1. Urinary angiotensinogen in pediatric urinary tract infection.
- Author
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Mayumi, Reina, Murano, Yayoi, Yokota, Reina, Nakao, Akihiro, Miyazaki, Nao, Hara, Taichi, Mizutani, Akira, Hayashi, Kuniyoshi, Sakurai, Yumiko, Shoji, Hiromichi, Nakazawa, Tomoyuki, and Shimizu, Toshiaki
- Subjects
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URINARY tract infection diagnosis , *KIDNEY failure , *ANGIOTENSINS , *FEVER , *HEALTH facilities , *RISK assessment , *URINARY tract infections , *RENIN-angiotensin system , *DISEASE complications , *CHILDREN , *DISEASE risk factors - Abstract
Background: Urinary tract infection (UTI) is one of the most common diseases in children, and urinary angiotensinogen (U‐AGT) is a new biomarker gathering attention in many renal diseases. U‐AGT reflects intrarenal renin–angiotensin system (RAS) activity. We conducted a study to measure U‐AGT in children <4 months old with UTI. Methods: All children <4 months old who came to Toshima Hospital with fever between January 2015 and December 2015 were included. Patients were divided into a UTI group and a non‐UTI group, and U‐AGT was measured. Results: Median U‐AGT was higher in patients with UTI compared with patients without UTI: (0.56 ng/dL, range, 0.025–2.753 ng/dL vs 0.13 ng/dL, range, 0.008–1.697 ng/dL, respectively; P < 0.05). Conclusions: U‐AGT is elevated in UTI patients, and RAS activation may contribute to renal injury caused by UTI. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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