1. Regenerative medicine using stem cells from human exfoliated deciduous teeth (SHED): a promising new treatment in pediatric surgery.
- Author
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Taguchi T, Yanagi Y, Yoshimaru K, Zhang XY, Matsuura T, Nakayama K, Kobayashi E, Yamaza H, Nonaka K, Ohga S, and Yamaza T
- Subjects
- Animals, Cell- and Tissue-Based Therapy trends, Child, Hepatocytes transplantation, Humans, Japan, Liver, Liver Transplantation, Mice, Printing, Three-Dimensional, Cell- and Tissue-Based Therapy methods, Pediatrics, Regenerative Medicine methods, Stem Cells, Tissue Engineering methods, Tooth Exfoliation, Tooth, Deciduous cytology
- Abstract
Stem cells from human exfoliated deciduous teeth (SHEDs), being a type of mesenchymal stem cell, are an ideal cell source for regenerative medicine. They have minimal risk of oncogenesis, high proliferative capacity, high multipotency, and immunosuppressive ability. Stem cell transplantation using SHED has been found to have an anti-fibrotic effect on liver fibrosis in mice. SHED transplantation and the bio 3D printer, which can create scaffold-free 3-D images of the liver and diaphragm, provide a new innovative treatment modality for intractable pediatric surgical diseases such as biliary atresia and diaphragmatic hernia.
- Published
- 2019
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