24 results on '"Ukimura, O."'
Search Results
2. Efficacy of robot-assisted partial nephrectomy compared to conventional laparoscopic partial nephrectomy for completely endophytic renal tumor: a multicenter, prospective study.
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Hinata N, Murakami S, Nakano Y, Hara I, Kondo T, Hamamoto S, Shiroki R, Nagayama J, Kawakita M, Eto M, Ukimura O, Takenaka A, Takagi T, Shimbo M, Azuma H, Yoshida T, Furukawa J, Kawamorita N, and Fujisawa M
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- Humans, Male, Female, Middle Aged, Prospective Studies, Aged, Treatment Outcome, Warm Ischemia, Japan, Carcinoma, Renal Cell surgery, Glomerular Filtration Rate, Margins of Excision, Nephrectomy methods, Kidney Neoplasms surgery, Laparoscopy methods, Robotic Surgical Procedures methods
- Abstract
Background: This study aimed to compare the efficacy of robot-assisted partial nephrectomy for completely endophytic renal tumors with the reported outcomes of conventional laparoscopic partial nephrectomy and investigate the transition of renal function after robot-assisted partial nephrectomy., Methods: We conducted a prospective, multicenter, single-arm, open-label trial across 17 academic centers in Japan. Patients with endophytic renal tumors classified as cT1, cN0, cM0 were included and underwent robot-assisted partial nephrectomy. We defined two primary outcomes to assess functional and oncological aspects of the procedure, which were represented by the warm ischemic time and positive surgical margin, respectively. Comparisons were made using control values previously reported in laparoscopic partial nephrectomy studies. In the historical control group, the warm ischemia time was 25.2, and the positive surgical margin was 13%., Results: Our per-protocol analysis included 98 participants. The mean warm ischemic time was 20.3 min (99% confidence interval 18.3-22.3; p < 0.0001 vs. 25.2). None of the 98 participants had a positive surgical margin (99% confidence interval 0-5.3%; p < 0.0001 vs. 13.0%). The renal function ratio of eGFR before and after protocol treatment multiplied by splits was 0.70 (95% confidence interval: 0.66-0.75). Factors such as preoperative eGFR, resected weight, and warm ischemic time influenced the functional loss of the partially nephrectomized kidney after robot-assisted partial nephrectomy., Conclusions: Robot-assisted partial nephrectomy for completely endophytic renal tumors offers a shorter warm ischemia time and comparable positive surgical margin rate compared with conventional laparoscopic partial nephrectomy., (© 2024. The Author(s).)
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- 2024
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3. Treatment impact of newly approved therapeutic agents for metastatic urothelial carcinoma in Japan: a single-center retrospective study.
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Inoue Y, Yamada T, Fujihara A, Miyashita M, Shiraishi T, Okumi M, Hongo F, and Ukimura O
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- Humans, Retrospective Studies, Japan, Carcinoma, Transitional Cell drug therapy, Urinary Bladder Neoplasms pathology
- Abstract
Although recent clinical trials of new therapeutic agents for metastatic urothelial carcinoma have shown prolonged overall survival, there are few real-world evidence. To assess the impact of new therapeutic agents, we performed retrospective analysis for consecutive 158 metastatic urothelial carcinoma patients who performed systemic therapy in our institution between May 2008 and August 2023. We defined a period from May 2008 to December 2017, when pembrolizumab was first introduced to the clinical setting in the new therapeutic agents for metastatic urothelial carcinoma in Japan, as "pre new drug era" and a period from January 2018 to August 2023 as "post new drug era". We compared overall survival between pre- and post- new drug era using Kaplan-Meier method with log rank test. Median overall survival of pre- and post- new drug era were 14.5 months (95% confidence intervals: 11.6-16.7) and 23.1 months (95% confidence intervals: 14.5-NA), respectively (p < 0.001). Five-year survival rate of pre- and post- new drug era was 7.0% (95% confidence intervals: 2.3-15.3) and 36.3% (95% confidence intervals: 21.4-51.5), respectively. Multivariable Cox proportional hazards regression analysis of factors associated with overall survival showed that enfortumab vedotin administration, administration of second-line or more systemic therapy, best overall response of SD, PR and CR in first-line systemic therapy, higher serum albumin and lower CRP were factors for overall survival prolongation. Introduction of new therapeutic agents for metastatic urothelial carcinoma contributed to the improvement of overall survival in comparison with the era without these agents., (© 2023. Springer Nature Limited.)
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- 2023
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4. A big data-based prediction model for prostate cancer incidence in Japanese men.
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Kato M, Horiguchi G, Ueda T, Fujihara A, Hongo F, Okihara K, Marunaka Y, Teramukai S, and Ukimura O
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- Humans, Male, Incidence, Retrospective Studies, Japan epidemiology, Adolescent, Young Adult, Adult, Middle Aged, Aged, Aged, 80 and over, Reference Values, Risk Assessment, Risk Factors, Biomarkers, Tumor blood, Predictive Value of Tests, Big Data, East Asian People, Prostate-Specific Antigen blood, Prostatic Neoplasms blood, Prostatic Neoplasms epidemiology
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To define a normal range for PSA values (ng/mL) by age and create a prediction model for prostate cancer incidence. We conducted a retrospective analysis using 263,073 observations of PSA values in Japanese men aged 18-98 years (2007-2017), including healthy men and those diagnosed with prostate cancer. Percentiles for 262,639 PSA observations in healthy men aged 18-70 years were calculated and plotted to elucidate the normal fluctuation range for PSA values by age. Univariable and multivariable logistic regression analyses were performed to develop a predictive model for prostate cancer incidence. PSA levels and PSA velocity increased with age in healthy men. However, there was no difference in PSA velocity with age in men diagnosed with prostate cancer. Logistic regression analysis showed an increased risk of prostate cancer for PSA slopes ranging from 0.5 to 3.5 ng/mL/year. This study provides age-specific normal fluctuation ranges for PSA levels in men aged 18-75 years and presents a novel and personalized prediction model for prostate cancer incidence. We found that PSA slope values of > 3.5 ng/mL/year may indicate a rapid increase in PSA levels caused by pathological condition such as inflammation but are unlikely to indicate cancer risk., (© 2023. The Author(s).)
