1. The Effect of Hydroxyapatite-Coated Titanium Fiber Web on Human Osteoblast Functional Activity.
- Author
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Hirota, Makoto, Hayakawa, Tohru, Ametani, Akihiro, Kuboki, Yoshinori, Sato, Mitsunobu, and Tohnai, Iwai
- Subjects
BONE physiology ,TITANIUM ,COLLAGEN ,CARRIER proteins ,RESEARCH funding ,T-test (Statistics) ,EQUIPMENT & supplies ,PHYSIOLOGY ,THERAPEUTICS - Abstract
Purpose: The aim of this study was to evaluate human osteoblast activity on thin hydroxyapatite (HA)-coated three-dimensional scaffolds made of titanium fiber web. Materials and Methods: A thin HA film was coated on a titanium fiber web by the molecular precursor method. Human osteoblasts were disseminated onto the uncoated and HA-coated titanium fiber web, and osteoblast activity was observed at days 3, 7, 14, and 21 of culture. Results: Proliferation activities of osteoblasts were significantly higher in the uncoated titanium fiber web. Osteoblasts in the uncoated titanium fiber web showed a typical expression pattern, but those in the HA-coated titanium fiber web showed rapid osteocalcin expression and calcification at an early stage of culture. Moreover, osteocalcin expression per osteoblast was significantly higher in the HA-coated group. Conclusion: These results suggest that HA coating with the molecular precursor method accelerated osteoblast functional activity. [ABSTRACT FROM AUTHOR]
- Published
- 2011