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Red-crowned cranes (Grus japonensis) are distributed separately in the east Eurasian Continent (continental population) and in Hokkaido, Japan (island population). The island population is sedentary in eastern Hokkaido and has increased from a very small number of cranes to over 1,300, thus giving rise to the problem of poor genetic diversity. While, Hooded cranes (Grus monacha), which migrate from the east Eurasian Continent and winter mainly in Izumi, Kagoshima Prefecture, Japan, are about eight-time larger than the island population of Red-crowned cranes. We collected whole bodies of these two species, found dead or moribund in eastern Hokkaido and in Izumi, and observed skeletons with focus on vertebral formula. Numbers of cervical vertebrae (Cs), thoracic vertebrae (Ts), vertebrae composing the synsacrum (Sa) and free coccygeal vertebrae (free Cos) in 22 Red-crowned cranes were 17 or 18, 9-11, 13 or 14 and 7 or 8, respectively. Total number of vertebrae was 47, 48 or 49, and the vertebral formula was divided into three types including 9 sub-types. Numbers of Cs, Ts, vertebrae composing the Sa and free Cos in 25 Hooded cranes were 17 or 18, 9 or 10, 12-14 and 6-8, respectively. Total number of vertebrae was 46, 47, 48 or 49, and the vertebral formula was divided into four types including 14 sub-types. Our findings clearly showed various numerical vertebral patterns in both crane species; however, these variations in the vertebral formula may be unrelated to the genetic diversity.

A 33 month-old male flying squirrel kept in a zoo developed progressive dyspnea and died. Macroscopically, the liver and lung were enlarged with numerous nodular vesicles. Histologically, these organs were replaced by numerous collapsed vesicles demarcated by fibrous tissues. The cysts lined by a cellular, germinal layer contained numerous brood capsules with abundant production of well-developed protoscolices. Protoscolices were about 80-100 μm in diameter, and had hooks being visible as refractive structures. This zoo locates in the east of Hokkaido where is an endemic area of Echinococcus multilocularis infection. From epidemiology and pathological findings, this animal was diagnosed as E.multilocularis infection. This report describes the pathology of the first case of E. multilocularis infection in a flying squirrel.

Red-crowned (or Japanese) cranes Grus japonensis are native to eastern Hokkaido, Japan--the island population, and mainland Asia--the continental population that migrates from breeding grounds along the Amur River Basin to winter in east China and the Korean Peninsula. The island population was reduced to about 50-60 birds in early part of the 20th century. Since 1950s, the population has increased to more than 1,300 as a consequence of human-provided food in winter, resulted in change of their habitats and food resource. From the carcasses of 284 wild cranes from the island population, collected in Hokkaido since 1976 until 2010, we measured six physical parameters (body weight and lengths of body, wing, tarsus, tail and exposed culmen) and divided into groups by sex and three developmental stages (juvenile, yearling and adult). All parameters of males were larger than those of females at the same stage. Total body length of females tends to grow up earlier than males, in contrast to body weight. Obvious time trends were not observed in these all parameters during 34 years for these six categories measured, except total length of male juveniles, which showed a significant increasing trend. These results provide the first extensive data on body size and mass in the wild red-crowned cranes.

Red-crowned cranes (Grus japonensis) are native to eastern Hokkaido (island population), in contrast to the mainland, which migrates between the Amur River basin and eastern China-Korea peninsula. During the 1990s we found that Red-crowned cranes in Hokkaido were highly contaminated with mercury: however, the source was unknown. We investigated the time trend of mercury contamination in Red-crowned cranes. Total mercury levels in the livers and kidneys from cranes dead in the 2000s were lower than those dead in the 1990s. Feather is a major pathway of mercury excretion for many bird species and is used as an indicator of blood mercury level during feather growth. As internal organs from the specimens collected before 1988 were not available, we analyzed the flight feather shavings from stuffed Red-crowned cranes dead in 1959-1987 and found that the mercury level of feathers from cranes dead in the 1960s and 1970s was not more than those from the cranes dead in the 2000s. These results suggest that mercury contamination in Red-crowned cranes in Hokkaido decreased temporally during the 1990s-2000s. This indicates the possible occurrence of some mercury pollution in Red-crowned cranes' habitat in this region in the 1990s or before.

Purpose: To observe the current situation of tuberculosis and its control measures in hemodialysis facilities in Chiba Prefecture, Japan., Method: Questionnaires on medical dialysis and tuberculosis were sent to hemodialysis facilities in Chiba Prefecture., Results: The questionnaires were answered by 55 of 127 facilities. Of the respondents, 46 (83.6%) were not aware of the recommendation of treatment for latent tuberculosis infections in Japanese patients. Moreover, 30 (54.5%) facilities did not examine patients for tuberculosis prior to the initiation of hemodialysis. Of the 21 facilities that did assess patients for tuberculosis infection, only 5 (23.8%) performed a tuberculin skin test or QuantiFERON TB-2G. Three of the five (60.0%) that were treating tuberculosis by themselves expressed fear or uncertainty about the diagnosis and treatment of latent tuberculosis infections. During January 2006 through December 2007, tuberculosis patients were detected in 11 facilities, and the proportion of extrapulmonary tuberculosis among these patients was 52.4%. Seven facilities reported that they took no control measures against tuberculosis., Conclusion: It is important to inform medical dialysis facilities about latent tuberculosis infections, the early diagnosis of tuberculosis, and the combination of nosocomial infection control. It is also important for experts in hemodialysis and tuberculosis to work closely together.

