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This study analyses the instruction and organisation of the measurement domain by comparing textbooks from China, Japan, and Malaysia. Focusing on length measurement, we adopted the use of "praxeology" from the Anthropological Theory of the Didactics as a framework to reveal the knowledge to be taught in the transposition process, and "developmental progression of levels of thinking" from Learning Trajectories as a framework to reveal the mental processes or actions generated to achieve the learning goals from the domain. The findings are assembled in three dimensions: types of tasks, accumulation of practice blocks per thinking levels, and instruction sequences. The results indicate that all three countries promote, in different degrees according to their education goals, the development of measurement knowledge by: understanding how to use measurement tools, coordinating the relationship between standard units, and estimating measurements. Lastly, the theoretical framework is proposed as a tool to justify instructional decisions.

This paper deals with the nature of teaching mathematical thinking and presents a case study of a single Japanese lesson where the characteristics of mathematical thinking and the teaching thereof are identified in relation to multiplication. The raison d'être for this teaching is questioned and investigated by looking at how multiplication is described in the curriculum and representative textbook material. It is seen how Japanese teachers are institutionally conditioned to incorporate mathematical thinking in the context of multiplication, something which may appear in contrast to other countries. The lesson is analysed using the notion of praxeologies and didactic co-determination conceptualised in the Anthropological Theory of the Didactic.

In this article, the conceptions of variability held by samples of Japanese and Thai senior high school mathematics teachers were identified, based on the framework proposed by Shaughnessy (2007), using a comparative survey study. From contrasting the results of the two groups, relative tendencies of insufficient statistical knowledge for variability were found in both samples, such as a tendency of Japanese teachers to overgeneralize equiprobability, whereas Thai teachers tended to overgeneralize estimation. Based on these findings, the use of well-known tasks from the research literature for this comparative study seems useful to clarify the relative tendencies and insufficiencies in teacher knowledge and conceptions regarding variability held by both groups.

Alemtuzumab is used with reduced-toxicity conditioning (RTC) in allogeneic hematopoietic cell transplantation (HCT), demonstrating efficacy and feasibility for patients with inborn errors of immunity (IEI) in Western countries; however, the clinical experience in Asian patients with IEI is limited. We retrospectively analyzed patients with IEI who underwent the first allogeneic HCT with alemtuzumab combined with RTC regimens in Japan. A total of 19 patients were included and followed up for a median of 18 months. The donors were haploidentical parents (n = 10), matched siblings (n = 2), and unrelated bone marrow donors (n = 7). Most patients received RTC regimens containing fludarabine and busulfan and were treated with 0.8 mg/kg alemtuzumab with intermediate timing. Eighteen patients survived and achieved stable engraftment, and no grade 3–4 acute graft-versus-host disease was observed. Viral infections were observed in 11 patients (58%) and 6 of them presented symptomatic. The median CD4+ T cell count was low at 6 months (241/µL) but improved at 1 year (577/µL) after HCT. Whole blood cells continued to exhibit > 80% donor type in most cases; however, 3/10 patients exhibited poor donor chimerism only among T cells and also showed undetectable levels of T-cell receptor recombination excision circles (TRECs) at 1 year post-HCT. This study demonstrated the efficacy and safety of alemtuzumab; however, patients frequently developed viral infections and slow reconstitution or low donor chimerism in T cells, emphasizing the importance of monitoring viral status and T-cell-specific chimerism. (238 < 250 words) [ABSTRACT FROM AUTHOR]

This article presents preliminary results from a survey commissioned for ICME 13 (2016) focusing on "Teachers Working and Learning Through Collaboration". It takes as a starting point a previous survey, commissioned for ICME 10 in 2004 that focused on Mathematics Teacher Education. The current survey focuses centrally on teachers involved in collaborations, sometimes in formal settings of professional development, but also in a more diverse range of collaborative settings including research initiatives. The roles of teachers involved in the collaboration, survey methods, decisions and limitations are described. While some of the findings to date resonate with those of the earlier survey, other findings highlight characteristics and issues relating to the differing ways in which teachers collaborate, either with other teachers or the various "others", most notably mathematics teacher educator researchers. The roles and relationships that contribute to learning in such collaborations, as well as theories and methodologies found in survey sources, are a focus of the findings presented here. Studies rarely theorised collaboration, and few of those that did so reported explicitly on how their theoretical frame shaped the design of research methodologies/ approaches guiding activities with teachers. One significant outcome has been the difficulty of relating teachers' learning to collaboration within a project, although many initiatives report developments in teaching, teacher learning and students' learning.

Background: The amyloid-β1-42 (Aβ42) level is a biomarker that is widely used to evaluate individual cognitive dysfunction early in neurodegenerative diseases, as well as differentiate between normal cognitive function, mild cognitive impairment, Alzheimer's disease, and vascular cognitive impairment. Objective: Our cross-sectional study evaluated the association between daily exercise and physical and cognitive function and Aβ42 levels among a subsample of 325 older adults from the Kasama Study. Methods: Participants (age: 74.5 [range 65–90] years) were classified into three exercise groups: the dual-task (DEG, n = 128), single-task (SEG, n = 122), and non-exercise (NEG, n = 75) groups. The main outcomes were the plasma Aβ42 levels and the scores of the five cognitive (5-COG) tests and five cognition-related physical function (5-PHYS) tests. Results: The Aβ42 levels and 5-COG and 5-PHYS scores were higher in the SEG and DEG than in the NEG. The Aβ42 levels were higher in the DEG than in the NEG (p = 0.008). Conclusions: Physical activities such as regular exercise may benefit older adults, improving their cognitive and physical function. [ABSTRACT FROM AUTHOR]

This study analyses the instruction and organisation of the measurement domain by comparing textbooks from China, Japan, and Malaysia. Focusing on length measurement, we adopted the use of praxeology from the Anthropological Theory of the Didactics as a framework to reveal the knowledge to be taught in the transposition process, and developmental progression of levels of thinking from Learning Trajectories as a framework to reveal the mental processes or actions generated to achieve the learning goals from the domain. The findings are assembled in three dimensions: types of tasks, accumulation of practice blocks per thinking levels, and instruction sequences. The results indicate that all three countries promote, in different degrees according to their education goals, the development of measurement knowledge by: understanding how to use measurement tools, coordinating the relationship between standard units, and estimating measurements. Lastly, the theoretical framework is proposed as a tool to justify instructional decisions. [ABSTRACT FROM AUTHOR]

