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To assess the present methods used for segregation, storage configurations, collection, and disposal systems in Karachi's tertiary hospitals. Using a convenient sample technique, a cross-sectional survey was done in ten tertiary hospitals in Karachi. The research tool was a self-administered questionnaire that included questions about hospital waste management and health waste management information. Hospital healthcare services may produce certain infectious wastes. Even though a large portion of hospital waste is categorized as general waste, which is like municipal solid waste in nature and can therefore be disposed of in municipal landfills, a small portion of infectious waste needs to be managed properly to reduce risk to public health. The many components of the hospital waste management system frequently interact with one another, necessitating a thorough examination to ascertain each component's function. Numerous factors, including the number of beds in the hospitals, have an impact on the development of hospital waste. Waste segregation and infectious waste treatment before disposal must be adequately carried out by the hospital management, particularly when scavenging occurs in dump sites in developing nations. More medical waste management education and training should be promoted in developing countries. More studies on teaching waste management to hospital staff members should be encouraged. [ABSTRACT FROM AUTHOR]