Purpose: To examine the clinical problems of died cases with pulmonary tuberculosis., Methods: Clinical findings of 52 patients with active pulmonary tuberculosis, who had died in our hospital between April 2005 to March 2007, were analyzed., Results: Mean age was 72.3 10.6 years old, 9 cases (17.3 %) were relapsed, and 35 cases (67.3%) had cavity on the chest X-ray. 34 cases (65.4%) were PS4 and none was PS0 or PS1 on admission. Complications were malignancy in 11 cases, diabetes mellitus in 10 cases, and respiratory diseases in 6 cases. 15 cases (28.8%) were treated with drugs including INH, RFP and PZA, 14 cases (26.9%) with drugs including INH and RFP, 16 cases (30.8%) with the other drugs, and 7 cases (13.5%) were not able to be administered any drug. 35 cases (67.3%) died of tuberculosis and 17 cases (32.7%) died of non-tuberculous conditions., Conclusion: Many died cases were under very poor general condition, needed frequent care, had many kind of complications and had difficulty with standard treatment on admission. Tuberculous death were observed highly, but death by complications were observed in many cases. It is necessary to control complications and enlighten society and docters about importance of early diagnosis and treatment of tuberculosis continuously.

Little attention has been paid to neglected tropical diseases (NTDs) in high-income countries and no literature provides an overview of NTDs in Japan. This scoping review aims to synthesize the latest evidence and information to understand epidemiology of and public health response to NTDs in Japan. Using three academic databases, we retrieved articles that mentioned NTDs in Japan, written in English or Japanese, and published between 2010 and 2020. Websites of key public health institutions and medical societies were also explored. From these sources of information, we extracted data that were relevant to answering our research questions. Our findings revealed the transmission of alveolar echinococcosis, Buruli ulcer, Chagas disease, dengue, foodborne trematodiases, mycetoma, scabies, and soil-transmitted helminthiasis as well as occurrence of snakebites within Japan. Other NTDs, such as chikungunya, cystic echinococcosis, cysticercosis, leishmaniasis, leprosy, lymphatic filariasis, rabies, and schistosomiasis, have been imported into the country. Government agencies tend to organize surveillance and control programs only for the NTDs targeted by the Infectious Disease Control Law, namely, echinococcosis, rabies, dengue, and chikungunya. At least one laboratory offers diagnostic testing for each NTD except for dracunculiasis, human African trypanosomiasis, onchocerciasis, and yaws. No medicine is approved for treatment of Chagas disease and fascioliasis and only off-label use drugs are available for cysticercosis, opisthorchiasis, human African trypanosomiasis, onchocerciasis, schistosomiasis, and yaws. Based on these findings, we developed disease-specific recommendations. In addition, three policy issues are discussed, such as lack of legal frameworks to organize responses to some NTDs, overreliance on researchers to procure some NTD products, and unaffordability of unapproved NTD medicines. Japan should recognize the presence of NTDs within the country and need to address them as a national effort. The implications of our findings extend beyond Japan, emphasizing the need to study, recognize, and address NTDs even in high-income countries. Author summary: Neglected tropical diseases (NTDs) are an umbrella term for 20 diseases and disease groups recognized by the World Health Organization. Although NTDs are usually considered to be a public health problem in low- and middle-income countries, people living in high-income countries could also be affected. In this scoping review, we aimed to summarize the latest evidence and information to understand the epidemiology of and public health response to NTDs in Japan. Japan officially reported a yearly average of 340 NTD cases between 2014 and 2017; however, we found that it does not accurately reflect the current status of NTDs in the country. Our review suggests that 15 of 20 NTDs can be considered to be important public health concerns. While echinococcosis, chikungunya, dengue, and rabies are under control by law, many other NTDs are largely neglected by Japan's health systems and solely addressed by a limited number of physicians and researchers. We recommend that the Government of Japan should assume responsibility for enhancing surveillance, expanding access to diagnostics and medicines, and ensuring affordability of unapproved NTD drugs. [ABSTRACT FROM AUTHOR]

AbstractMost Japanese facilities use central dialysis fluid delivery systems (CDDS). In addition, since high-performance dialysis membranes are frequently used in Japan, the standard recommends that ultrapure dialysis fluid (UPD) should be used for all dialysis modalities at all dialysis facilities. RO produces and endotoxin retentive filters (ETRFs) occupy the most important position for UPD in this CDDS process. But ETRF is not accepted as medical equipment now in Japan. Since the logarithm reduction value (LRV) of ETRFs widely used today may be a desirable 3 for endotoxin (ET) and 7 for bacteria, UPD could be theoretically obtained through the use of ETRFs. However, we have no data of the LRV for ET and bacteria with a both new and used ETRF now. So we must study whether ETRF has this performance by doing an ET and bacterial challenge test in the near future. Also, ETRF will have to be accepted as medical equipment indicating the safety of CDDS.Copyright © 2009 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

The diel vertical distribution patterns of Japanese common squid, Todarodes pacificus, paralarvae were examined using a Multiple Opening Closing Net and Environmental Sensing System (MOCNESS) in the southwest Sea of Japan near the Oki Islands (Japan) during five late-autumn surveys in 1998–2002. A total of 1,511 paralarvae ranging in mantle length (ML) from 0.7 to 7.3 mm were collected at 63 of the 68 stations surveyed. Most (84%) were collected above 75 m depth and in the mixed layer. The vertical distribution patterns varied little between day and night. Hatchling-sized (<1.0 mm ML) paralarvae were abundant at 0–25 m depth, and paralarval ML increased with increasing sampling depth. Our results suggest that T. pacificus paralarvae do not exhibit large diel vertical migration patterns, but as they increase in size, paralarvae gradually descend in the water column and the variability in depth increases with ontogeny. [ABSTRACT FROM AUTHOR]