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Introduction: The incidence of Acute Coronary Syndrome (ACS) in the young population has begun to rise. There is not enough data regarding the characteristics of young patients with ACS. Aim: To evaluate risk factors, clinical and angiographic profile of young patients with ACS. Materials and Methods: A prospective observational study was conducted from December 2017 to December 2020 at SSWH, Burdwan Medical College and Hospital, Burdwan, West Bengal, Kolkata, India among 100 patients. Patients with ACS and aged =45 years were enrolled in the study. Patients were divided into two groups: patients with and without obstructive Coronary Artery Disease (CAD). Clinical parameters and coronary angiography data were collected and analysed. The p-value <0.05 was considered significant. Results: The mean age of the study participants was 37.42±5.18 years, and 82 (82%) participants were male. Smoking was the most common risk factor observed in 71 (71%) of the study population, and the majority of these patients had obstructive CAD. The young population suffered more with a high incidence of ST-segment Elevation Myocardial Infarction (STEMI), with 37 (56.06%) had Anterior Wall Myocardial Infarction (AWMI). When analysed angiographically, Obstructive CAD was most commonly found 82 (82%); among those with obstructive CAD, Single-vessel diseases were predominant in 47 (47%) individuals. The percentage of stable angina was significantly higher among patients with obstructive CAD (53.6%) compared to non obstructive CAD (11.1%), (p=0.001). Conclusion: Two leading risk factors, smoking, and tobacco, were significantly associated with the onset of young ACS. The prevalence of single-vessel disease was higher in young patients with ACS compared to double and triple-vessel disease. [ABSTRACT FROM AUTHOR]

Aim: The aim of the present study was to assess the deficiency of vitamin B12 in the patients of type 2 diabetes mellitus with peripheral neuropathy and its correlation. Methods: The participants for the present study were recruited from patients with T2DM seen in the South Eastern Railway Central Hospital, Kolkata. The study was conducted for two years. Results: Patients with diabetic neuropathy were older as majority had age between 61-70 years (55.40%) compared to those without neuropathy (majority had age between 51-60 years; 39.80%). The sex distribution between group was significantly different as revealed by the highly significant p value of <0.001. 9.60% of the patients with diabetes neuropathy had vitamin B 12 deficiency compared to control group (1.20%). Diabetes neuropathy patients had mean Vitamin B12 (471.33±168.992), diabetes with no neuropathy patients (479.11±208.121). Subjects in control group had higher Vitamin B12 level compared to remaining two groups. Conclusion: Vitamin B12 deficiency is highly prevalent, especially in patients with diabetic neuropathy. In this study an inverse correlation was found between diabetic neuropathy and the plasma level of vitamin B12. The association between diabetic neuropathy and Vitamin B12 deficiency is of great importance, since diabetic or prediabetic patients diagnosed with diabetic neuropathy may have neuropathy due to vitamin B12 deficiency. [ABSTRACT FROM AUTHOR]