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Background: Medial meniscal extrusion (ME) is a biomarker to predict later development of knee osteoarthritis (KOA). On the other hand, we have reported osteophyte formation at the posterior condylar notch of the femur served as a biomarker for the same purpose. The purpose of this study is to compare capacity of the two biomarkers in predicting KOA development.Methods: Two cohort of knees were established utilizing publicly available data from the Osteoarthritis Initiative (OAI). No OA group (NOA) consisted of knees that were grade 0 or 1 on Kellgren and Lawrence grade (K/L) both at baseline and 48 months later, and pre-radiographic-OA group (PROA) consisted of knees that were grade 0 or 1 at baseline but grade ≥2 48 months later. Baseline MR images were evaluated in terms of ME and osteophyte formation at the posterior condylar notch. ME was evaluated both by meniscus subluxation index (MSI) indicating the ratio of the extruded width of the medial meniscus to the width of medial meniscal body and by the medial radial displacement (MRD) indicating actual extruded width. The size of the osteophyte was assessed using a semi-quantitative whole-organ magnetic resonance imaging score (WORMS). The predictive accuracy of KOA was assessed by the area under the receiver operating characteristic curve (AUC) and optimal cutoff was determined for each parameter.Results: The AUC for MSI was 0.654 (0.561-0.748: 95% CI) and the cutoff value was determined as 17%. That for MRD was 0.677 (0.584-0.770) and the cutoff value was 2.2 mm. The AUC for the WORMS score at the posterior condylar notch was 0.667 (0.579-0.756) and the cutoff value was 2.Conclusions: Similar predicting capacity of KOA development was found both in ME and osteophyte formation at the posterior condylar notch. Using these simple parameter, mas-screening for KOA development would be possible. [ABSTRACT FROM AUTHOR]

The article discusses a study which evaluates whether revision meniscal repair can achieve good clinical outcomes. It cites the participation of 16 patients with symptomatic meniscal retears. The results showed that five patients had re-retears of a resutured meniscus, and the mean duration between revision and the re-retear was 25 months. It also cites the potential of revision meniscal repair in the setting of a retorn meniscus without degenerative changes.

PURPOSE: To investigate the repeatability of tear meniscus measurements using anterior segment sweptsource optical coherence tomography (OCT) and the relationship of tear meniscus measurements with tear film breakup time and Schirmer test results. DESIGN: Prospective, observational, cross-sectional study. METHODS: We enrolled 26 healthy subjects (26 eyes; 20 men and 6 women; mean age, 36.5 ± 6.8 years) at the University of Tokyo School of Medicine, Tokyo, Japan, in this study. Examinations were conducted in the following sequence: anterior segment vertical raster scans by swept-source OCT, tear film breakup time, and Schirmer test. Each subject underwent OCT measurements twice by the same grader, and the central upper and lower tear menisci height and area and the lower tear meniscus volume were examined. Each OCT image was evaluated by 2 masked graders using the software calipers. RESULTS: The average upper and lower tear meniscus heightswere 231 ± 78 μm and 256 ± 57μm, respectively, and the average upper and lower tear meniscus areas were 18 829 ± 7823 μm² and 21 903 ± 8173 μm², respectively. The average tear meniscus volume was 0.1327 ± 0.051 mm³. The intergrader intraclass correlations for all the parameters were more than 95%. The OCT tear meniscus measurements and the Schirmer test scores were correlated significantly (P < .05, Spearman nonparametric correlation analysis). However, tear film breakup time was not correlated signi?cantly with any of the parameters of tear menisci (P>.05). CONCLUSIONS: Anterior segment swept-source OCT is a noninvasive and practical method that can be used for quantitative evaluation of tear fluid. [ABSTRACT FROM AUTHOR]

Objective To evaluate medial radial displacement (MRD) of the medial meniscus in osteoarthritic (OA) and normal knees, with and without weight bearing, using ultrasonography (US), and to prospectively evaluate the time course of changes in MRD in OA knees. Methods The study subjects were 78 patients with OA of the knee (69% female; mean age 66.4 years) and 20 healthy, asymptomatic subjects (70% female; mean age 64.5 years) who served as a control group. The OA stage was determined according to the Kellgren/Lawrence (K/L) radiographic grading system. US measurement of MRD was performed with subjects in the supine and standing positions. With the exception of subjects who dropped out, 58 OA knees (followup rate 74%) were evaluated at baseline and ∼1 year later. Results The medial meniscus was significantly displaced radially by weight bearing in control knees ( P < 0.001) and in knees with K/L grades 1-3 OA ( P < 0.01 for each comparison). MRD in either the supine or the standing position was not significantly different between the control knees and the K/L grade 1 knees, but significant differences were noted between the control knees and K/L grade 2 or more severe OA knees ( P < 0.01 for each comparison). MRD of the medial meniscus had increased significantly on followup in all knees ( P < 0.05 for each comparison) excluding K/L grade 4 knees in the standing position. Conclusion MRD of the medial meniscus increased with weight bearing and during followup. These findings suggest a close association between extraarticular displacement of the medial meniscus and progression of OA. [ABSTRACT FROM AUTHOR]

Only a few cases of double-layered meniscus have been described in the English literature. We report two cases of bilateral double-layered lateral meniscus, where an additional semicircular meniscus was observed over the normal lateral meniscus. One of the patients exhibited a bucket-handle tear with a double-layered meniscus. To our knowledge, this abnormality is extremely rare and the incidence of double layered meniscus with bucket-handle tear has not been previously reported. [ABSTRACT FROM AUTHOR]