7 results on '"Ohtsubo H"'
Search Results
2. [How EPMEWSE* worked with supporting programs for female scientists in STEM** fields in Japan].
- Author
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Ohtsubo H
- Subjects
- Data Collection, Developed Countries, Female, Humans, Japan, Male, Women's Rights, Career Mobility, Leadership, Research Personnel, Women
- Abstract
In gender equality, Japan is still lagging behind other developed nations. The ratio of female to male researchers is only at 14% in 2012, the lowest among developed countries. The Ministry of Education, Culture, Sports, Science and Technology (MEXT) in Japan has started the programs to support the female researchers and to develop their leadership activities. Our survey revealed that there are too few women in higher positions who can help younger women with career enhancement. Also, male scientists have unconscious bias when they evaluate their female colleagues. At the same time, female scientists often underestimate their ability when seeking leadership roles. The MEXT programs will only exert a long-term effect on the ratio and roles of women in science if the academic climate and leadership changes in Japan. In Japan, a long-term strategy with support by government and universities is essential to overcome the gender gap and maximize the potential of female scientists.
- Published
- 2013
3. Metabolomics analysis of umbilical cord blood clarifies changes in saccharides associated with delivery method.
- Author
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Hashimoto F, Nishiumi S, Miyake O, Takeichi H, Chitose M, Ohtsubo H, Ishimori S, Ninchoji T, Hashimura Y, Kaito H, Morisada N, Morioka I, Fukuoka H, Yoshida M, and Iijima K
- Subjects
- Cohort Studies, Female, Gas Chromatography-Mass Spectrometry, Humans, Japan, Labor, Obstetric metabolism, Pregnancy, Biomarkers blood, Cesarean Section, Fetal Blood metabolism, Labor, Induced, Labor, Obstetric physiology, Metabolomics methods, Stress, Physiological physiology
- Abstract
Background: A metabolomic approach using umbilical cord blood from infants at birth has not been studied widely yet., Aim: We examined changes in metabolite levels in umbilical cord blood at birth via gas chromatography/mass spectrometry (GC/MS)-based metabolomics, with the aim of achieving a detailed understanding of fetal stress during labor., Study Design: All procedures were reviewed and approved by the Institutional Review Board of Kobe University School of Medicine. This was a cohort study of pregnant women based in Palmore Hospital, which is located in an urban area of Japan, and was carried out between December 2010 and May 2011., Subject: Umbilical cord arterial blood samples were obtained from 41 infants immediately after delivery., Outcome Measures: Metabolites in the blood samples were measured using GC/MS to investigate whether the delivery method (spontaneous onset of labor, induction of labor or elective cesarean section) affected the metabolite profile in umbilical cord blood., Results: Elective cesarean section without labor led to lower levels of isoleucine, fructose, mannose, glucose, allose, glucuronic acid, inositol and cysteine in comparison with vaginal delivery following spontaneous labor and without medication., Conclusion: It is proposed that the stress associated with labor be involved in alterations in the levels of metabolites, particularly saccharides such as glucose, in umbilical cord blood., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF
4. Japan's lagging gender equality.
- Author
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Homma MK, Motohashi R, and Ohtsubo H
- Subjects
- Female, Humans, Japan, Male, Engineering education, Mathematics education, Science education, Sex Ratio, Technology education, Women education
- Published
- 2013
- Full Text
- View/download PDF
5. Predictors of worsening renal function after computed tomography coronary angiography: assessed by cystatin C.
- Author
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Ando H, Isobe S, Amano T, Yamada T, Ohtsubo H, Yuba M, Ishii H, and Murohara T
- Subjects
- Aged, Biomarkers blood, Comorbidity, Contrast Media, Coronary Artery Disease blood, Coronary Artery Disease diagnosis, Coronary Artery Disease epidemiology, Female, Humans, Japan epidemiology, Kidney Diseases, Kidney Function Tests, Male, Prevalence, Risk Assessment, Risk Factors, Acute Kidney Injury diagnosis, Acute Kidney Injury epidemiology, Coronary Angiography statistics & numerical data, Cystatin C blood, Iopamidol, Tomography, X-Ray Computed statistics & numerical data
- Abstract
Background: An increase in cystatin C (CyC) of ≥10% for 24 hours may predict contrast-induced nephropathy and worse outcomes in patients with renal dysfunction undergoing invasive coronary angiography., Objective: We investigated the changes in CyC in patients with preserved renal function referred for contrast-enhanced coronary computed tomography angiography (CTA)., Methods: We studied 151 patients undergoing CTA with 70 mL of iopamidol. Serum creatinine and CyC, a sensitive measure of renal dysfunction, shown to be associated with adverse outcomes, were measured 1 day and 1 week after CTA, respectively. The percentage change in CyC (%CyC) was determined and evaluated in comparison to fluid intake., Results: The patients were dichotomized into 2 groups: 47 patients had ≥10% increase in CyC 1 day after CTA (group A) and 104 did not (group B). The percentage of diabetic patients, hemoglobin A1c (HbA1c), and the CyC levels at 1 week were significantly greater, and the oral fluid volume was significantly lower in group A than in group B. The %CyC inversely correlated with oral fluid volume (r = -0.80, P < 0.0001) and positively with HbA1c (r = 0.38, P < 0.001). Multiple regression analysis showed that oral fluid intake (β = -0.796, P < 0.0001) and HbA1c (β = 0.128, P = 0.007) are independent predictors for %CyC of ≥10%., Conclusion: Frequency of CyC elevation was strongly related to hydration after the study and also weakly related to HbA1c. Sufficient oral fluid intake (oral fluid volume/kg ≥ 20 mL/kg) is crucial, particularly for poorly controlled diabetic patients referred for CTA even though they show preserved renal function., (Copyright © 2012 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.)