After 26 years of absence in Japan, a classical swine fever (CSF) outbreak occurred at a domestic pig farm in 2018. Vaccination against the CSF virus with a live attenuated vaccine at pig farms was restarted in October 2019, which was 13 years after the 2006 ban on vaccination. An individual-based simulation model for CSF antibody dynamics was developed to determine an effective CSF vaccination strategy for pig populations. In creating a simulated pig herd, the optimal vaccination age of piglets and the effect of vaccinating piglets twice were evaluated. Additionally, the herd immunity was monitored every 6 months for 4 years after the start of vaccination, and the effects of intensive sow replacement policies were assessed. The simulation results indicated that the vaccination age should be delayed relative to the age used before the 2006 ban on vaccination and shifted earlier, from 8 weeks to 6 weeks, as time elapses. The simulations indicated a tradeoff in protection between the weaning period (i.e., maternally derived antibodies) and the fattening period (i.e., by vaccine-induced antibodies). Mixing sows with high and low antibody titers, particularly sows that received the first vaccination and those born after the start of vaccination, resulted in a high variation in antibody titer among pigs on the farm. This study also clarified the positive effect of intensive sow replacement strategies on shortening the period in which sows show diverse titers. Differences in sow replacement rates among farms and/or the time lag in starting vaccination in different prefectures result in heterogeneity in herd immunity in Japan; thus, herd immunity status should be examined at every farm using this simulation model. [ABSTRACT FROM AUTHOR]

The Aira caldera, located in southern Kyushu, Japan, originally formed 100 ka, and its current shape reflects the more recent 30 ka caldera-forming eruptions (hereafter, called the AT eruptions). This study aimed to delineate the detailed two-dimensional (2D) seismic velocity structure of the Aira caldera down to approximately 15 km, by means of the travel-time tomography analysis of the seismic profile across the caldera acquired in 2017 and 2018. A substantial structural difference in thickness in the subsurface low-velocity areas in the Aira caldera between the eastern and western sides, suggest that the Aira caldera comprises at least two calderas, identified as the AT and Wakamiko calderas. The most interesting feature of the caldera structure is the existence of a substantial high-velocity zone (HVZ) with a velocity of more than 6.8 km/s at depths of about 6–11 km beneath the central area of the AT caldera. Because no high ratio of P- to S-wave velocity zones in the depth range were detected from the previous three-dimensional velocity model beneath the AT caldera region, we infer that the HVZ is not an active magma reservoir but comprises a solidified and cool remnant. In addition, a poorly resolved low-velocity zone around 15 km in depth suggests the existence of a deep active magma reservoir. By superimposing the distribution of the known pressure sources derived from the observed ground inflation and the volcanic earthquake distribution onto the 2D velocity model, the magma transportation path in the crust was imaged. This image suggested that the HVZ plays an important role in magma transportation in the upper crust. Moreover, we estimated that the AT magma reservoir in the 30 ka Aira caldera-forming eruptions has the total volume of 490 km3 DRE and is distributed in a depth range of 4–11 km. [ABSTRACT FROM AUTHOR]

What is the product of Lesson Study? Lesson Study is a scientific activity for teachers based on the methodology introduced in the 1880s. In Japan, research topics for Lesson Study are usually shared through the regular revisions of the curriculum and the research movement of several societies. As a result of teachers' efforts to overcome challenges on the topics of Lesson Study, several local theories of teaching are shared. The "Problem Solving Approach" has been commonly known as a Japanese teaching approach and a theory of teaching for developing children who learn mathematics by/for themselves. It includes teaching about learning how to learn. Other important products of Lesson Study are theories for curriculum, described in teacher's guidebooks as a number of technical terms which are only used by teachers and mathematics educators for sharing pedagogical content knowledge. (Contains 8 figures and 3 tables.)

The rapid growth of urban populations and the environmental concerns associated with this growth challenge city planners and developers to consider more sustainable building systems. In Japan, the recent change in the law governing building standards and introduction of cross-laminated timber (CLT) offer the prospect of a further extension of the height of timber buildings to the high-rise category. Because of that, many researchers have begun to research the possibility of hybridizing CLT with steel-framed structures to increase the performance of buildings utilizing CLT. This paper presents the test and numerical results of cyclic loading experiments performed upon CLT shear wall infilled hybrid steel frames with concealed metal plates and drift pin (DP) connections. For the failure modes of the tests, shear failure of CLT at around 1/50–1/30 rad were observed in almost all specimens, except the specimen with slender steel beams, which led the CLT to out-of-plane deformation. The load sharing effect between two components were also evaluated, showing that the steel and CLT infill worked closely together to resist the lateral load. After the experiments, a numerical model was developed using the nonlinear finite analysis software SNAP V7.0 to predict the results of the experiments. The model was developed based on the results of element tests conducted previously, was validated using the test results, and can potentially serve as the basis for an appropriate form of methodology with which to design future CLT-steel hybrid structures for service in seismically active regions. [ABSTRACT FROM AUTHOR]

In the winter of 2010-2011, Japan experienced a large outbreak of infections caused by clade 2.3.2.1 H5N1 high pathogenicity avian influenza viruses (HPAIVs) in wild birds. Interestingly, many tufted ducks (Aythya fuligula), which are migratory diving ducks, succumbed to the infection, whereas only one infection case was reported in migratory dabbling duck species, the major natural hosts of the influenza A virus, during the outbreak. To assess whether the susceptibility of each duck species to HPAIVs was correlated with the number of cases, tufted duck and dabbling duck species (Eurasian wigeon, Mareca penelope; mallard, Anas platyrhynchos; Northern pintail, Anas acuta) were intranasally inoculated with A/Mandarin duck/Miyazaki/22M807-1/2011 (H5N1), an index clade 2.3.2.1 virus previously used for experimental infection studies in various bird species. All ducks observed for 10 days post-inoculation (dpi) mostly shed the virus via the oral route and survived. The tufted ducks shed a higher titer of the virus than the other dabbling duck species, and one of them showed apparent neurological symptoms after 7 dpi, which were accompanied by eye lesions. No clinical symptoms were observed in the dabbling ducks, although systemic infection and viremia were observed in some of them sacrificed at 3 dpi. These results suggest that the susceptibility of clade 2.3.2.1 HPAIVs might differ by duck species. [ABSTRACT FROM AUTHOR]

