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Epibiotic bacteria associated with the filamentous marine cyanobacterium Moorea producens were explored as a novel source of antibiotics and to establish whether they can produce cyclodepsipeptides on their own. Here, we report the isolation of micrococcin P1 ( 1 ) (C 48 H 49 N 13 O 9 S 6 ; obs. m / z 1144.21930/572.60381) and micrococcin P2 ( 2 ) (C 48 H 47 N 13 O 9 S 6 ; obs. m / z 1142.20446/571.60370) from a strain of Bacillus marisflavi isolated from M. producens ' filaments. Interestingly, most bacteria isolated from M. producens ' filaments were found to be human pathogens. Stalked diatoms on the filaments suggested a possible terrestrial origin of some epibionts. CuSO 4 ·5H 2 O assisted differential genomic DNA isolation and phylogenetic analysis showed that a Kenyan strain of M. producens differed from L. majuscula strain CCAP 1446/4 and L. majuscula clones. Organic extracts of the epibiotic bacteria Pseudoalteromonas carrageenovora and Ochrobactrum anthropi did not produce cyclodepsipeptides. Further characterization of 24 Firmicutes strains from M. producens identified extracts of B. marisflavi as most active. Our results showed that the genetic basis for synthesizing micrococcin P1 ( 1 ), discovered in Bacillus cereus ATCC 14579, is species/strain-dependent and this reinforces the need for molecular identification of M. producens species worldwide and their epibionts. These findings indicate that M. producens -associated bacteria are an overlooked source of antimicrobial compounds.