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- 2023
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5. Editorial Comment to Genomic landscape of treatment-naïve urological cancers using next-generation sequencing-based panel test in the Japanese population.
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Shimizu T and Ukimura O
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- Genomics, Humans, Japan, High-Throughput Nucleotide Sequencing, Urologic Neoplasms genetics, Urologic Neoplasms therapy
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- 2022
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6. Impact of prostate-specific antigen screening on tumor size in patients with prostate cancer in a super-aging district in Kyoto, Japan.
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Matsugasumi T, Okihara K, Tsujimoto M, Sato O, Imura T, Yamada Y, Fujihara A, Shiraishi T, Hongo F, and Ukimura O
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- Age Factors, Early Detection of Cancer, GPI-Linked Proteins, Humans, Japan, Magnetic Resonance Imaging, Male, Retrospective Studies, Antigens, Neoplasm, Neoplasm Proteins, Prostate-Specific Antigen, Prostatic Neoplasms diagnosis
- Abstract
Background: Population-based prostate-specific antigen (PSA) screening is effective for reducing prostate cancer (PCa)-related mortality rates. In this study, we assessed biopsy-proven maximum cancer core length (MCCL) and maximum cancer diameter on magnetic resonance imaging (MRI; MCDM) in prostate biopsy and multiparametric MRI (mp-MRI) by PCa detection., Methods: We retrospectively assessed 214 male PCa patients and 187 PCa patients with Prostate Imaging Reporting and Data System version 2 (PI-RADS) category 3-5 lesions in pre-biopsy mp-MRI and targeted biopsy characteristics. The mean biopsy-proven MCCL and MCDM were compared among three PSA screening groups, namely the population-based PSA screening (PBS), opportunistic PSA screening (OPS), and symptomatic outpatient PSA examination (SOP) groups., Results: The median age and PSA value of the 214 participants were 75 years and 7.9 ng/mL, respectively. In the PBS, OPS, and SOP groups, the median ages were 73, 76, and 76 years, respectively (p = 0.046); PSA values were 7.2, 9.5, and 11.5 ng/mL, respectively (p < 0.001); and biopsy-proven MCCL and MCDM were significantly increased to 7, 10, and 14 mm (p < 0.001) and to 11, 15, and 17 mm (p < 0.001), respectively. In the 187 PCa patients with PI-RADS category 3-5 lesions on mp-MRI, MCDM were 11, 14, and 17 mm (p < 0.001), respectively., Conclusions: The biopsy-proven MCCL and MCDM were significantly smaller in the PBS and OPS groups than in the SOP group, which suggests that PSA screening detected PCa earlier than in symptomatic patients. PSA screening with MRI could objectively lead to earlier diagnosis based on tumor size., (© 2021. Japan Society of Clinical Oncology.)
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- 2021
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7. Fertility and reproductive technology use in testicular cancer survivors in Japan: A multi-institutional, cross-sectional study.
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Yamashita S, Kakimoto K, Uemura M, Kishida T, Kawai K, Nakamura T, Goto T, Osawa T, Yamada S, Nishimura K, Nonomura N, Kojo K, Shiraishi T, Ukimura O, Ogawa O, Shinohara N, Suzukamo Y, Ito A, and Arai Y
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- Adult, Cross-Sectional Studies, Fertility, Humans, Japan epidemiology, Male, Reproductive Techniques, Survivors, Testicular Neoplasms drug therapy
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Objective: To evaluate fertility and use of reproductive technology of testicular cancer survivors in a multi-institutional, cross-sectional study., Methods: This study recruited testicular cancer survivors who were followed after treatment for testicular cancer at eight high-volume institutions between 2018 and 2019. The participants completed the questionnaires on marital status, fertility and use of reproductive technology., Results: A total of 567 testicular cancer survivors, with a median age of 43 years, responded to the questionnaire. Chemotherapy was given to 398 survivors, including three cycles of cisplatin-based chemotherapy in 106 patients and four cycles in 147 patients. Among 153 survivors who attempted sperm cryopreservation, 133 (87%) could preserve sperm. Of the 28 survivors whose cryopreserved sperm was used, 17 (61%) fathered children. Of the 72 survivors who fathered children without the use of cryopreserved sperm, 59 (82%) fathered naturally. Whereas 33 (20%) of 169 survivors treated without chemotherapy fathered children without using cryopreserved sperm, 39 (10%) of 398 treated with chemotherapy fathered children (P < 0.05). Furthermore, the paternity rate was 12% and 5% in testicular cancer survivors with three and four cycles of cisplatin-based chemotherapy, respectively (P < 0.05). However, of 121 survivors who wanted to have children, 14 (12%) received counseling about infertility treatment., Conclusions: Testicular cancer survivors preserving their sperm have a higher paternity rate after chemotherapy, especially after four cycles, than those not using cryopreserved sperm. Physicians who give chemotherapy for testicular cancer need to take particular care not only with respect to recurrence of testicular cancer, but also to post-treatment fertility., (© 2021 The Japanese Urological Association.)