In the fall of 2022, high pathogenicity avian influenza viruses (HPAIVs) were detected from raptors and geese in Japan, a month earlier than in past years, indicating a shift in detection patterns. In this study, we conducted a phylogenetic analysis on H5N1 HPAIVs detected from six wild birds during the 2022/2023 season to determine their genetic origins. Our findings revealed that these HPAIVs belong to the G2 group within clade 2.3.4.4b, with all isolates classified into three subgroups: G2b, G2d, and G2c. The genetic background of the G2b virus (a peregrine falcon-derived strain) and G2d viruses (two raptors and two geese-derived strains) were the same as those detected in Japan in the 2021/2022 season. Since no HPAI cases were reported in Japan during the summer of 2022, it is probable that migratory birds reintroduced the G2b and G2d viruses. Conversely, the G2c virus (a raptor-derived strain) was first recognized in Japan in the fall of 2022. This strain might share a common ancestor with HPAIVs from Asia and West Siberia observed in the 2021/2022 season. The early migration of waterfowl to Japan in the fall of 2022 could have facilitated the early invasion of HPAIVs. [ABSTRACT FROM AUTHOR]

Understanding the seismic resistance mechanisms and safety limits of cross-laminated timber (CLT) buildings and performing an accurate evaluation of their seismic performance is critical in earthquake-prone areas such as Japan, the US, and Italy to ensure that human lives are protected against major earthquakes. However, the knowledge from shaking table tests of full-scale CLT buildings is limited, and most tests' maximum interstory drift is less than 4%. As a first step toward collapse analysis, this study replicated a full-scale two-story shake table experiment with a maximum interstory drift of 8.77%. The analysis software was developed by the authors and modified to consider the restoring force and the P–δ effect to replicate seismic behavior at large deformation. The skeleton curve parameters were employed in the analysis model and then changed. The results that matched the experimental results well were searched comprehensively by performing data assimilation. As a result, both the overall behavior (story shear force–interstory drift relationship) and the detailed behavior (uplift displacement of CLT wall foot of the first story) were consistent with the experimental results, indicating that the proposed analytical method can replicate the seismic behavior of CLT buildings even at large deformation. [ABSTRACT FROM AUTHOR]

There is increasing interest in using cross-laminated timber (CLT) in buildings because of its high strength and stiffness. In Japan, structural design guidelines for CLT buildings were established in 2016 and construction of mid-rise buildings is increasing. Wide-panel walls can exceed widths of 10 m and integrate cut-outs for window and door openings. However, under lateral loads, corner cracks at the openings have been the most prevalent failure mechanism. To investigate the initiation and propagation of corner cracks, a series of bendings are undertaken on L- and T-shape specimens extracted from the CLT panels. In addition, three-point bending and shear tests are also carried out on beam sections extracted from the CLT panels. Three types of brittle failure were observed: bending failure of the beam or column, and rolling shear failure. [ABSTRACT FROM AUTHOR]

Compared Japanese and U.S. geometry curricula using the van Hiele model, U.S. National Council of Teachers of Mathematics Standards, and Japanese Course of Study by Mombusho, examining how the students regarded van Hiele levels and determining differences in geometry instruction. Japanese curricula and students were ahead of U.S. curricula and students. Similarities and differences existed in instruction. (SM)

In September 2018, classical swine fever (CSF) reemerged in Japan after more than a quarter of a century. After the first notification on a pig farm, wild boars positive for CSF were found continuously in the surrounding area. Gifu was the first prefecture in Japan to disseminate oral vaccines to wild boars in March 2019, with vaccines spread to approximately 14,000 sites between 2019 and 2020. While these diligent measures seemed to have shown some effectiveness, several vaccine spray sites remained without wild boar emergence. Based on the vaccine dissemination records from these periods, this study conducted a statistical analysis to propose more effective vaccine dissemination sites. First, a generalized linear mixed model was used to identify factors correlated with wild boar emergence. Then, two spatial interpolation methods, inverse distance weighted (IDW) and Kriging, were adopted to create a probability map of wild boar emergence for the entire Gifu Prefecture. The analysis showed a positive correlation between wild boar emergence and the appearance of raccoons, raccoon dogs, and crows as well as road density and wild boar distribution index. In particular, raccoon (OR: 1.83, 95%CI: 1.25–2.68, p < 0.001), raccoon dog (OR: 1.81, 95%CI: 1.25–2.66, p < 0.001), and medium level road density (OR: 1.56, 95%CI: 1.04–2.39, p = 0.04) were strongly correlated with wild boar emergence. The spatial interpolation approach resulted in better prediction accuracy for the Kriging method than for IDW by the root mean square error, but both approaches identified a high wild boar appearance probability area in southeastern Gifu and a low appearance probability area in central Gifu. Here we have demonstrated a tool to effectively disperse oral vaccine to wildlife. [ABSTRACT FROM AUTHOR]

Aims: Hypoxia‐inducible factor‐prolyl hydroxylase (HIF‐PH) inhibitors have been developed for the treatment of renal anaemia; however, no study has evaluated the safety and efficacy of HIF‐PH inhibitors in patients with heart failure (HF). This study was designed to evaluate the safety and efficacy of daprodustat, a HIF‐PH inhibitor, in patients with HF and renal anaemia. Methods and results: We designed a pilot, multi‐centre, open‐label, randomized controlled study, in which 50 patients with HF complicated with chronic kidney disease and anaemia will be randomized 1:1 to either the daprodustat or control group at seven sites in Japan. Study entry requires New York Heart Association Class II HF symptoms or a history of hospitalization due to HF, an estimated glomerular filtration rate of <60 mL/min/1.73 m2, and a haemoglobin level of 7.5 to <11.0 g/dl. Patients randomized to the daprodustat group will be treated with oral daprodustat, and the dose will be uptitrated according to the changes in the haemoglobin level from previous visits. In this study, we will evaluate the impact of HIF‐PH inhibitors on cardiac function using advanced cardiovascular imaging modalities, including cardiac magnetic resonance imaging. The primary outcome is the haemoglobin level at 16 weeks of randomization, and all adverse events will be recorded and evaluated for any association with daprodustat treatment. Conclusion: Considering the hypothetical upside and downside of using HIF‐PH inhibitors in anaemic patients with HF and chronic kidney disease, and because there are virtually no safe and effective treatments for patients with anaemia not caused by iron deficiency, our study results will contribute significantly to this field. [ABSTRACT FROM AUTHOR]

