1. The relationship of renal function to segmental vascular stiffness, ankle-brachial index, and peripheral artery disease.
- Author
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Lin YH, Sung KT, Tsai CT, Wu PC, Lai YH, Lo CI, Yu FC, Wu HP, Lan WR, Kuo JY, Hou CJ, Yen CH, Peng MC, Hung TC, Hung CL, Lai E, and Yeh HI
- Subjects
- Aged, Aged, 80 and over, Female, Glomerular Filtration Rate, Humans, Japan, Male, Middle Aged, Renal Insufficiency physiopathology, Vascular Stiffness, Ankle Brachial Index instrumentation, Peripheral Arterial Disease epidemiology, Pulse Wave Analysis instrumentation, Renal Insufficiency diagnosis
- Abstract
The authors consecutively assessed various arterial pulse-wave velocity (PWV) indices and ankle-brachial index (ABI) by an automatic device (VP2000, OMRON Health Care Co. Ltd., Kyota, Japan) in outpatients with ≥ 1 cardiovascular risk. PAD was defined as ABI ≤ 0.9. Among 2309 outpatients (mean age 62.4 years), worse renal function was associated with higher brachial-ankle PWV, heart-carotid PWV, heart-femoral PWV (hf-PWV), and lower ABI (all P < .001). Multivariate regression models showed independent associations between lower eGFR, lower ABI (Coef: 0.42 & 0.41 for right and left), higher hf-PWV (Coef: -11.4 [95% CI: -15.4, -7.3]) and greater PAD risk (adjusted OR: 0.83 [95% CI: 0.76, 0.91], all P < .05). eGFR set at 77 mL/min/1.73m
2 was observed to be useful clinical cutoff (c-statistics: 0.67) for identifying PAD (P for ΔAUROC: .009; likelihood X2 : 93.82 to 137.43, P < .001) when superimposed on clinical risks. This study suggested early renal insufficiency is tightly linked to region-specific vascular stiffness and PAD., (©2018 Wiley Periodicals, Inc.)- Published
- 2018
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