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- 2021
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8. Health-Related Quality of Life in Testicular Cancer Survivors in Japan: A Multi-Institutional, Cross-Sectional Study Using the EORTC QLQ-TC26.
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Yamashita S, Kakimoto K, Uemura M, Kishida T, Kawai K, Nakamura T, Goto T, Osawa T, Yamada S, Nishimura K, Nonomura N, Nishiyama H, Shiraishi T, Ukimura O, Ogawa O, Shinohara N, Suzukamo Y, Ito A, and Arai Y
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- Adult, Cross-Sectional Studies, Functional Status, Humans, Japan epidemiology, Male, Psychometrics, Surveys and Questionnaires, Work Performance, Cancer Survivors psychology, Cancer Survivors statistics & numerical data, Neoplasm Recurrence, Local psychology, Patient Care Management methods, Patient Care Management statistics & numerical data, Quality of Life, Testicular Neoplasms epidemiology, Testicular Neoplasms pathology, Testicular Neoplasms psychology, Testicular Neoplasms therapy
- Abstract
Objective: To evaluate the health-related quality of life (QOL) of testicular cancer (TC) survivors using the Japanese version of the EORTC QLQ-TC26 questionnaire in a multi-institutional, cross-sectional study., Methods: This study recruited TC survivors who were followed after treatment for TC at eight high-volume institutions between January, 2018 and March, 2019. The participants completed the EORTC QLQ-TC26 questionnaire and mailed the completed questionnaires to a central institution. The QOL scores were assessed according to therapeutic modality (watchful waiting, WW; chemotherapy, CT; and CT followed by retroperitoneal lymph node dissection, CT+RPLND) and follow-up period and compared using analysis of variance and Student's t-test., Results: A total of 567 TC survivors responded to the questionnaire. The median age at response was 43 years (IQR 35-51 years), and the median follow-up was 5.2 years (IQR 2.2-10.0 years). As for treatment side effects and physical limitations, the scores of the CT+RPLND group were significantly higher than those of the WW group, especially within one year after treatment. In addition, TC survivors in the CT+RPLND group reported high impairment related to job and education problems and future perspective less than 5 years after treatment. Even TC survivors in the WW group were anxious about job and education issues within one year after treatment., Conclusion: TC survivors were anxious about not only cancer recurrence, but also their jobs and education. TC patients should be given appropriate information on QOL after treatment for TC to attenuate post-treatment anxiety and improve their health-related QOL., (Copyright © 2021 Elsevier Inc. All rights reserved.)
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- 2021
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9. Validation study of the Japanese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Testicular Cancer 26 for patients with testicular cancer.
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Yamashita S, Suzukamo Y, Kakimoto K, Uemura M, Kishida T, Kawai K, Nakamura T, Goto T, Osawa T, Yamada S, Nishimura K, Nonomura N, Nishiyama H, Shiraishi T, Ukimura O, Ogawa O, Shinohara N, Ito A, and Arai Y
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- Child, Child, Preschool, Humans, Infant, Japan, Male, Psychometrics, Reproducibility of Results, Surveys and Questionnaires, Quality of Life, Testicular Neoplasms therapy
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Objective: To validate the Japanese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Testicular Cancer 26 in Japanese-speaking testicular cancer survivors., Methods: A total of 200 testicular cancer survivors were recruited at eight high-volume institutions in Japan. The participants completed the Japanese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Testicular Cancer 26, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 and the International Index of Erectile Function 15 questionnaires. A total of 40 participants completed a retest of the questionnaires 2 weeks after the first response. The psychometric properties of the Japanese version including test-retest reliability, internal consistency and concurrent validity were evaluated., Results: The mean age at response was 43 years (range 22-74 years), and the mean period after treatment was 77 months (range 0-416 months). The response rate for each item, except sexual function, was high, and the percentage of missing values was less than 3.5%. For test-retest reliability, seven of 12 scales met the criteria (intraclass correlation 0.70-0.86). For internal consistency, four of seven scales met the criteria (Cronbach's alpha 0.62-0.91). For concurrent validity, treatment side effects of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Testicular Cancer 26 were related to some domains of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30. The sex-related subscales of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Testicular Cancer 26 were moderately correlated with some International Index of Erectile Function 15 domains., Conclusions: The psychometric properties of the Japanese version are equivalent to the properties of the original European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Testicular Cancer 26. The Japanese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Testicular Cancer 26 questionnaire is a useful tool to assess the health-related quality of life of testicular cancer patients., (© 2020 The Japanese Urological Association.)
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- 2021
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10. Editorial Comment from Dr Ukimura to Magnetic resonance imaging/transrectal ultrasonography fusion targeted prostate biopsy finds more significant prostate cancer in biopsy-naïve Japanese men compared with the standard biopsy.
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Ukimura O
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- Humans, Image-Guided Biopsy, Japan, Magnetic Resonance Imaging, Male, Ultrasonography, Prostatic Neoplasms
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- 2020
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11. Prostate cancer meeting the Japanese active surveillance criteria and diagnosed by community-based prostate-specific antigen screening: A 21-year follow-up study.