Copyright of Economic Botany is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Many high pathogenicity avian influenza (HPAI) cases in wild birds due to H5N1 HPAI virus (HPAIV) infection were reported in northern Japan in the winter of 2021–2022. To investigate the epidemiology of HPAIVs brought to Japan from surrounding areas, a genetic analysis of H5 HPAIVs isolated in northern Japan was performed, and the pathogenicity of the HPAIV in chickens was assessed by experimental infection. Based on the genetic analysis of the hemagglutinin gene, pathogenic viruses detected in northern Japan as well as one in Sakhalin, the eastern part of Russia, were classified into the same subgroup as viruses prevalent in Europe in the same season but distinct from those circulating in Asia in winter 2020–2021. High identities of all eight segment sequences of A/crow/Hokkaido/0103B065/2022 (H5N1) (Crow/Hok), the representative isolates in northern Japan in 2022, to European isolates in the same season could also certify the unlikeliness of causing gene reassortment between H5 HPAIVs and viruses locally circulating in Asia. According to intranasal challenge results in six-week-old chickens, 50% of the chicken-lethal dose of Crow/Hok was calculated as 104.5 times of the 50% egg-infectious dose. These results demonstrated that the currently prevalent H5 HPAIVs could spread widely from certain origins throughout the Eurasian continent, including Europe and the Far East, and implied a possibility that contagious viruses are gathered in lakes in the northern territory via bird migration. Active monitoring of wild birds at the global level is essential to estimate the geographical source and spread dynamics of HPAIVs. [ABSTRACT FROM AUTHOR]

White-tailed sea eagle (Haliaeetus albicilla), a regionally rare species of raptor, is threatened in several countries. To assess the risk of H5 high pathogenicity avian influenza (HPAI) viral infection in rare bird species, we performed experimental infections with a GS/GD96-lineage H5N6 HPAI virus of clade 2.3.4.4e in white-tailed sea eagles. Additionally, during the winter of 2020--2021 in Japan, we accidentally encountered a white-tailed sea eagle that had a fatal outcome due to natural infection with a GS/GD96-lineage H5N8 HPAI virus of clade 2.3.4.4b, allowing us to compare experimental and natural infections in the same rare raptor species. Our experiments demonstrated the susceptibility of white-tailed sea eagles to the GS/GD96-lineage H5 HPAI virus with efficient replication in systemic organs. The potential for the viruses to spread within the white-tailed sea eagle population through indirect transmission was also confirmed. Comprehensive comparisons of both viral distribution and histopathological observations between experimentally and naturally infected white-tailed sea eagles imply that viral replication in the brain is responsible for the disease severity and mortality in this species. These findings provide novel insights into the risk assessment of H5 HPAI viral infection in white-tailed sea eagles, proper diagnostic procedures, potential risks to artificially fed eagle populations and persons handling superficially healthy eagles, potential impact of intragastric infection on eagle outcomes, and possibility of severity of the disease being attributed to viral replication in the brain. [ABSTRACT FROM AUTHOR]

Bovine viral diarrhea virus (BVDV) is a causative agent of bovine viral diarrhea. In Japan, a previous study reported that subgenotype 1b viruses were predominant until 2014. Because there is little information regarding the recent epidemiological status of BVDV circulating in Japan, we performed genetic characterization of 909 BVDV isolates obtained between 2014 and 2020. We found that 657 and 252 isolates were classified as BVDV-1 and BVDV-2, respectively, and that they were further subdivided into 1a (35 isolates, 3.9%), 1b (588, 64.7%), 1c (34, 3.7%), and 2a (252, 27.7%). Phylogenetic analysis using entire E2 coding sequence revealed that a major domestic cluster in Japan among BVDV-1b and 2a viruses were unchanged from a previous study conducted from 2006 to 2014. These results provide updated information concerning the epidemic strain of BVDV in Japan, which would be helpful for appropriate vaccine selection. [ABSTRACT FROM AUTHOR]

Introduction: Dual-task (DT) exercise can act as a substitute, which can help improve both physical and cognitive functions. Thus, this study investigated the effects of a game-like cognitive DT exercise called "Synapsology" (SYNAP) among the oldest residents of a nursing home. Methods: Participants (aged 85-97 years) were assigned to the intervention group (n = 12) and the control group (n = 12). The intervention group underwent 60-minute sessions, twice a week for 24 weeks. Results: A comparison of the Mini-Mental State Examination scores and six physical function tests, before and after the intervention, shows that the SYNAP had a positive impact on the cognitive and physical functions among the intervention group. Discussion: These findings suggest that SYNAP may help maintain or improve cognitive and physical functions among older adults compared to no interventions. Therefore, SYNAP would act as a beneficial tool amidst a "superaging" society like Japan. [ABSTRACT FROM AUTHOR]

To promote the development of cross-laminated timber (CLT) structures, the Japanese Government Notifications on Structural Design of CLT Buildings (GN 611) was issued in 2016. In GN 611, three types of platform-framing CLT structures were classified in the simple calculation method of Route-1. Compared with a platform-framing structure, which has been clarified in GN 611, a balloon-framing structure is superior in shortening the construction period and reducing the number of CLT panels and metal connectors. To study the seismic properties of balloon-framing CLT structures and develop new structures for a CLT building, four full-scale, 3-story CLT structures were tested under quasi-static cyclic loading: Specimen 1 was a platform-framing structure with narrow wall panels; Specimen 2 was a balloon-framing structure with continuous wall panels; Specimen 3 a was platform-framing structure with wide wall panels; and Specimen 4 was a balloon-framing structure with continuous wall panels and glulam beams. In this study, experiments were conducted, and the seismic performance of the balloon- and platform-framing CLT structures were evaluated and compared. The test results indicated that the seismic properties of Specimens 1, 2, and 3 were similar and that the design method of Specimen 1, as specified in GN 611, was applicable for Specimens 2 and 3. Specimen 4 exhibited higher lateral load resistance than the other three specimens. The performance of Specimen 4 depended on the moment-resisting performance of the glulam beam and CLT wall joint. In this case, the moment-resisting performance obtained through the experiment was significantly higher than the predicted performance. [ABSTRACT FROM AUTHOR]

