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Objective: To evaluate the effect of extracorporeal shockwave therapy (ESWT) on chronic pelvic pain syndrome (CPPS)/chronic a bacterial prostatitis after failure of most other modalities of treatment. Materials and Methods: In a follow-up survey, 25 patients with CPPS who failed at least previously 3 modalities of treatment other than ESWT were evaluated at 2 weeks after finishing the course of ESWT. All patients were treated by ESWT once a week for 4 weeks by a protocol of 2500 impulses at one bar over 13 minutes. The investigation was designed as an open-label uncontrolled therapeutic clinical trial which was conducted in Jordan university hospital through the period 2014-2015. The follow-up assessments were carried out by National Institutes of Health- Chronic Prostatitis Symptom Index (NIH-CPSI), International prostate symptom score (IPSS), American Urological Association (AUA) Quality of Life Due to Urinary Symptoms (QOL_US) and International Index of Erectile Function (IIEF). Data were compared using paired samples t-test. Results: Of our total 29 patients 4 of them did not complete the study protocol, 25 patients were evaluated. The mean of NIH-CPSI, IPSS, AUA QOL_US and IIEF were evaluated pre and post ESWT and it showed statistically significant improvement without any significant side-effect of the treatment. Conclusions: Although ESWT seems to be safe and effective specially in intractable cases, long term follow up is still mandatory to determine the effectiveness and long term benefit of ESWT and whether there is a need for further sessions, if the benefit will be the same as compared to the first course and to closely monitor patients of any side effect if present. [ABSTRACT FROM AUTHOR]