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Japan is an area affected strongly by land surface upheaval and by climate change instability. Background evidence of increasing and magnifying geo-disasters includes the following: (i) frequent and extremely severe torrential rainfall; (ii) high and increasing frequency of strong earthquakes (5+ and 6- as the Japan Meteorological Agency seismic intensity scale); and (iii) typhoons with magnified damage effects. Based on a review of that information stated above, an attempt has been made to overview the present situation and future trends of geo-disasters in the context of climate change and to present possible adaptive measures against disasters. Particularly, emphasis is assigned to the importance of the combined effects of plural events, which increases the probability of extreme events, sometimes triggering devastating consequences. Adaptive measures against climate change-associated geo-disasters are presented by classification into software and hardware. Special emphasis is devoted to the availability of information and communication technology (ICT) and information, communication and robot technology (ICRT) involving devices such as IC-sensors and Un-crewed Aerial Vehicles (UAV, drones), which are useful in early warning systems and in simple monitoring systems. [ABSTRACT FROM AUTHOR]

Background: The clinical significance of the Epstein-Barr virus (EBV) status and p16 expression was unknown in nasopharyngeal carcinoma (NPC)., Methods: We retrospectively studied our pathology database for 13 years to determine the prevalence of EBV and p16 expression and their association with prognosis in cases of NPC. We performed immunohistochemistry for the p16 protein and in situ hybridization (ISH) for EBV-encoded small RNAs and human papillomavirus (HPV) DNA., Results: Of the 43 patients with NPC, 27 (63%), 6 (14%), and 10 (23%) cases were EBV positive, EBV negative with keratinization, and EBV negative without keratinization, respectively. No cases were HPV positive by ISH. Among the 21 EBV-positive tumours that were tested for p16, only 2 tumours were p16 positive. The keratinization-positive group included only males, typically >60 years of age (5 of 6) and with T4 tumours (3 of 6). In contrast, the EBV-positive cohort tended to be younger (<60 years, 13 of 27) and have progressive N-stage tumours (N2-3, 14 of 27). The keratinization and EBV-negative cohort included predominantly males (9 of 10) who were likely p16 negative (4 of 10) and smokers (7 of 10). Multivariate analysis confirmed that keratinization was an independent prognostic factor for progression-free survival., Conclusion: In areas, such as Japan, that are nonendemic for both EBV and HPV, the causality of NPC appears to be more heterogeneous., (© 2017 S. Karger AG, Basel.)