The clinical and virologic features of hepatitis E virus (HEV) infection seem to vary among regions even in developed countries. However, we have little information on the diversity of HEV infection. Here, we investigated the characteristics of 26 patients in our hospital located in Tochigi prefecture, 90 km north of Tokyo, between 2000 and 2019. The reported number of patients with acute hepatitis E is increasing in Japan because measurement of IgA‐class anti‐HEV antibody was commercially available from 2011. In contrast, the numbers at our hospital were 1.5/y and 1.0/y in 2000 to 2011 and 2012 to 2019, respectively. This is attributed to the fact that we have been investigating HEV as a cause of unknown hepatitis before 2011. Among isolated HEV subgenotypes, including 3a, 3b, 4b, 4c, and 4d, all three patients with subgenotype 4c infection presented acute liver failure. Four HEV strains shared more than or equal to 99% identity within the 412‐nucleotide partial sequence, in which the time and place of HEV infection varied, except for one intrafamilial infection. In addition, some strains were similar to HEV strains isolated far from Tochigi prefecture. In conclusion, the number of patients with acute hepatitis E was not increasing at Jichi Medical University Hospital and some strains were found to circulate in Japan. Highlights: The numbers of patients with acute hepatitis E was not increasing at Jichi Medical University Hospital located in Tochigi prefecture, 90 km north of Tokyo.Among 5 subgenotypes noted in the present study, all 3 patients with subgenotype 4c infection presented acute liver failure.Several strains were similar to HEV strains isolated far from Tochigi prefectureHEV‐contaminated foods are likely to circulate around Japan. [ABSTRACT FROM AUTHOR]

Copyright of Paradigma is the property of Universidad Pedagogica Experimental Libertador and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The spread of African swine fever (ASF) has reached pandemic levels over the last decade, and outbreaks of this disease in China, Mongolia, Vietnam and Cambodia in 2018 and 2019 could accelerate its transmission to neighbouring Asian territories. Thus, the risk that the ASF virus (ASFV) will be introduced to disease‐free territories increases each year. Since Japan is an island nation, the most likely way in which ASFV would be introduced is via pork products brought in air passengers' luggage (PPAP). Therefore, in the present study, we assessed the risk of ASFV introduction to Japan via PPAP. For the purposes of this analysis, we considered 214 international commercial flights travelling from 47 origin territories to 31 destination airports as potential routes of ASFV introduction via PPAP. The risk was estimated quantitatively through a stochastic model that considered the volume of air passengers' luggage, the amount of confiscated pork products that were carried in air passengers' luggage and the disease status of the origin territory. The overall mean annual probability of ASFV introduction to Japan via PPAP was found to be 0.941 [95% confidence interval (CI), 0.661–1.000], which approximately corresponds to one introduction every 1.06 years. At the origin territory level, Mongolia was led as the highest risk territory, with a risk of 0.864 (95% CI, 0.434–1.000), followed by China (0.697; 0.223–0.999), Vietnam (0.662; 0.196–0.998) and the Russian Federation (0.136; 0.018–0.401). At the destination airport level, Narita International Airport had the highest risk (0.905; 0.537–1.000), followed by Kansai International Airport (0.496; 0.109–0.961), Tokyo International Airport (0.389; 0.072–0.879) and Chubu Centrair International Airport (0.338; 0.058–0.816). This information will help improve risk management activities and monitoring systems to prevent the introduction of ASFV to Japan. [ABSTRACT FROM AUTHOR]

Bovine viral diarrhea virus (BVDV) footprint has spread across the globe and is responsible for one of the most economically important diseases in cattle. In Japan, some regional surveillance and preventive measures to control bovine viral diarrhea (BVD) have been implemented. However, BVDV infection is poorly understood in cattle industries, and there is no systematic BVD surveillance system and control program. Kyushu is the center for raising beef cattle in Japan. Therefore, this study aimed to determine the BVDV infection using a slaughterhouse survey among beef cattle in Kyushu, Japan. A total of 1,075 blood samples were collected at two regional slaughterhouses in Miyazaki prefecture from December 2015 to June 2016. Antigen ELISA was used for detection of BVDV antigen in blood samples. Two samples showed positive results (2/1,075; 0.18%). BVDV RNA was extracted from positive blood samples; the sequence was determined and analyzed by the neighbor-joining method for construction of the phylogenetic tree. Phylogenetic analysis based on the 5’-UTR revealed that the two positive samples were grouped into the same subtype BVDV-1b in the BVDV-1 genotype, but the infected cattle belonged to two different farms. In conclusion, this is the first study to identify the presence of BVDV in a slaughterhouse survey in Kyushu. These findings suggest that a slaughterhouse survey is a useful tool for developing a surveillance system for monitoring infectious diseases in cattle. [ABSTRACT FROM AUTHOR]

Ticks are blood-sucking ectoparasites that transmit zoonotic pathogens to humans and animals. Ticks harbor not only pathogenic microorganisms but also endosymbionts. Although some tick endosymbionts are known to be essential for the survival of ticks, their roles in ticks remain poorly understood. The main aim of this study was to isolate and characterize tick-borne microorganisms from field-collected ticks using two arthropod cell lines derived from Ixodes scapularis embryos (ISE6) and Aedes albopictus larvae (C6/36). A total of 170 tick homogenates originating from 15 different tick species collected in Japan were inoculated into each cell line. Bacterial growth was confirmed by PCR amplification of 16S ribosomal DNA (rDNA) of eubacteria. During the 8-week observation period, bacterial isolation was confirmed in 14 and 4 samples using ISE6 and C6/36 cells, respectively. The sequencing analysis of the 16S rDNA PCR products indicated that they were previously known tick-borne pathogens/endosymbionts in three different genera: Rickettsia, Rickettsiella, and Spiroplasma. These included four previously validated rickettsial species namely Rickettsia asiatica (n = 2), Rickettsia helvetica (n = 3), Rickettsia monacensis (n = 2), and Rickettsia tamurae (n = 3) and one uncharacterized genotype Rickettsia sp. LON (n = 2). Four isolates of Spiroplasma had the highest similarity with previously reported Spiroplasma isolates: Spiroplasma ixodetis obtained from ticks in North America and Spiroplasma sp. Bratislava 1 obtained from Ixodes ricinus in Europe, while two isolates of Rickettsiella showed 100% identity with Rickettsiella sp. detected from Ixodes uriae at Grimsey Island in Iceland. To the best of our knowledge, this is the first report on successful isolation of Rickettsiella from ticks. The isolates obtained in this study can be further analyzed to evaluate their pathogenic potential in animals and their roles as symbionts in ticks. [ABSTRACT FROM AUTHOR]

