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Background Psoriasis is a common, chronic, inflammatory condition of the skin. The incidence of metabolic syndrome is three times higher in psoriasis which has significant and serious implications on the health of patient overall health and life span. Objective To determine the frequency of metabolic syndrome in patients of chronic plaque psoriasis. Methods It was a Cross sectional study conducted in department of Dermatology, Services Hospital, Lahore on 150 patients were enrolled. All enrolled patients were tested for their fasting blood sugar, fasting lipid levels, postprandial blood sugar, serum cholesterol, and triglycerides levels. Plasma glucose was measured using glucose oxidase method and serum lipids with enzymatic assays. Waist circumference was measured. Blood pressure was recorded. Outcome variable i.e. metabolic syndrome was recorded. Results The mean age of the patients was 49.23±17.59 years, 114 (76%) patients were male and 117 (78%) patients were married. The familial dyslipidemia was detected in 15 (10%) patients and the metabolic syndrome was found in 49 (32.67%) patients. Conclusion This study concluded that in patients of chronic plaque psoriasis approximately one third of the patients are with metabolic syndrome. [ABSTRACT FROM AUTHOR]

Background: Vitamin B12, homocysteine and glutathione peroxidase are the key components of one carbon metabolism, essential for healthy pregnancy. Inconsistency exists as to whether imbalance of these components can contribute to gestational diabetes mellitus (GDM). The current study intended to determine the levels of vitamin B12, homocysteine and glutathione peroxidase in women with gestational diabetes mellitus. Materials and Methods: This cross-sectional study was conducted at the Department of Physiology, University of Health Sciences, Lahore, from 1st January 2019 to 31st December 2020. The study involved 90 pregnant women, who were divided into two groups: pregnant women with GDM (n=45) and pregnant women without GDM (n=45). Serum glutathione peroxidase (GPX), homocysteine (Hcy), vitamin B12 (Vit B12), and fasting blood glucose (FBG) levels were measured in both groups at 28-32 weeks of gestation using ELISA and glucose oxidase method, respectively. Data analysis was done by using SPSS version 23. p<0.05 was set statistically significant. Results: We recorded statistically significant differences between the two groups (GDM vs healthy group) regarding Vit B12 (149.00 pg/mL vs 357.00 pg/mL), Hcy (16.95 µmol/L vs 10.05 µmol/L) and GPX levels (3.15 U/ml vs 5.09 U/ml). Conclusions: Vitamin B12 insufficiency is associated with elevated homocysteine and lower glutathione peroxidase levels in GDM. This is the first study that reports the interaction of one carbon metabolism and antioxidants in GDM in a local population from Pakistan. [ABSTRACT FROM AUTHOR]

Objectives: To determine the levels of vitamin B12 in pregnant women and to explore the relationship of vitamin B12 with maternal BMI and gestational diabetes mellitus. Methods: This cross-sectional study was conducted at Department of Physiology, UHS, Lahore from February 2019 to March 2020. Ninety pregnant women in early third trimester of pregnancy were selected. Fortyfive women had gestational diabetes and forty-five were healthy pregnant women. Serum vitamin B12 and fasting blood glucose (FBG) levels were determined by ELISA and glucose oxidase method respectively. 1st trimester BMI was also recorded. SPSS version 23 was used to analyze the data. Results: Serum vitamin B12 was significantly lower in GDM group (149.41±13.66) as compared to non-GDM group (357.49±42.07). BMI was significantly higher in GDM group (32.94±2.10) as compared to non-GDM group (23.52±1.83). Significant negative correlation (-0.78**) was observed between 1st trimester BMI and vitamin B12 in late pregnancy. Regression analysis revealed that high BMI was associated with decrease in vitamin B12 and increased risk of gestational diabetes mellitus (3.26***). Moreover, vitamin B12 was partially mediating the relationship between BMI and FBG. Conclusion: Low vitamin B12 levels have an association with maternal BMI and gestational diabetes mellitus. [ABSTRACT FROM AUTHOR]