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OBJECTIVE: This study was conducted to determine PD-L2 expression and its association with grading in patients with mucoepidermoid carcinoma. METHODOLOGY: This descriptive study was conducted over a period of 1 year after taking approval from Institutional Ethical Review board. A total of twenty-four cases of MEC were recruited from different tertiary health care hospitals in Lahore and Multan. Data consisting of demographics and clinical features was collected. Histopathological analysis was done according to Seethala's grading system. Immunohistochemistry (IHC) was performed to observe PD-L2 expression. Data was analyzed by using SPSS 25. RESULTS: The mean age was 30.08 ± 12.8 years and there were 41.7% males and 58.3% females. Most common site of involvement was found to be parotid gland. A total of (54.2%) cases were of low grade. Strong PD-L2 expression was observed in 12(50%) cases while in 5(21%) cases there was week expression. No significant association of PD-L2 expression with grade of tumor was observed. CONCLUSION: Among salivary gland tumors, Mucoepidermoid carcinoma is emerging as most frequently diagnosed malignancy. These tumors originate mainly from parotid glands usually during fourth decade of life. As preliminary data generated from current research has highlighted the expression of PD-L2 in malignant MEC. The expression of PD-L2 was observed in all of the tissue specimens in the current study as detected through IHC irrespective of the grade of the tumor. [ABSTRACT FROM AUTHOR]

Objective: To describe the demographic and histological features of salivary gland pathologies at tertiary care hospital. Study Design: Retrospective Descriptive. Setting: Shalamar Institute of Health Sciences, Lahore. Period: February 2012 to February 2017. Material & Method: 17548 surgical specimens were received during this period. Among these, 50 cases were diagnosed as salivary gland disorders. Statistical analysis was carried out using SPSS version 22. Results: 50 cases were diagnosed as salivary gland disorders out of 17548 surgical resections. Salivary gland disorders were divided into non-neoplastic group (n= 15) and neoplastic group (n = 35), which was further divided into: (i) Benign tumors, (n= 26) and (ii) Malignant tumors, (n= 9). Conclusion: Salivary gland disorders are rare diseases to be encountered clinically. Chronic sialadenitis among non-neoplastic disorders, pleomorphic adenoma among benign tumor and mucoepidermoid carcinoma among malignant tumors were the commonest. [ABSTRACT FROM AUTHOR]