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The E-W Kanggur tectonic belt, a major tectonic belt in the Eastern Tianshan (ETS) of the Central Asian Orogenic Belt (CAOB), records the amalgamation history between the ETS and the Tarim Craton. Two generations of structural deformation (D1 and D2) are recognized by field observations in the Jingerquan, Huangshan-Jingxia, Yamansu North Mountain, and Nanbeidagou-Kanggurtag areas. Early deformation is exhibited by vertical 'A' type (asymmetrical and symmetrical) S0 folds, lenticular symmetrical boudins, S-C fabric, and nearly vertical S1 foliation, demonstrating an ~N-S compressional setting. Late deformation is characterized by ~E-W-trending dextral shearing and local S1 folding. Transpressional deformation explains the kinematic compatibility of these fold and shear structures. The new U-Pb zircon and Ar/Ar age data in this study provide constraints on the timing of deformation, suggesting that D1 occurred in the late Carboniferous-early Permian (300–286 Ma) and that dextral shearing (D2) likely occurred in the middle-late Permian (262–233 Ma). The ~N-S contraction was driven by orogenic thickening during the convergence of the North Tianshan (NTS) island arc system, the Central Tianshan (CTS), and the Tarim Craton. Dextral transpression is related to the oblique convergence between the Eastern Tianshan (ETS) and Tarim Craton. On a larger scale, dextral kinematics along the Main Tianshan Shear Zone in the Eastern and Western Tianshan, together with sinistral shearing in northeastern Kazakhstan and the Chinese Altai, accommodated the eastward escape of central orogenic materials, which were possibly affected by the convergence of the Siberian, Baltic, and Tarim Cratons. [ABSTRACT FROM AUTHOR]