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Hongo F, Okihara K, Kitamura K, Fujihara A, Yamada Y, Shiraishi T, Konishi E, and Ukimura O
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- Aged, Early Detection of Cancer methods, Follow-Up Studies, Humans, Japan epidemiology, Male, Mass Screening methods, Middle Aged, Neoplasm Grading, Prostatic Neoplasms blood, Prostatic Neoplasms pathology, Registries statistics & numerical data, Risk Assessment methods, Risk Assessment statistics & numerical data, Risk Factors, Watchful Waiting methods, Early Detection of Cancer statistics & numerical data, Kallikreins blood, Mass Screening statistics & numerical data, Prostate-Specific Antigen blood, Prostatic Neoplasms diagnosis, Watchful Waiting statistics & numerical data
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Objectives: To evaluate the oncological outcomes of Japanese patients with prostate cancer diagnosed by community-based prostate-specific antigen screening during a 21-year period who satisfied the criteria for active surveillance., Methods: Active surveillance candidates were extracted from the community-based screening registry of Otokuni district in Kyoto prefecture. The frequency of active surveillance candidates before and after publication of the active surveillance criteria in Japan was analyzed. In addition, we examined the frequency of switching to curative intervention and treatment failure among active surveillance candidates, including the patients who selected active surveillance., Results: During the study period, 868 patients were diagnosed with prostate cancer and 780 of these patients were analyzed. Among them, 190 patients (24%) satisfied our active surveillance criteria (21 and 169 in the pre-active surveillance era and active surveillance era, respectively). Of the 169 patients in the active surveillance era, 74 initially selected active surveillance. The number of active surveillance candidates increased with increasing age, and the proportion of active surveillance candidates among prostate cancer patients also increased significantly each year (P < 0.001). In the active surveillance group, the median follow-up period was 4 years and 35% switched to curative intervention. Among the 190 active surveillance candidates, seven died of other causes, but there were no deaths from prostate cancer., Conclusions: Changes of active surveillance candidates in one district of Japan were successfully analyzed by using consistent active surveillance selection criteria and data obtained by a single pathologist. Oncological outcomes were good among active surveillance candidates in the low-risk group., (© 2019 The Japanese Urological Association.)
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- 2019
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12. Magnetic resonance imaging/transrectal ultrasound fusion-targeted prostate biopsy using three-dimensional ultrasound-based organ-tracking technology: Initial experience in Japan.
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Yamada Y, Fujihara A, Shiraishi T, Ueda T, Yamada T, Ueno A, Inoue Y, Kaneko M, Kamoi K, Hongo F, Okihara K, and Ukimura O
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- Adult, Aged, Aged, 80 and over, Humans, Japan, Male, Middle Aged, Neoplasm Grading, Prostate diagnostic imaging, Prostate-Specific Antigen blood, Prostatic Neoplasms diagnostic imaging, Rectum, Retrospective Studies, Endosonography, Image-Guided Biopsy methods, Magnetic Resonance Imaging, Prostate pathology, Prostatic Neoplasms diagnosis
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Objective: To evaluate the impact of magnetic resonance imaging/transrectal ultrasound fusion-targeted prostate biopsy on the diagnosis of clinically significant prostate cancer using real-time three-dimensional ultrasound-based organ-tracking technology., Methods: The present study was a retrospective review of 262 consecutive patients with prostate-specific antigen of 7.1 ng/mL (interquartile range 4.0-19.8). All patients received pre-biopsy magnetic resonance imaging and had a suspicious lesion for clinically significant prostate cancer. All patients underwent a combination of systematic biopsy (6 cores) and three-dimensional ultrasound-based magnetic resonance imaging/transrectal ultrasound fusion-targeted biopsy (2 cores). The positive rate of any cancer, positive rate of clinically significant prostate cancer, Gleason score and maximum cancer core length were compared between systematic biopsy versus magnetic resonance imaging/transrectal ultrasound fusion-targeted prostate biopsy., Results: Overall, the positive rate of any cancer per patient was 61% (160/262) in systematic biopsy versus 79% (207/262) in magnetic resonance imaging/transrectal ultrasound fusion-targeted biopsy (P < 0.0001); and that of clinically significant prostate cancer per patient was 46% (120/262) in systematic biopsy versus 70% (181/262) in magnetic resonance imaging/transrectal ultrasound fusion-targeted biopsy (P < 0.0001). The positive rate of any cancer per core was 21.7% (330/1523) in systematic biopsy versus 68.6% (406/592) in magnetic resonance imaging/transrectal ultrasound fusion-targeted biopsy (P < 0.0001), and that of clinically significant prostate cancer per core was 12.7% (193/1423) in systematic biopsy versus 60.3% (357/592) in magnetic resonance imaging/transrectal ultrasound fusion-targeted biopsy (P < 0.0001). Adding systematic biopsy leads to 13 more cancer cases (5%). The distribution of Gleason score (6/7/8/9/10) was 59/71/23/6/1 in systematic biopsy versus 48/105/36/15/2 in magnetic resonance imaging/transrectal ultrasound fusion-targeted biopsy (P = 0.005). The maximum cancer core length was 5 mm (0.5-16) in systematic biopsy versus 8 mm (1-19 mm) in magnetic resonance imaging/transrectal ultrasound fusion-targeted biopsy (P < 0.0001)., Conclusions: Three-dimensional ultrasound-based magnetic resonance imaging/transrectal ultrasound fusion-targeted biopsy seems to be associated with a higher detection rate of clinically significant prostate cancer, with fewer cores than systematic random biopsy. However, significant cancer can still be detected by the systematic technique only. A combination of systematic biopsy with the targeted biopsy technique would avoid the underdiagnosis of clinically significant prostate cancer., (© 2019 The Japanese Urological Association.)
