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We investigated the antiasthmatic effect of mogroside V (Mog V) in mice with ovalbumin (OVA)‐induced asthma. Administration of Mog V effectively attenuated OVA‐induced airway hyperresponsiveness and reduced the number of inflammatory cells in bronchoalveolar lavage fluid (BALF). Histological examination showed that Mog V reduced the inflammatory infiltration of the lungs in the asthmatic mice. ELISAs suggested that Mog V effectively decreased the levels of IL‐4, IL‐5, and IL‐13 in BALF and serum levels of OVA‐specific IgE and IgG1 in the asthmatic mice. A quantitative reverse‐transcription PCR assay also indicated that Mog V decreased the mRNA levels of IL‐17A, IL‐23, and RORγt in the lungs of the asthmatic mice (the opposite effect on Foxp3 mRNA). Furthermore, Mog V significantly reduced the OVA‐induced activation of NF‐κB in the lungs. This study indicates that Mog V alleviates OVA‐induced inflammation in airways, and this effect is associated with a reduction in NF‐κB activation. Practical applications: A traditional Chinese medicine herb has been reported to have a strong curative effect on asthma in clinical practice. Siraitia grosvenorii is known in China as a functional food product with the ability to improve lung function. Mogroside V is a triterpene glycoside isolated from S. grosvenorii. Nonetheless, the antiasthmatic effect of mogroside V has not been evaluated yet. The aim of this study was to investigate the antiasthmatic activity of mogroside V in mice with chemically induced asthma. The data from this study will provide some scientific evidence supporting wider use of S. grosvenorii in functional foods. [ABSTRACT FROM AUTHOR]