Aim: The major transmission mode of hepatitis A virus (HAV) in Japan is the fecal–oral route by contaminated foods. In contrast, HAV infection is well documented as a sexually transmitted disease in Europe and North America. The present study was undertaken to determine the full‐genome sequence of HAV and trace the transmission route of HAV in Japanese men who have sex with men (MSM). Methods: In 2018, we encountered three Japanese MSM with acute hepatitis A co‐infected with HIV for 4–12 years. Serum samples obtained from these patients were used for HAV full‐genome analyses. Results: Isolated HAV strains were segregated into subgenotype IA. The three HAV strains shared 100% identity within the 481‐nucleotide partial sequence. The entire nucleotide sequence showed that the three strains were 99.97% similar to each other with only two nucleotide substitutions. At the amino acid level, the three strains differed from each other by only one or two amino acids. All three strains obtained in the present study were >99.6% identical to the 66 reported strains isolated from Taiwan and European countries during 2015–2017. In addition, these 66 strains include the RIVM‐HAV16‐090 (EuroPride) strain, which has been involved in HAV outbreaks among MSM worldwide. Conclusions: We determined for the first time the full‐genome sequence of HAV isolated from Japanese MSM with acute hepatitis A and found that the strains were identical to those from MSM worldwide. Thus, these HAV strains were imported to Japan from foreign countries through MSM. [ABSTRACT FROM AUTHOR]

Bovine viral diarrhea (BVD) is a chronic disease of cattle caused by infection with BVD virus (BVDV) and can result in economic losses within the livestock industry. In Japan, the test and culling policy is a basic control measure, and implementation of an adequate vaccination program is recommended as a national policy. In addition, optional control measures, including compulsory testing of introduced animals and bulk tank milk (BTM) testing as a mass screening method, are used in several provinces, but their efficacy has not been completely assessed. We evaluated these control measures using the scenario tree model of BVD in Japan, developed in the previous study. The model outputs indicated that compulsory testing of all introduced cattle, rather than only heifers and/or non-vaccinated cattle, was cost effective and reduced the risk of BVDV introduction due to animal movement and that BTM testing could effectively monitor most part of the cattle population. Vaccination coverage and BVDV prevalence among introduced cattle could also affect the cost effectiveness of compulsory testing of targeted cattle, particularly under low vaccination coverage or high BVDV prevalence. However, even with the implementation of a highly effective monitoring scheme for many years, BVD risk could not be eliminated; it instead converged at a very low level (0.02%). Disease models with a cost-effective output could be a powerful tool in developing a control scheme for chronic animal diseases, including BVD, with the consent of relevant stakeholders. [ABSTRACT FROM AUTHOR]

Although population-based cancer registries have reported lower incidence of Waldenstrӧm macroglobulinemia (WM) in East Asia than in Western countries, previous retrospective analyses have found the clinical features of WM to be similar in these two populations. To clarify the characteristics of Japanese WM patients, we retrospectively analyzed clinical and laboratory characteristics, treatments, outcomes, and prognostic factors in 93 patients with WM. Based on the Second International Workshop on WM (IWWM-2) criteria, symptomatic WM was found in 73 (78.5%) and asymptomatic WM in 20 (21.5%) of cases examined. The median overall survival (OS) was similar to that in reports from Western countries. Patients receiving treatment regimens including rituximab exhibited significantly better survival than those not given rituximab. Although prognostic factors for WM in Western countries may not apply to Japanese patients, our finding that newly diagnosed WM patients with pleural effusion have a poorer prognosis suggests that this may be a novel predictor of adverse prognosis in symptomatic WM. [ABSTRACT FROM AUTHOR]

In Japan, hepatitis B or C virus infection has been a major health issue. For the prevention of liver-related deaths, multifaceted strategies have been taken against hepatitis virus. In fiscal year (FY) 2002, nationwide screening for hepatitis was started as a part of health examinations provided by municipal governments. From FY2007, the hepatitis treatment network has been strengthened by the nationwide establishment of regional government-based hepatitis treatment systems, comprising linked regional core centers, specialized institutions for hepatitis treatment, primary care physicians, and regional governments. Special subsidy program for patients with viral hepatitis was started at FY2008. The range of coverage has been expanding from patients treated with interferon to those on nucleotide analogs or interferon-free therapies, including drug prices and examination expenses. The Basic Act on Hepatitis Measures was established in 2009. The Basic Guidelines for Promotion of Control Measures for hepatitis was issued in 2011, comprising nine principles in order to promote measures for hepatitis B and C. The Hepatitis Information Center was established in 2008. Its mission is to provide up-to-date hepatitis-related information, supporting collaboration between regional core centers, and training medical personnel. The revision of the above-mentioned Basic Guidelines in 2016 set the target as the reduction of patients progressing to cirrhosis and/or liver cancer. Achieving this goal definitely requires active collaboration among the national and local governments, regional core centers, and the Hepatitis Information Center, and participation by medical personnel, patients, and people with awareness. [ABSTRACT FROM AUTHOR]