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- 2019
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13. Chemotherapy for metastatic testicular cancer: The first nationwide multi-institutional study by the Cancer Registration Committee of the Japanese Urological Association.
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Shiraishi T, Nakamura T, and Ukimura O
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- Aged, Aged, 80 and over, Biomarkers, Tumor blood, Cisplatin therapeutic use, Combined Modality Therapy, Humans, Japan epidemiology, Male, Middle Aged, Multivariate Analysis, Neoplasm Metastasis, Neoplasm Staging, Proportional Hazards Models, Registries, Survival Rate, Testicular Neoplasms pathology, Antineoplastic Agents therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Testicular Neoplasms drug therapy
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Objectives: To assess clinicopathological data and oncological outcomes focused on metastatic testicular cancer patients, who received chemotherapy as the initial treatment, in the nationwide multi-institutional study by the Cancer Registration Committee of the Japanese Urological Association., Methods: A testicular cancer survey was carried out by the Japanese Urological Association in 2011 to register newly diagnosed testicular cancers in 2005 and 2008. Among 1121 registered patients, 278 patients with metastases who received chemotherapy as the initial treatment and could be categorized by the Japanese Urological Association classification were eligible for the analysis., Results: As first-line chemotherapy, bleomycin, etoposide and cisplatin, and etoposide and cisplatin therapies were chosen for 260 patients (93.5%). As second-line therapy, vinblastine, ifosfamide and cisplatin/etoposide, ifosfamide and cisplatin; and paclitaxel, ifosfamide and cisplatin/paclitaxel, ifosfamide and nedaplatin therapies were carried out in 23 out of 63 (36.5%) and 29 out of 63 (46.0%) patients, respectively. The response rate and serum tumor marker normalization rate were 93.4% and 81.3% at first line, 75.4% and 60.7% at second line, and 41.7% and 16.7% at third line, respectively. The Japanese Urological Association classification (≥IIIB2 vs ≤IIIB1) and choriocarcinoma component in primary histology were independent prognostic factors of overall survival before starting chemotherapy. Furthermore, in patients with non-seminomatous germ cell tumors, serum tumor marker normalization was an independent factor that was associated with better outcome of overall survival after completion of the initial series of chemotherapies., Conclusions: The initial accurate diagnosis and risk stratification is an important prognostic factor to achieve better oncological outcomes. In patients with non-seminomatous germ cell tumors, aiming for serum tumor marker normalization with continuous sequential chemotherapy could improve overall survival., (© 2018 The Japanese Urological Association.)
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- 2018
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14. Quantitative evaluation of lower urinary tract symptoms using a visual analog scale in men undergoing permanent brachytherapy.
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Okihara K, Ukimura O, Ushijima S, Kamoi K, Iwata T, Kobayashi K, Naitoh Y, Yamazaki H, Kawauchi A, and Miki T
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- Aged, Aged, 80 and over, Comorbidity, Humans, Japan epidemiology, Male, Middle Aged, Prevalence, Prognosis, Prostatic Neoplasms epidemiology, Radiation Injuries epidemiology, Reproducibility of Results, Risk Assessment, Sensitivity and Specificity, Surveys and Questionnaires, Treatment Outcome, Urologic Diseases epidemiology, Brachytherapy statistics & numerical data, Pain Measurement, Prostatic Neoplasms diagnosis, Prostatic Neoplasms radiotherapy, Quality of Life, Radiation Injuries diagnosis, Urologic Diseases diagnosis
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Purpose: A previous study showed that a visual analog scale (VAS) that measures quality of life (QOL) in relation to each of the seven items on the International Prostate Symptom Score (IPSS) was found to be significantly more able to identify a patient's chief complaint. The aim of this study was to assess the two questionnaires with special reference to the symptom that the patient most wants treated via the concomitant use of the IPSS and VAS after permanent brachytherapy (PBT)., Methods and Materials: A total of 156 men undergoing PBT were enrolled. The IPSS and VAS were evaluated at the preimplantation stage and at 1-3 months, 6-9 months, and 1 year after PBT. The correlations between the IPSS-QOL score and the total for the 14 symptoms questions included in the IPSS and VAS were statistically calculated. Multivariate analysis was used to investigate which factors could be used to predict the IPSS-QOL after PBT., Results: The correlation coefficients between the IPSS-QOL score and the seven questions on the VAS were higher than those between the IPSS-QOL and the seven questions on the IPSS. Multivariate analysis showed that the strongest factor for determining IPSS-QOL at each time point was nocturia on the VAS., Conclusions: The VAS scale reflected the change in the patients' QOL more precisely than the IPSS, which examines the frequency of lower urinary tract symptoms. Nocturia plays a key role in determining QOL. VAS could be a promising tool for assessing satisfaction in patients with lower urinary tract symptoms after PBT., (Copyright © 2012 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.)
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- 2012
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15. [Trends of decision making for primary local therapy of prostate cancer: comparative analysis between Japan and foreign countries].
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Ukimura O
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- Aged, Aged, 80 and over, Humans, Informed Consent standards, Japan, Male, Middle Aged, Decision Making, Prostatic Neoplasms therapy
- Published
- 2011
16. Impact of convenience void in a bladder diary with urinary perception grade to assess overactive bladder symptoms: a community-based study.
