1. PPARγ gene polymorphism, C-reactive protein level, BMI and periodontitis in post-menopausal Japanese women.
- Author
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Wang, Yangming, Sugita, Noriko, Yoshihara, Akihiro, Iwasaki, Masanori, Miyazaki, Hideo, Nakamura, Kazutoshi, and Yoshie, Hiromasa
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GENETIC polymorphism research ,POPULATION genetics ,AMPLIFIED fragment length polymorphism ,C-reactive protein ,ACUTE phase proteins ,DISEASE susceptibility ,GENETIC polymorphisms ,PERIODONTAL disease ,PERIODONTICS ,PERIODONTITIS ,PROTEINS ,REGRESSION analysis ,BODY mass index ,POSTMENOPAUSE ,GENOTYPES - Abstract
Background: Several studies have reported inconsistent results regarding the association between the PPARγPro12Ala polymorphism and obesity. Obese individuals had higher C-reactive protein (CRP) levels compared with those of normal weight, and PPARγ activation could significantly reduce serum high-sensitive CRP level. We have previously suggested that the Pro12Ala polymorphism represents a susceptibility factor for periodontitis, which is a known risk factor for increased CRP level.Objectives: The aim was to investigate associations between PPARγ gene polymorphism, serum CRP level, BMI and/or periodontitis among post-menopausal Japanese women.Materials and Methods: The final sample in this study comprised 359 post-menopausal Japanese women. Periodontal parameters, including PD, CAL and BOP, were measured per tooth. PPARγPro12Ala genotype was determined by PCR-RFLP. Hs-CRP value was measured by a latex nephelometry assay.Results: No significant differences in age, BMI or periodontal parameters were found between the genotypes. The percentages of sites with PD ≥ 4 mm were significantly higher among the hsCRP ≥ 1 mg/l group than the hsCRP < 1 mg/l group (p = 0.003). Positive correlations were found between serum hsCRP levels and the percentages of sites with PD ≥ 4 mm (p = 0.043) in PPARγ Ala allele carriers, and BMI (p = 0.033) in non-carriers. After adjustment for model covariates, BMI was significantly associated with serum hsCRP level.Conclusion: The PPARγPro12Ala polymorphism was not independently associated with periodontitis, serum CRP level or BMI in post-menopausal Japanese women. However, serum hsCRP level correlated with periodontitis in Ala allele carriers, and with BMI in non-carriers. [ABSTRACT FROM AUTHOR]- Published
- 2016
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