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1. Lanostane triterpenes from the fruiting bodies of Ganoderma lucidum and their inhibitory effects on adipocyte differentiation in 3T3-L1 Cells.

Author

Lee I, Seo J, Kim J, Kim H, Youn U, Lee J, Jung H, Na M, Hattori M, Min B, and Bae K

Subjects
3T3-L1 Cells, Adipocytes drug effects, Animals, Fruiting Bodies, Fungal chemistry, Japan, Lanosterol chemistry, Mice, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Triterpenes chemistry, Adipocytes metabolism, Lanosterol analogs & derivatives, Lanosterol isolation & purification, Lanosterol pharmacology, Reishi chemistry, Triterpenes isolation & purification, Triterpenes pharmacology
Abstract

Four new lanostane triterpenes, butyl ganoderate A (1), butyl ganoderate B (2), butyl lucidenate N (3), and butyl lucidenate A (4), were isolated from the fruiting bodies of Ganoderma lucidum together with 14 known compounds (5-18). The structures of the new triterpenes were established by extensive spectroscopic studies and chemical evidence. In addition, the inhibitory effect of isolated compounds on adipocyte differentiation in 3T3-L1 cells was examined.

Published
2010
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