1. Characterization of an anti-Dia antibody causing hemolytic disease in a newborn infant.
- Author
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Alves de Lima LM, Berthier ME, Sad WE, DiNapoli J, Johnson CL, and Marsh WL
- Subjects
- Binding Sites, Antibody, Blood Group Antigens genetics, Erythroblastosis, Fetal epidemiology, Erythroblastosis, Fetal immunology, Female, Humans, Infant, Newborn, Isoantibodies genetics, Isoantibodies immunology, Japan ethnology, Macrophages metabolism, Middle Aged, Pregnancy, Blood Group Antigens immunology, Erythroblastosis, Fetal etiology, Isoantibodies biosynthesis
- Abstract
A case of hemolytic disease in a newborn infant caused by anti-Dia is described. The parents are Japanese. The antibody was an IgG of subclasses IgG1 and IgG3, did not bind complement, and gave a 27 percent phagocytosis rate when used to sensitize red blood cells for a macrophage binding assay. The antibody was not detected during antenatal serologic testing. This case suggests the need for reagent red blood cell panels selected to match antibody specificities likely to be encountered in a particular population.
- Published
- 1982
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