1. A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population: the Lipid Treatment Assessment Project 2.
- Author
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Santos RD, Waters DD, Tarasenko L, Messig M, Jukema JW, Chiang CW, Ferrieres J, and Foody JM
- Subjects
- Adult, Aged, Canada, Europe, Female, Humans, Latin America, Male, Middle Aged, Risk Factors, Treatment Outcome, Triglycerides blood, United States, Cholesterol, HDL blood, Cholesterol, LDL blood, Coronary Disease drug therapy, Dyslipidemias drug therapy, Hypolipidemic Agents therapeutic use
- Abstract
Objective: This study evaluated the success in attaining non-HDL-cholesterol (non-HDL-C) goals in the multinational L-TAP 2 study., Methods: 9955 patients ≥20 years of age with dyslipidemia on stable lipid-lowering therapy were enrolled from nine countries., Results: Success rates for non-HDL-C goals were 86% in low, 70% in moderate, and 52% in high-risk patients (63% overall). In patients with triglycerides of >200 mg/dL success rates for non-HDL-C goals were 35% vs. 69% in those with ≤200 mg/dL (p < 0.0001). Among patients attaining their LDL-C goal, 18% did not attain their non-HDL-C goal. In those with coronary disease and at least two risk factors, only 34% and 30% attained respectively their non-HDL-C and LDL-C goals. Rates of failure in attaining both LDL-C and non-HDL-C goals were highest in Latin America., Conclusions: Non-HDL-C goal attainment lagged behind LDL-C goal attainment; this gap was greatest in higher-risk patients., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2012
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