1. Streptocinnamides A and B, Depsipeptides from Streptomyces sp. KMM 9044.
- Author
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Makarieva TN, Romanenko LA, Mineev KS, Shubina LK, Guglya EB, Kalinovskaya NI, Ivanchina NV, Guzii AG, Belozerova OA, Kovalchuk SI, Popov RS, Denisenko VA, Mikhailov VV, Babenko VV, Ilina EN, Malakhova MV, Terekhov SS, Kudzhaev AM, Dmitrenok PS, Yampolsky IV, and Stonik VA
- Subjects
- Anti-Bacterial Agents pharmacology, Geologic Sediments microbiology, Japan, Phylogeny, Depsipeptides chemistry, Streptomyces chemistry
- Abstract
The bacterium Streptomyces sp. KMM 9044 from a sample of marine sediment collected in the northwestern part of the Sea of Japan produces highly chlorinated depsiheptapeptides streptocinnamides A ( 1 ) and B ( 2 ), representatives of a new structural group of antibiotics. The structures of 1 and 2 were determined using nuclear magnetic resonance and mass spectrometry studies and confirmed by a series of chemical transformations. Streptocinnamide A potently inhibits Micrococcus sp. KMM 1467, Arthrobacter sp. ATCC 21022, and Mycobacterium smegmatis MC2 155.
- Published
- 2022
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