1. Childhood systemic lupus erythematosus in Latin America. The GLADEL experience in 230 children.
- Author
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Ramírez Gómez LA, Uribe Uribe O, Osio Uribe O, Grisales Romero H, Cardiel MH, Wojdyla D, Pons-Estel BA, Catoggio LJ, Soriano ER, Imamura PM, Manni JA, Grimaudo S, Sarano J, Maldonado-Cocco JA, Arriola MS, Gómez G, García MA, Marcos AI, Marcos JC, Scherbarth HR, Marino PC, Motta EL, Drenkard C, Gamron S, Buliubasich S, Onetti CM, Caeiro F, Alvarellos A, Saurit V, Gentiletti S, Quagliatto N, Gentiletti AA, Machado D, Abdala M, Palatnik S, Berbotto GA, Battagliotti CA, Sato E, Sella EM, Souza AS, Costallat LT, Bertolo MB, Coimbra IB, Borba Neto EF, Bonfá E, Tavares JC, Brenol, Xavier R, Mucenic T, Cavalcanti Fde S, Duarte AL, Marques CD, Da Silva NA, de O e Silva AC, Pacheco TF, Molina-Restrepo JF, Molina-López J, Iglesias-Gamarra A, Iglesias-Rodríguez A, Egea-Bermejo E, Guzmán-Moreno RA, Restrepo-Suárez JF, Guibert-Toledano M, Reyes-Llerena GA, Massardo L, Gareca N, Jacobelli S, Neira OJ, Guzmán LR, Garcia-Kutzbach A, Castellanos C, Cajas E, Pascual-Ramos V, Barile-Fabris LA, Miranda-Limón JM, Amigo MC, Silveira LH, De La Torre IG, Orozco-Barocio G, Estrada-Contreras ML, del Pozo MJ, Aranda Baca LE, Quezada AU, Huerta-Yáñez GF, Acevedo-Vásquez EM, Alfaro-Lozano JL, Cucho-Venegas JM, Segami MI, Chung CP, Alva-Linares M, Abadi I, Chacón-Díaz R, Al Snih Al Snih S, Esteva-Spinetti MH, and Vivas J
- Subjects
- Adolescent, Adult, Age of Onset, Child, Female, Humans, Latin America epidemiology, Male, Lupus Erythematosus, Systemic epidemiology, Lupus Erythematosus, Systemic physiopathology
- Abstract
To evaluate disease characteristics of childhood onset SLE in Latin America and to compare this information with an adult population in the same cohort of GLADEL. A protocol was designed as a multicenter, multinational, inception cohort of lupus patients to evaluate demographic, clinical, laboratory and serological variables, as well as classification criteria, disease activity, organ damage and mortality. Descriptive statistics, chi square, Fisher's exact test, Student's t test and multiple logistic regression were used to compare childhood and adult onset SLE. 230 patients were <18 years and 884 were adult SLE patients. Malar rash, fever, oral ulcers, thrombocytopenia and hemolytic anemia and some neurologic manifestations were more prevalent in children (p<0.05). On the other hand, myalgias, Sjögren's syndrome and cranial nerve involvement were more frequently seen in adults (p<0.05). Afro-Latin-American children had a higher prevalence of fever, thrombocytopenia and hemolytic anemia. White and mestizo children had a higher prevalence of malar rash. Mestizo children had a higher prevalence of cerebrovascular disease and cranial nerve involvement. Children met SLE ACR criteria earlier with higher mean values than adults (p: 0.001). They also had higher disease activity scores (p: 0.01), whereas adults had greater disease damage (p: 0.02). In Latin America, childhood onset SLE seems to be a more severe disease than adults. Some differences can be detected among ethnic groups.
- Published
- 2008
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