1. Clinicopathological features and prognosis of primary small bowel adenocarcinoma: a large multicenter analysis of the JSCCR database in Japan.
- Author
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Yamashita, Ken, Oka, Shiro, Yamada, Takeshi, Mitsui, Keigo, Yamamoto, Hironori, Takahashi, Keiichi, Shiomi, Akio, Hotta, Kinichi, Takeuchi, Yoji, Kuwai, Toshio, Ishida, Fumio, Kudo, Shin-Ei, Saito, Shoichi, Ueno, Masashi, Sunami, Eiji, Yamano, Tomoki, Itabashi, Michio, Ohtsuka, Kazuo, Kinugasa, Yusuke, and Matsumoto, Takayuki
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SMALL intestine cancer , *LARGE intestine , *DUODENAL tumors , *DATABASES , *PROGNOSIS , *RECTAL cancer , *HEREDITARY nonpolyposis colorectal cancer - Abstract
Background: The clinicopathological features and prognosis of primary small bowel adenocarcinoma (PSBA), excluding duodenal cancer, remain undetermined due to its rarity in Japan. Methods: We analyzed 354 patients with 358 PSBAs, between January 2008 and December 2017, at 44 institutions affiliated with the Japanese Society for Cancer of the Colon and Rectum. Results: The median age was 67 years (218 males, 61.6%). The average tumor size was 49.9 (7–100) mm. PSBA sites consisted of jejunum (66.2%) and ileum (30.4%). A total of 219 patients (61.9%) underwent diagnostic small bowel endoscopy, including single-balloon endoscopy, double-balloon endoscopy, and capsule endoscopy before treatment. Nineteen patients (5.4%) had Lynch syndrome, and 272 patients (76.8%) had symptoms at the initial diagnosis. The rates for stages 0, I, II, III, and IV were 5.4%, 2.5%, 27.1%, 26.0%, and 35.6%, respectively. The 5-year overall survival rates at each stage were 92.3%, 60.0%, 75.9%, 61.4%, and 25.5%, respectively, and the 5-year disease-specific survival (DSS) rates were 100%, 75.0%, 84.1%, 59.3%, and 25.6%, respectively. Patients with the PSBA located in the jejunum, with symptoms at the initial diagnosis or advanced clinical stage had a worse prognosis. However, multivariate analysis using Cox-hazard model revealed that clinical stage was the only significant predictor of DSS for patients with PSBA. Conclusions: Of the patients with PSBA, 76.8% had symptoms at the initial diagnosis, which were often detected at an advanced stage. Detection during the early stages of PSBA is important to ensure a good prognosis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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