1. Cytotoxic steroidal saponins from the rhizomes of Asparagus oligoclonos.
- Author
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Kim GS, Kim HT, Seong JD, Oh SR, Lee CO, Bang JK, Seong NS, and Song KS
- Subjects
- Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacology, Humans, Inhibitory Concentration 50, Korea, Rhizome chemistry, Saponins chemistry, Saponins pharmacology, Spirostans chemistry, Spirostans pharmacology, Stereoisomerism, Tumor Cells, Cultured, Antineoplastic Agents, Phytogenic isolation & purification, Asparagus Plant chemistry, Plants, Medicinal chemistry, Saponins isolation & purification, Spirostans isolation & purification
- Abstract
Two new steroidal saponins, aspaoligonins A (2) and B (3), were isolated from the methanolic extract of the rhizomes of Asparagus oligoclonos together with a known spirostanol saponin, asparanin A (1). Aspaoligonins A and B were characterized as (25S*)-5beta-spirostan-3beta,17alpha-diol 3-O-beta-D-glucopyranosyl (1-->2)-beta-D-glucopyranoside and (25S*)-5beta-spirostan-3beta,17alpha-diol 3-O-alpha-L-rhamnopyanosyl (1-->4)-[beta-D-xylopyranosyl-(1-->2)]-beta-D-glucopyranoside, respectively, by spectrometric analyses including HRFABMS and 2D NMR. Compounds 1-3 were cytotoxic against five human tumor cell lines with IC50 values of 2.05-2.84 microg/mL.
- Published
- 2005
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