There are some reports regarding hepatitis B virus (HBV) reactivation in patients with myeloma who are HBV carriers or who have had a resolved HBV infection, and there is no standard prophylaxis strategy for these patients. We performed a retrospective multicenter study to determine the incidence and characteristics of HBV reactivation in patients with multiple myeloma. We identified 641 patients with multiple myeloma who had been treated using novel agents and/or autologous stem cell transplantation with high-dose chemotherapy between January 2006 and June 2014 at nine Japanese hospitals. The patients' characteristics, laboratory data, and clinical courses were retrieved and statistically analyzed. During a median follow-up of 101 weeks, one of eight (12.5 %) HBV carriers developed hepatitis and 9 of 99 (9.1 %) patients with resolved HBV infection experienced HBV reactivation; the cumulative incidences of HBV reactivation at 2 years (104 weeks) and 5 years (260 weeks) were 8 and 14 %, respectively. The nine cases of reactivation after resolved HBV infection had received entecavir as preemptive therapy or were carefully observed by monitoring their HBV DNA levels, and none of these cases developed hepatitis. Among patients with multiple myeloma, HBV reactivation was not rare. Therefore, long-term monitoring of HBV DNA levels is needed to prevent hepatitis that is related to HBV reactivation in these patients. [ABSTRACT FROM AUTHOR]

Recent studies pointed out that allergic diseases have increased during the Asian dust storm event (ADSE) in Japan. Daily observations and the atmospheric concentrations of yellow sand (YS) aerosol have been increasing. In this study, YS samples collected from three sites of Japan during ADSE in 2009–2010 were used. The particles were analyzed by X-ray photoelectron spectroscopy (XPS) and X-ray fluorescence—energy dispersive spectrometer (XRF-EDS). We investigate ability of YS extract on enhancing the chemical mediator release and cytokine production from rat basophilic leukemia (RBL-2H3) cells. The dust particles at Fukuoka and Tsukuba were abundant in aluminum (Al), iron (Fe), potassium (K) and titan (Ti) than those at Naha. Concentration of the trace endotoxin and Cryptomeria japonica pollen allergen (Cry j 1) were measured in YS extract. After exposure of RBL-2H3 cells to YS extract, the β-hexosaminidase (β-hex) release, tumor necrosis factor-alpha (TNF-α) production were enhanced in RBL-2H3 cells. This process depends on endotoxin, Cry j 1 and other allergen present in the YS extract. YS water extract also show a strong cytotoxic effect on the cells. This data suggest that low levels of endotoxin and Cry j 1 in YS may cause allergy during the ADSE. [Copyright &y& Elsevier]

The genetic differentiation inherent in Zelkova serrata in Japan and the southern portion of the Korean Peninsula was examined by comparing a chloroplast DNA (cpDNA) sequence over a 16 k baselength in 40 individual samples collected from an area covering the natural distribution range of Z. serrata in Japan and the southern portion of the Korean Peninsula. We detected over 50 single-nucleotide polymorphisms in the protein-coding and intergenic regions, and over 30 insertions/deletions in the intergenic region. From the polymorphisms detected in the cpDNA, 14 haplotypes were identified. These 14 haplotypes had cluster-like structures and genetic differentiation between the clusters was large. Closely related haplotypes existed in adjacent regions. One haplotype existed in both Japan and the Korean Peninsula. By comparison with other Zelkova species, Z. serrata is apparently distinct from European and East Asian Zelkova species and Z. serrata is closest to the Ulmus species in the genus Zelkova. The effects of the analyzed length of the cpDNA sequence on the detection of polymorphisms were analyzed by re-sampling simulation. [ABSTRACT FROM AUTHOR]

In the summer of 2009, a full-scale midrise wood-frame building was tested under a series of simulated earthquakes on the world's largest shake table in Miki City, Japan. The objective of this series of tests was to validate a performance-based seismic design approach by qualitatively and quantitatively examining the building's seismic performance in terms of response kinematics and observed damage. This paper presents the results of detailed damage inspections following each test in a series of five shake table tests, and explains their qualitative synthesis to provide design method validation. The seismic test program had two phases. Phase I was the testing of a seven-story mixed-use building with the first story consisting of a steel special moment frame (SMF) and stories 2-7 made of light-frame wood. In Phase II, the SMF was heavily braced such that it effectively became an extension of the shake table and testing was conducted on only stories 2-7, making the building a six-story light-frame multifamily residential building instead of a mixed-use building. All earthquake motions were scalings of the 1994 Northridge earthquake at the Canoga Park recording station with seismic intensities ranging from peak ground accelerations of 0.22 to 0.88 g. The building performed quite well during all earthquakes with damage only to the gypsum wall board (drywall), no sill plate splitting, no nails withdrawing or pulling through the sheathing, no edge tearing of the sheathing, no visible stud splitting around tie-down rods, and reasonable floor accelerations. On the basis of damage inspection, it was concluded that it is possible to design this type of building and keep the damage to a manageable level during major earthquakes by utilizing the new design approach. [ABSTRACT FROM AUTHOR]

Abstract: Hydrographic observations based on XBT, XCTD, CTD, and ADCP were performed around the eastern mouth of the Tsugaru Strait in June 2003. This study aims to describe the hydrographic structure of the eastern mouth focusing on the subarctic Oyashio water occupying the northern part, and to discuss the intrusion pathway of this water and its modification after the intrusion. Residual and absolute geostrophic velocities show a nearly barotropic inflow (0–25cm/s) and outflow (0–80cm/s) structures in the northern and southern parts of the strait mouth, respectively. In the north, the Oyashio water, classified as the near-bottom and modified Oyashio waters in this study, inflows into the strait. It is inferred that the near-bottom water is changed to the modified Oyashio water after the intrusion by diapycnal mixing and outflow as the modified Oyashio water from underneath of the Tsugaru Warm Current (TWC) water in the deepest part of the strait mouth, together with the TWC water. Horizontal salinity distribution suggests that the near-bottom water is supplied along the isopycnal surface from the subsurface of Hidaka Bay deeper than the strait. [Copyright &y& Elsevier]

A letter to the editor is presented which addresses what the authors refer to as the combined effect of body mass index (BMI) and renal function on long-term clinical outcomes in elderly adults in Japan who underwent percutaneous coronary intervention (PCI) procedures.

