1. Bariatric surgery reduces oxidative stress by blunting 24-h acute glucose fluctuations in type 2 diabetic obese patients.
- Author
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Marfella R, Barbieri M, Ruggiero R, Rizzo MR, Grella R, Mozzillo AL, Docimo L, and Paolisso G
- Subjects
- Adult, Aged, Alanine Transaminase blood, Aspartate Aminotransferases blood, Bariatric Surgery, Biopsy, Body Mass Index, Diabetes Mellitus, Type 2 blood, Disease Progression, Female, Follow-Up Studies, Humans, Japan, Liver pathology, Male, Middle Aged, Obesity blood, Obesity complications, Proportional Hazards Models, Blood Glucose metabolism, Diabetes Mellitus, Type 2 complications, Fatty Liver pathology, Obesity surgery, Oxidative Stress physiology, Weight Loss
- Abstract
Objective: We evaluated the efficacy of malabsorptive bariatric surgery on daily blood glucose fluctuations and oxidative stress in type 2 diabetic obese patients., Research Design and Methods: The 48-h continuous subcutaneous glucose monitoring was assessed in type 2 diabetic patients before and 1 month after biliopancreatic diversion (BPD) (n = 36), or after diet-induced equivalent weight loss (n = 20). The mean amplitude of glycemic excursions and oxidative stress (nitrotyrosine) were evaluated during continuous subcutaneous glucose monitoring. During a standardized meal, glucagon-like peptide (GLP)-1, glucagon, and insulin were measured., Results: Fasting and postprandial glucose decreased equally in surgical and diet groups. A marked increase in GLP-1 occurred during the interprandial period in surgical patients toward the diet group (P < 0.01). Glucagon was more suppressed during the interprandial period in surgical patients compared with the diet group (P < 0.01). Mean amplitude of glycemic excursions and nitrotyrosine levels decreased more after BPD than after diet (P < 0.01)., Conclusions: Oxidative stress reduction after biliopancreatic diversion seems to be related to the regulation of glucose fluctuations resulting from intestinal bypass.
- Published
- 2010
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