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Honjo H, Kawauchi A, Nakao M, Ukimura O, Kitakoji H, and Miki T
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- Adult, Aged, Aged, 80 and over, Female, Humans, Japan, Mass Screening methods, Middle Aged, Predictive Value of Tests, Severity of Illness Index, Terminology as Topic, Time Factors, Urinary Bladder, Overactive complications, Urinary Bladder, Overactive physiopathology, Urinary Bladder, Overactive psychology, Urinary Incontinence, Urge physiopathology, Urinary Incontinence, Urge psychology, Urodynamics, Perception, Sensation, Urinary Bladder physiopathology, Urinary Bladder, Overactive diagnosis, Urinary Incontinence, Urge etiology
- Abstract
Aim: Bladder diaries including bladder perception grade were analyzed to assess convenience void (CV) in community-dwelling women 40 years of age or older., Methods: A total of 310 women completed a 3-day bladder diary with a grade for bladder perception. The grade was defined on scores 0-5 as follows: 0 = No bladder sensation, 1 = Sensation of bladder filling without desire to void, 2 = Desire to void, 3 = Strong desire to void, 4 = Urgency without urge urinary incontinence (UUI), and 5 = Urge incontinence episode. CV was defined as void without desire to void: when the grade was 0, CV in a narrow sense, and when 0 or 1, CV in a broad sense., Results: The incidence of CV in the broad sense significantly decreased with age. Of the 310 women, 48 (15.5%) had overactive bladder (OAB) symptoms on the medical interview, including 37 (11.9%) without UUI (OAB-Dry) and 11 (3.5%) with UUI (OAB-Wet). Of the remaining 262 women, 111 (35.8%), who had urgency but a urinary frequency of 7 or less, and another 141 (48.7%) were classified into the Normal with Urgency and Normal without Urgency groups, respectively. The incidence of CV in a broad sense in the Normal without Urgency group was significantly greater than that in the Normal with Urgency and OAB-Wet groups. The mean voided volumes of CV in the broad sense in the OAB-Wet group were significantly smaller than those in the other three groups., Conclusions: The evaluation of CV may be a new tool in assessing storage condition and voiding dysfunction., (© 2010 Wiley-Liss, Inc.)
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- 2010
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17. Community-based prostate cancer screening in Japan: predicting factors for positive repeat biopsy.
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Okada K, Okihara K, Kitamura K, Mikami K, Ukimura O, Kawauchi A, Kamoi K, Nakao M, and Miki T
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- Aged, Biopsy statistics & numerical data, Forecasting, Humans, Japan, Male, Mass Screening, Middle Aged, Prostate pathology, Prostatic Neoplasms pathology
- Abstract
Objectives: To assess possible predictors in determining criteria for repeat biopsy in a prostate cancer screening population., Methods: A total of 50 207 men over 55 years-of-age have participated in a prostate cancer screening program in Otokuni, Kyoto, Japan for 12 years. Transperineal systematic biopsy was carried out in case of positive digital rectal examination (DRE) or positive transrectal ultrasonography (TRUS) or a prostate-specific antigen (PSA) value greater than 10.0 ng/mL. For those with a PSA level from 4.1 to 10.0 ng/mL, and negative DRE and TRUS findings, biopsy was indicated only when PSA density (PSAD) was greater than 0.15. The same indication was applied for the repeat biopsy., Results: A repeat biopsy after an interval of more than 2 years was carried out in 140 patients and was positive in 50 (36%) patients. The PSA value at the diagnosis of cancer declined from the initial value in six (12%) patients. On multivariate logistic regression analysis, PSA velocity (PSAV) as well as PSAD and DRE findings at latest screening were independent predictors for positive repeat-biopsy outcome. The odds ratio (95% confidence intervals) of PSAV >0.48, latest PSAD >0.33 and positive latest DRE were 4.17 (1.05-18.5), 4.15 (1.31-14.0), and 3.62 (1.06-13.2), respectively. A combination of three variables defined as positive if any of these were positive, reduced 31% of unnecessary biopsies while missing 8% of low volume, low grade cancers., Conclusions: A combination of latest PSAD, PSAV and positive DRE at latest screening might help to reduce unnecessary repeat biopsies in high-risk patients with an initial negative biopsy.
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- 2010
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18. Current trends in diagnostic and therapeutic principles for prostate cancer in Japan.
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Okihara K, Shiraishi T, Ukimura O, Mizutani Y, Kawauchi A, and Miki T
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- Adult, Aged, Aged, 80 and over, Biopsy, Needle, Data Collection, Humans, Japan, Male, Middle Aged, Prostate-Specific Antigen blood, Prostatectomy, Urology, Prostatic Neoplasms diagnosis, Prostatic Neoplasms therapy
- Abstract
Background: This study aimed to clarify characteristics of the diagnosis and treatment of prostate cancer in Japan., Methods: In September 2005, questionnaire surveys were mailed to Japanese urologists (response rate, 43%; 474/1090) who were listed as voting members (VMs) of the Japanese Urological Association (JUA); the questionnaire surveys were also mailed to professors and chairmen (PCs) of urology departments at Japanese national, public, and private universities who were also VMs of the JUA (response rate, 76%; 68/90). The questionnaires asked about beliefs and practices regarding prostate cancer management., Results: The answers of the VMs and PCs to the questionnaire were very similar. About 60% of these urologists answered that they did not set an age limit for prostate-specific antigen (PSA) testing, and about 40% answered that they did not set an age limit for prostate needle biopsy in individuals with an intermediately elevated PSA level. The age limit for radical prostatectomy (RP) was set at 75 years by 69% (322/470) of the VMs and 66% (45/68) of the PCs. The order of priority of factors considered for the selection of RP for early prostate cancer was radicality, including tumor grade (mean, 1.97); patient's wish for radical surgery (mean, 2.47); comorbidity (mean, 2.72); and age (mean, 2.81)., Conclusion: There are trends in diagnostic and therapeutic principles for prostate cancer which are characteristic of Japan, and these trends are associated with the recent rapid extension of life expectancy in that country.
