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A case-control study on lung cancer and radon exposure in dwellings has been carried out in Lazio, a high indoor radon region of Central Italy. A total of about 400 cases and 400 controls were recruited and radon concentration was measured in a total of about 1850 dwellings. In each dwelling, radon concentration measurement devices were placed in both the main bedroom and living room for two consecutive six-month periods. Each radon device, enclosed in a sealed polyethylene bag, contains two LR 115 detectors, each being covered by a thin absorber to reduce the alpha-energy within the detector sensitive range. A quality assurance program, described in this paper, was applied in order to reduce radon concentration measurement uncertainty, which have a significant impact on the results of an epidemiological study. The reported internal quality control and intercomparison results are compared with the results of other studies, and show that the radon measurement precision and accuracy obtained in this study can be considered quite good. [Copyright &y& Elsevier]