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The aim of this review is to assess how existing literature conceptualizes LGBTQ+ Latinx youth's mental health. Studies were included if they met the following criteria: (a) assessed populations who identified as LGBTQ+ in addition to a racial/ethnic minority identity from Latin America; (b) mean sample age was between 12 and 18; (c) assessed mental health as a dependent variable; (d) reported either quantitative, qualitative, or mixed-method results; (e) written in English; and (f) collected data from participants in the USA. Twenty-three studies were included for review. A thematic synthesis produced four themes: context/setting, persecution, sense of self, and support. [ABSTRACT FROM AUTHOR]