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- 2008
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19. Broadcast of live endoscopic surgery from Korea to Japan using the digital video transport system.
- Author
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Eto M, Lee TY, Gill IS, Koga H, Tatsugami K, Shimizu S, Ukimura O, and Naito S
- Subjects
- Equipment Design, Humans, Japan, Korea, Male, Middle Aged, Quality Indicators, Health Care, Carcinoma, Renal Cell surgery, Kidney Neoplasms surgery, Laparoscopy methods, Nephrectomy methods, Telemetry instrumentation, Video Recording instrumentation
- Abstract
Purpose: To assess the quality of sound and uncompressed images during an international broadcast of live surgery using the newly developed digital video transport system (DVTS)., Methods: Three networks connected hospitals in Seoul, Korea, and Fukuoka, Japan. A teleconference system with bidirectional transmission over the network was set up. DVTS was used to send and receive visual and audio signals during a live broadcast of a laparoscopic partial nephrectomy to viewers at the 94th annual meeting of the Japanese Urological Association. A questionnaire was used to assess the quality of images and sound., Results: Of 713 questionnaires distributed, 418 were collected. The quality of image and voice was ranked very good or good by 95% and 92% of the audience, respectively. The quality of live surgery was considered high by 94% of the audience., Conclusion: Digital video images can be transformed directly to an Internet protocol without compression of the motion images using DVTS. Live surgery via teleconference using DVTS can help surgeons learn the skills of endoscopic surgery.
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- 2007
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20. Clinical efficacy of alternative antiandrogen therapy in Japanese men with relapsed prostate cancer after first-line hormonal therapy.
- Author
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Okihara K, Ukimura O, Kanemitsu N, Mizutani Y, Kawauchi A, and Miki T
- Subjects
- Aged, Aged, 80 and over, Antineoplastic Agents, Hormonal therapeutic use, Gonadotropin-Releasing Hormone agonists, Humans, Japan, Male, Middle Aged, Survival Rate, Treatment Failure, Androgen Antagonists therapeutic use, Neoplasm Recurrence, Local drug therapy, Prostatic Neoplasms drug therapy
- Abstract
Background: To confirm the effectiveness of alternative antiandrogen therapy (AAT) in Japanese patients with prostate cancer relapse after first-line hormonal therapy., Methods: A total of 80 patients who had successive serum prostate-specific antigen (PSA) progression after first-line hormonal therapy (luteinizing hormone-releasing hormone agonist alone: 21 cases; combined antiandrogen blockade therapy: 59 cases) were enrolled. We evaluated the positive ratio of antiandrogen withdrawal syndrome (AWS), the PSA responses with second- and third-line AAT, and cause-specific survival in terms of the effectiveness of AAT., Results: The overall positive AWS ratio after first-line therapy was 33%, while that after second-line therapy was 7%. There was no correlation between the first-line PSA response and the positive AWS. Of the 10 positive and the 20 negative AWS cases, secondary antiandrogen administration was effective in 50% and 60% of cases, respectively. The positive PSA responders at second- and third-line therapy were 51% and 13%, respectively. For second-line therapy, the effective rates from steroidal to non-steroidal, from non-steroidal to non-steroidal antiandrogen, and from non-steroidal to steroidal were 83%, 43%, and 14%, respectively. The cause-specific survival of the second-line responders was significantly better than that of the non-responders., Conclusion: There was a substantial number of patients who found second-line AAT to be modestly effective. Flutamide was effective as an alternative antiandrogen for the patients' relapse treatment with bicalutamide in Japanese men.
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- 2007
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21. Complexed PSA improves prostate cancer detection: results from a multicenter Japanese clinical trial.
- Author
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Okihara K, Ukimura O, Nakamura T, Ushijima S, Mizutani Y, Kawauchi A, Naya Y, Kojima M, and Miki T
- Subjects
- Aged, Humans, Japan, Male, Sensitivity and Specificity, Prostate-Specific Antigen blood, Prostatic Neoplasms blood, Prostatic Neoplasms diagnosis
- Abstract
Objectives: To compare the distribution of total and complexed prostate-specific antigen (cPSA) in men with and without prostate cancer with another studied population and to ascertain whether cPSA could enhance the detection of prostate cancer in Japanese men., Methods: A total of 760 men whose serum total PSA (tPSA) values ranged from 1.0 to 100 ng/mL were enrolled. Serum samples for tPSA and cPSA (ADVIA Centaur) were obtained in all cases. The area under the curve was calculated for comparison of the tPSA and cPSA values. We calculated the number of cancers missed and false-positive results at various cutoff values of cPSA compared with the conventional tPSA threshold of 4.0 ng/mL., Results: Prostate cancer was detected in 268 (35.3%) of 760 patients. cPSA was greater than 8.3 ng/mL (equivalent to 10.0 ng/mL tPSA) in 46.6% of the men with cancer. The area under the curve for cPSA (0.741) was significantly better than that for tPSA (0.721, P <0.001). At a sensitivity of 85% to 95%, significant differences were found in the corresponding specificity between tPSA and cPSA. cPSA at a 3.0-ng/mL threshold detected an identical number of cancers as a tPSA cutoff of 4.0 ng/mL; however, it decreased the false-positive results by 28 cases., Conclusions: To our knowledge, this is the first report of the distribution of cPSA in Japanese men using a urologic referral population. cPSA can be an alternative to tPSA as the first screening test. A substantial number of men in Japan with prostate cancer are currently diagnosed with a tPSA value greater than 10.0 ng/mL.