- Published
- 2012
- Full Text
- View/download PDF
6. Two new SINE elements, p-SINE2 and p-SINE3, from rice.
- Author
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Xu JH, Osawa I, Tsuchimoto S, Ohtsubo E, and Ohtsubo H
- Subjects
- Base Sequence, Chromosome Mapping, Cluster Analysis, Computational Biology, Japan, Molecular Sequence Data, Sequence Analysis, DNA, Sequence Homology, Species Specificity, Oryza genetics, Phylogeny, Short Interspersed Nucleotide Elements genetics
- Abstract
p-SINE1 was the first plant SINE element identified in the Waxy gene in Oryza sativa, and since then a large number of p-SINE1-family members have been identified from rice species with the AA or non-AA genome. In this paper, we report two new rice SINE elements, designated p-SINE2 and p-SINE3, which form distinct families from that of p-SINE1. Each of the two new elements is significantly homologous to p-SINE1 in their 5'-end regions with that of the polymerase III promoter (A box and B box), but not significantly homologous in the 3'-end regions, although they all have a T-rich tail at the 3' terminus. Despite the three elements sharing minimal homology in their 3'-end regions, the deduced RNA secondary structures of p-SINE1, p-SINE2 and p-SINE3 were found to be similar to one another, such that a stem-loop structure seen in the 3'-end region of each element is well conserved, suggesting that the structure has an important role on the p-SINE retroposition. These findings suggest that the three p-SINE elements originated from a common ancestor. Similar to members of the p-SINE1 family, the members of p-SINE2 or p-SINE3 are almost randomly dispersed in each of the 12 rice chromosomes, but appear to be preferentially inserted into gene-rich regions. The p-SINE2 members were present at respective loci not only in the strains of the species with the AA genome in the O. sativa complex, but also in those of other species with the BB, CC, DD, or EE genome in the O. officinalis complex. The p-SINE3 members were, however, only present in strains of species in the O. sativa complex. These findings suggest that p-SINE2 originated in an ancestral species with the AA, BB, CC, DD and EE genomes, like p-SINE1, whereas p-SINE3 originated in an ancestral strain of the species with the AA genome. The nucleotide sequences of p-SINE1 members are more divergent than those of p-SINE2 or p-SINE3, indicating that p-SINE1 is likely to be older than p-SINE2 and p-SINE3. This suggests that p-SINE2 and p-SINE3 have been derived from p-SINE1.
- Published
- 2005
- Full Text
- View/download PDF
7. Combined hereditary factor XI (plasma thromboplastin antecedent) deficiency, von Willebrand's disease, and xeroderma pigmentosum in a Japanese family.
- Author
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Sano M, Saito H, Shimamoto Y, Sugiura I, Ohtsubo H, Kohda H, and Yamaguchi M
- Subjects
- Adult, Blood Coagulation, Factor VIII analysis, Factor XI Deficiency epidemiology, Family Health, Female, Heterozygote, Humans, Japan epidemiology, Male, Pedigree, Ristocetin analysis, Xeroderma Pigmentosum epidemiology, von Willebrand Diseases epidemiology, von Willebrand Factor analysis, Asian People genetics, Factor XI Deficiency complications, Xeroderma Pigmentosum complications, von Willebrand Diseases complications
- Abstract
We report a 28-year-old-Japanese male who had a skin tumor derived from variant type xeroderma pigmentosum (XP), combined with factor XI (FXI) deficiency and type IIB von Willebrand's disease (vWd). The patient had abnormal bleeding history on tooth extraction. FXI clotting activity (FXI:C) and antigen (FXI:Ag) were remarkably decreased (< 0.01 U/ml, < 0.02 U/ml, respectively). Factor VIII (FVIII) clotting activity, von Willebrand factor antigen (vWf:Ag), and ristocetin cofactor (RCoF) were 0.43 U/ml, 45%, and 57%, respectively. Ristocetin-induced platelet agglutination (RIPA) revealed hyper-aggregation compared with a normal control. Multimeric composition of vWf in plasma showed a reduction in high molecular weight forms. The family study revealed two other subjects with homozygous hereditary FXI deficiency and vWd, and five subjects with heterozygous FXI deficiency. The relationship between FXI deficiency and vWd is discussed and previously reported cases are reviewed.
- Published
- 1993
- Full Text
- View/download PDF
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