1. Clinical characteristics of Japanese oropharyngeal squamous cell carcinoma positive for human papillomavirus infection.
- Author
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Nomura, Fuminori, Sugimoto, Taro, Kitagaki, Keisuke, Ito, Takashi, Kawachi, Hiroshi, Eishi, Yoshinobu, Watanabe, Ken, Igaue, Miki, Shimizu, Norio, Tomita, Makoto, Kitamura, Ken, and Kishimoto, Seiji
- Subjects
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FISHER exact test , *IMMUNOHISTOCHEMISTRY , *MONOCLONAL antibodies , *MOUTH tumors , *PAPILLOMAVIRUS diseases , *SQUAMOUS cell carcinoma , *STATISTICS , *DATA analysis , *PROPORTIONAL hazards models , *DATA analysis software , *DESCRIPTIVE statistics , *KAPLAN-Meier estimator , *SEQUENCE analysis , *LOG-rank test - Abstract
Conclusion: Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) is considered to be a distinct entity in Japan. The combination of both HPV-DNA sequencing analysis and immunohistochemistry (IHC) for p16INK4A is useful to discriminate the OPSCC patients with a better prognosis from other cases, especially in the advanced stage. Surgical treatment is recommended for HPV-negative advanced cancer. Objective: The number of HPV-related OPSCCs has been increasing worldwide. However, the incidence and prognostic significance of this cancer in Japan have not yet been fully elucidated. Methods: Seventy-seven Japanese patients with OPSCC were enrolled in this study. The prevalence of HPV-DNA was assessed by PCR and sequencing. The expression of p16INK4A and p53 was examined by IHC. The clinicopathological parameters and disease-specific survival were analyzed for HPV-positive and -negative patients. Results: HPV-DNA was detected in 32 patients. Thirty-four patients were p16INK4A-positive by IHC. The patients who were positive for HPV infection were significantly younger. Furthermore, in the stage III or IV cases, the 3-year disease-specific survival of the HPV infection-positive group was significantly better than that of the HPV-negative group. Surgical treatment was demonstrated to lead to a good prognosis for the patients with HPV-negative advanced cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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