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A recent study conducted at the University of Louisville in Kentucky explores the role of neutral ceramidase in breast cancer progression. The researchers found that the deletion of neutral ceramidase in breast cancer models in female mice led to accelerated tumor growth. They also discovered that myeloid neutral ceramidase is necessary for the generation of lipid droplets and the induction of lipolysis, which affects macrophage metabolism. The study suggests that neutral ceramidase plays a role in the reprogramming of the tumor microenvironment and the development of immunosuppressive tumor-associated macrophages, which contribute to T cell exhaustion in breast cancer. [Extracted from the article]