1. Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital.
- Author
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Fink TT, Marques HHS, Gualano B, Lindoso L, Bain V, Astley C, Martins F, Matheus D, Matsuo OM, Suguita P, Trindade V, Paula CSY, Farhat SCL, Palmeira P, Leal GN, Suzuki L, Odone Filho V, Carneiro-Sampaio M, Duarte AJS, Antonangelo L, Batisttella LR, Polanczyk GV, Pereira RMR, Carvalho CRR, Buchpiguel CA, Xavier ACL, Seelaender M, Silva CA, Pereira MFB, Sallum AME, Brentani AVM, Neto ÁJS, Ihara A, Santos AR, Canton APM, Watanabe A, Santos ACD, Pastorino AC, Franco BDGM, Caruzo B, Ceneviva C, Martins CCMF, Prado D, Abellan DM, Benatti FB, Smaria F, Gonçalves FT, Penteado FD, Castro GSF, Gonçalves GS, Roschel H, Disi IR, Marques IG, Castro IA, Buscatti IM, Faiad JZ, Fiamoncini J, Rodrigues JC, Carneiro JDA, Paz JA, Ferreira JC, Ferreira JCO, Silva KR, Bastos KLM, Kozu K, Cristofani LM, Souza LVB, Campos LMA, Silva Filho LVRF, Sapienza MT, Lima MS, Garanito MP, Santos MFA, Dorna MB, Aikawa NE, Litvinov N, Sakita NK, Gaiolla PVV, Pasqualucci P, Toma RK, Correa-Silva S, Sieczkowska SM, Imamura M, Forsait S, Santos VA, and Zheng Y
- Subjects
- Adolescent, COVID-19 Testing, Child, Humans, Latin America, Male, Prospective Studies, Quality of Life, SARS-CoV-2, Tertiary Care Centers, Post-Acute COVID-19 Syndrome, COVID-19 complications
- Abstract
Objectives: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19)., Methods: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed., Results: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls., Conclusions: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.
- Published
- 2021
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