brucellosis than Saida. A positive correlation between human and cattle brucellosis was found. Conclusion: Our results showed that bovine brucellosis is prevalent in southern Lebanon. Lack of research, in addition to little feedback of occurring illness or symptoms, creates a gap in helping to control the spread of the disease. [ABSTRACT FROM AUTHOR]

Background and Aim: Brucellosis is a zoonotic disease caused by the bacterium of the genus Brucella. This disease is present worldwide, especially in developing and underdeveloped countries, where it is endemic. This first-of-its-kind study in Lebanon aimed to assess the prevalence of brucellosis across the country and to determine the efficacy of a vaccine for reducing losses in herds so that its toll on public health is reduced. Materials and Methods: Three hundred and fifty-three blood serum and 261 milk samples were obtained from cows in different areas of Lebanon. The samples were analyzed using serological tests (rose Bengal, milk ring, and indirect enzymelinked immunosorbent assay [ELISA]) and confirmed with competitive ELISA and polymerase chain reaction. Results: The highest rate of Brucellae was found in the Bekaa region (10%). After vaccination of 5 cows and 13 heifers at different times, the results showed that all the vaccinated animals have developed an immune response to brucellosis 60 days after vaccination. This vaccine can be considered as stable and preventative to protect against brucellosis in animals and thus protect the public from this infection. Conclusion: These findings will provide further insight into designing future targeted awareness interventions and adapted policies as efforts toward reducing the prevalence and prevention of brucellosis in cattle in Lebanon. [ABSTRACT FROM AUTHOR]

Objective: To investigate the association between vocal fold Reinke's edema, snoring, and obstructive sleep apnea., Design/methods: Twenty-five patients diagnosed with Reinke's edema and 25 patients with normal laryngeal examination, matched according to age, gender, and body mass index were recruited for this prospective study. Demographic data included age, gender, and body mass index. All patients filled the Berlin Questionnaire, STOP-BANG Sleep Apnea Questionnaire, and the Epworth Sleepiness Questionnaire., Results: Out of 25 patients with Reinke's edema, 36% had Obstructive Sleep Apnea (OSA) as evidenced by having two or more positive categories in the Berlin Questionnaire. In the control group, only 4% had OSA.The difference between the two groups was statistically significant (P value = 0.005). With respect to Epworth Sleepiness Scale and the STOP-BANG Sleep Apnea Questionnaire (P value > 0.05), there was no statistically significant difference between the two groups., Conclusions: This investigation revealed higher prevalence of snoring and obstructive sleep apnea in patients with Reinke's edema as evidenced by the Berlin Questionnaire. The caring physician should be alert to symptoms of airway obstruction for possible early intervention., (Copyright © 2018. Published by Elsevier Inc.)

Objectives: To examine the prevalence of dysphagia in patients presenting with dysphonia and diagnosed with non-neoplastic vocal fold pathology., Methods: A total of 45 patients presenting with dysphonia and diagnosed with non-neoplastic vocal fold pathology and a control group matched according to age and gender were included. Patients with recent history of respiratory tract infection, laryngeal surgery or manipulation, neurologic disorders, head and neck tumors, or history of chemotherapy/radiotherapy were excluded. The primary outcome measure for dysphagia was Eating Assessment Tool-10. Patients with a score above three were considered to have dysphagia., Results: The 45 patients were stratified as 18 males and 27 females, with an overall mean age of 48.23 ± 14.65 years. The most common vocal fold pathology was Reinke edema (28.8%), followed by laryngitis (24.4%), and vocal fold nodules (17.7%) and polyps (13.33%). Out of 45 patients with dysphonia, 37.7% had dysphagia and out of 25 controls, 8% had dysphagia as evidenced by an Eating Assessment Tool-10 score of above three. This prevalence is higher than normative values reported in the literature (16%-22%)., Conclusions: The high prevalence of dysphagia in patients with non-neoplastic vocal fold pathology alludes to the pathogenic role of laryngeal behavior in the development of obstructive swallowing symptoms. The potential benefit of voice and swallowing therapy in the treatment of these patients should be considered., (Copyright © 2018 The Voice Foundation. Published by Elsevier Inc. All rights reserved.)