- Published
- 2006
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22. Learning curve of hand-assisted retroperitoneoscopic nephrectomy in less-experienced laparoscopic surgeons.
- Author
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Kawauchi A, Fujito A, Soh J, Yoneda K, Ukimura O, Mizutani Y, and Miki T
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Insufflation, Japan, Kidney Neoplasms surgery, Male, Middle Aged, Time Factors, Ureteral Neoplasms surgery, Clinical Competence, Laparoscopy methods, Nephrectomy methods
- Abstract
Aim: To evaluate the learning curve of hand-assisted retroperitoneoscopic nephrectomy (HALS) performed by less-experienced surgeons., Methods: The operative records of 166 patients, including 103 with renal tumors and 63 with renal pelvic or ureteral tumors, who underwent HALS performed by 18 less-experienced urologists were reviewed., Results: The insufflation time in the first four cases was significantly longer than that in the sixteenth and later cases. The insufflation time in cases 5-10 was 14-24 min longer than that in the cases 16 onward, although the differences were not significant. The estimated blood loss did not differ in each group of cases. The complication rate in early cases, in which the operators' experience was five cases or less, was 6% (4/71), while that in later cases was also 7% (7/95). In the analysis of the learning curve of a single surgeon who performed 57 procedures, the insufflation time in cases 1-5 was significantly longer than in cases 41-57. The insufflation times in cases 5-10 were 45 min longer than those in cases 41-57, although the difference was not significant. The estimated blood loss did not differ in each group of cases. Complications did not seem related to operation experience., Conclusion: In HALS, 5-10 cases were necessary for less-experienced urologists to gain average operating skills for this procedure. It may be reasonable for less-experienced surgeons to begin standard laparoscopic procedures after experiencing 10 cases of the present procedure.
- Published
- 2005
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23. Can complexed prostate specific antigen enhance prostate cancer detection in Japanese men?
- Author
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Okihara K, Ukimura O, Nakamura T, Mizutani Y, Kawauchi A, Naya Y, Uchida M, Ogiwara T, and Miki T
- Subjects
- Aged, Aged, 80 and over, Asian People, Humans, Japan, Male, Middle Aged, Sensitivity and Specificity, Prostate-Specific Antigen blood, Prostatic Neoplasms blood, Prostatic Neoplasms diagnosis
- Abstract
Background: The aim of this study is to ascertain whether Bayer complexed PSA (cPSA) and volume referenced cPSA could enhance the detection of prostate cancer in Japanese men., Methods: A total of 214 Japanese men whose serum total PSA (tPSA) values ranged from 1.2 ng/ml to 4600 ng/ml were enrolled from two institutions. Serum samples for tPSA, free PSA, PSA-alpha-1-antichymotripsin (PSA-ACT) and cPSA (ADVIA-Centaur) were obtained in all cases. In addition, total gland (TGV) as well as transition zone volume (TZV) were determined in all cases who underwent untrasound guided prostate biopsy (sextant and two additional transition zone biopsies). Biopsy outcome was correlated to the following parameters: tPSA, cPSA, PSA-ACT, free to total (F/T) PSA ratio, 2 complex to total (C/T) PSA ratios and 6 volume referenced parameters., Results: Prostate cancer was detected in 85 of 214 patients (40%). The area under the receiver operating characteristic curve in non-volume referenced variables was highest for cPSA (0.736), followed by PSA-ACT (0.735), tPSA (0.722), F/T PSA ratio (0.613) and C/T PSA ratio (0.591). Comparing tPSA with the cutoff value of 4.0 ng/ml, the cutoff value with a 2.8 ng/ml of cPSA detected one more positive biopsy patient, decreasing one more cancer missed case and 8 more false positive cases. At sensitivities of 85% to 95% in men with tPSA between 4.00 and 10.00 ng/ml (n = 116), there were no significant differences in the corresponding specificities between tPSA and cPSA, or between cPSA and PSA-ACT. At sensitivities of 90% to 95%, the corresponding specificities of PSA-ACT adjusted for transition zone volume revealed best performance. As for the performance in men with a tPSA less than 4.0 ng/ml, the specificities of cPSA performed best, and differed significantly from PSA-ACT and F/T PSA at sensitivities of 80% to 90%., Conclusion: Bayer cPSA could replace the first screening test by total PSA and can enhance cancer detection, compared with PSA-ACT. However, cPSA did not provide additional value in differentiating cancer from non-cancer cases in men with a tPSA between 4.00 and 10.00 ng/ml., (Copyright 2003 Elsevier B.V.)
- Published
- 2004
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- View/download PDF
24. [A statistical study of benign prostatic hyperplasia in Japan].
- Author
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Ukimura O, Kawauchi A, and Miki T
- Subjects
- Age Factors, Humans, Japan epidemiology, Male, Mass Screening, Morbidity, Prostatic Hyperplasia diagnosis, Prostatic Hyperplasia therapy, Quality of Life, Reference Standards, Time Factors, Urination Disorders etiology, Prostatic Hyperplasia epidemiology
- Published
- 2002
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