1. Anti-inflammatory and anti-asthmatic effects of Viola mandshurica W. Becker (VM) ethanolic (EtOH) extract on airway inflammation in a mouse model of allergic asthma.
- Author
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Lee MY, Yuk JE, Kwon OK, Kim HS, Oh SR, Lee HK, and Ahn KS
- Subjects
- Animals, Asthma immunology, Asthma physiopathology, Bronchi pathology, Bronchial Hyperreactivity immunology, Bronchoalveolar Lavage Fluid chemistry, Eosinophilia immunology, Ethanol chemistry, Female, Hypersensitivity, Delayed blood, Hypersensitivity, Delayed chemically induced, Immunoglobulin E analysis, Immunoglobulin E blood, Inflammation drug therapy, Inflammation immunology, Interleukins analysis, Interleukins blood, Korea, Mice, Mice, Inbred BALB C, Mucus drug effects, Ovalbumin immunology, Ovalbumin toxicity, Phytotherapy, Plants, Medicinal, Random Allocation, Anti-Asthmatic Agents therapeutic use, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Asthma drug therapy, Bronchi drug effects, Hypersensitivity, Delayed drug therapy, Plant Extracts therapeutic use, Viola chemistry
- Abstract
Aim of the Study: We investigated the efficacy of Viola mandshurica W. Becker (VM) ethanolic (EtOH) extract in the treatment of bronchial asthma in an ovalbumin (OVA)-induced asthmatic BALB/c mouse model., Materials and Methods: Female BALB/c mice were sensitized with intraperitoneal (i.p.) ovalbumin (OVA) on days 0 and 14, and were next given intranasal OVA on days 28-30. Randomized treatment groups of sensitized mice received VM EtOH extract, dexamethasone, or placebo, orally, from days 28 to 30., Results: VM EtOH extract significantly inhibited increases in total immunoglobulin E (IgE) and cytokines IL-4 and IL-13 levels in serum and bronchoalveolar lavage fluid (BALF), and also effectively suppressed airway hyperresponsiveness (AHR), eosinophilia, and mucus hypersecretion, in mice with OVA-induced asthma., Conclusions: The results suggest that VM EtOH extract and allied extracts could be useful herbal medicines for asthma treatment, and that VM may also be a valuable lead material for anti-asthma drug development., (Copyright 2009 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2010
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