1. Chemical constituents of Osyris alba and their antiparasitic activities.
- Author
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Al-Jaber HI, Mosleh IM, Mallouh A, Abu Salim OM, and Abu Zarga MH
- Subjects
- Animals, Antiparasitic Agents chemistry, Catechin chemistry, Chlorocebus aethiops, Jordan, Metronidazole pharmacology, Molecular Structure, Parasitic Sensitivity Tests, Pyrrolizidine Alkaloids chemistry, Stereoisomerism, Vero Cells, Antiparasitic Agents isolation & purification, Antiparasitic Agents pharmacology, Entamoeba histolytica drug effects, Giardia lamblia drug effects, Pyrrolizidine Alkaloids isolation & purification, Pyrrolizidine Alkaloids pharmacology, Santalaceae chemistry
- Abstract
Phytochemical investigation of Osyris alba L. (Santalaceae) of Jordanian origin resulted in the isolation and identification of one new pyrrolizidine alkaloid, osyrisine (1), together with 16 other known compounds. The structures of all compounds were established on the basis of spectroscopic analysis. Osyrisine, catechin, and catechin-3-O-α-L-rhamnopyranoside exhibited a significant level of antiparasitic activity against two parasites, Entamoeba histolytica and Giardia intestinalis.
- Published
- 2010
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