The outer shelf of Funka Bay, located at the bay head of Hidaka Bay, is a recognised main winter spawning ground for walleye pollock ( Theragra chalcogramma), whose newly hatched juveniles migrate eastward along the Hidaka shelf to the nursery ground located in the Doto area. To examine the seasonal change of the coastal current along this migration route, four current moorings were deployed along the shelf in Hidaka Bay from April, 2004 to June, 2006. Since these mooring sites were close to the coast, the circulation was estimated after removal of the wind-driven component. It was found that the winter coastal flow, forced by a north-westerly monsoon wind, is clockwise along the Hidaka shelf. However, this flow is weak due to the superimposition of the opposite Coastal Oyashio flow trapped on the shelf. In summer, a bifurcation of the coastal current occurs along the north-eastern Hidaka shelf with a south-eastward flow, associated with the Tsugaru Gyre, and a north-westward flow, consisting of a branch from this gyre. Our results provide a new understanding of the migration of juvenile walleye pollock: (1) very slow transport of juveniles along the Hidaka shelf from winter to spring, and (2) selection of earlier spawning survivors due to the bifurcated flow in early summer. [ABSTRACT FROM AUTHOR]

Abstract: Recent observations of hydrography, currents and volume transports in the straits of the East/Japan Sea are reviewed. It is newly found that bottom cold water in the Korea/Tsushima Strait originating from the northern region of the East/Japan Sea appears not only in summer and autumn but also in winter. Intensive observations in the Korea/Tsushima Strait revealed two distinct cores of northeastward currents in the upper layer of the western and eastern channels. Mean volume transport through the Korea/Tsushima Strait is calculated as 2.5±0.5 Sv from four-year direct and indirect measurements. As continuous monitoring has started in the Tsugaru and Soya Straits, understanding of temporal variability of currents and volume transports through the straits is in progress. For the first time, simultaneous time series of volume transports are available in the Korea/Tsushima and Tsugaru Straits during the winter of 1999–2000. Ouflow through the Tsugaru Strait accounts for about 70% of inflow through the Korea/Tsushima Strait for this period. [Copyright &y& Elsevier]

Abstract: Using long-term sea surface temperature (SST) and acoustic Doppler current profiler (ADCP) data, we examined variations in the current axis of the Tsushima Warm Current (TWC) off the San’in coast of Japan, near the entrance to the Japan Sea. There were large horizontal temperature gradients along the shelf edge in the southwestern Japan Sea from October to May, suggesting that the second branch of the TWC appears not only in spring and autumn but also in winter. From the ADCP data analysis, we found that currents with speeds of approximately 20cms−1 and greater appeared around the shelf edge off San’in coast in all seasons. The SST and ADCP data analyses suggested that the second branch of the TWC exists around the shelf edge off the San’in coast throughout the year. This finding differed from those of previous studies. A relatively strong current (speed greater than 15cms−1) appeared on the shore side in all seasons, except at line W in winter. This current might be the first branch of the TWC. The first branch seemed to occur around in 100m isobaths, but shifted northward and southward because the bottom topography around lines W and M was relatively flat and the shelf was broad. The first branch was very obscure, and it was difficult to define the two branches of the TWC off the San’in coast from the seasonally averaged vectors. However, snapshots of current distribution derived from the ADCP data clearly showed these branches. Hence, both the first and second branches might occur throughout the year off the San’in coast. [Copyright &y& Elsevier]

This paper explores a method for creating large-scale urban 3D models using Historical GIS data. The method is capable of automatically generating realistic VR models based on GIS data at a low cost. 3D models of houses are created from polygon data, fences from line data, and pedestrians and trees from point data. The method is applied to the Virtual Kyoto Project in which the landscape of the whole city of Kyoto of the early Edo era ( ca 17C) is reconstructed. [ABSTRACT FROM AUTHOR]

We report measurements of iron, nutrients, dissolved oxygen, humic-type fluorescence intensity and chlorophyll a concentrations in the coastal waters at the inflow (western) and outflow (eastern) ends of Tsugaru Strait (Japan) in June 2003 and 2004. Two different water masses (intensive eastward flow “subtropical Tsugaru Warm Current Water (TWCw)” and weak westward flow “subarctic Oyashio Water (OW)”) were observed at the eastern end of the strait. TWCw at the southern part of the eastern strait was vertically homogeneous with a uniform concentrations of iron (0.7–1.1 nM for labile dissolved Fe and 14–20 nM for total dissolvable Fe in 2003) as well as other chemical, biological and physical components throughout the water column of 200 m due to strong vertical mixing in the strait. The degree of mixing in the Tsugaru Warm Current (TWC) is predominantly affected by diurnal tidal current, which is strong during the period of tropical tides and weak during the period of equinoctial ones. The especially strong vertical water mixing in 2003 is caused by large dissipation energy input due to the bottom friction of passage-flow through the strait and tidal current. At the northern part of the eastern strait, the fresh surface layer overlying the OW and the deep-bottom waters in 2003 contained large concentrations of dissolved iron, resulting from iron supplied from river runoff and shelf sediments, respectively. These results suggest that the most important mechanism for transporting iron in the strait is the strong vertical water mixing due to the tidal current, and that the iron sources in the coastal waters are the organic-associated, iron-rich freshwater input into the surface water. [ABSTRACT FROM AUTHOR]

Abstract  Hydrographic data and composite current velocity data (ADCP and GEK) were used to examine the seasonal variations of upper-ocean flow in the southern sea area of Hokkaido, which includes the “off-Doto” and “Hidaka Bay” areas separated by Cape Erimo. During the heating season (April–September), the outflow of the Tsugaru Warm Current (TWC) from the Tsugaru Strait first extends north-eastward, and then one branch of TWC turns to the west along the shelf slope after it approaches the Hidaka Shelf. The main flow of TWC evolves continuously, extending eastward as far as the area off Cape Erimo. In the late cooling season (January–March), part of the Oyashio enters Hidaka Bay along the shallower part of the shelf slope through the area off Cape Erimo, replacing almost all of the TWC water, and hence the TWC devolves. It is suggested that the bottom-controlled barotropic flow of the Oyashio, which may be caused by the small density difference between the Oyashio and the TWC waters and the southward migration of main front of TWC, permits the Oyashio water to intrude along the Hidaka shelf slope. [ABSTRACT FROM AUTHOR]

Outbreaks of highly pathogenic avian influenza (HPAI) have been occurring in domestic poultry in Asia since 1996. In the beginning of 2004, HPAI outbreaks were caused by H5N1 virus in two farms and a group of pet chickens in different areas of Japan. In the present study, the pathogenicity of A/chicken/Yamaguchi/7/04 (H5N1), which had been isolated from a dead chicken during the first outbreak in Japan, was assessed in chickens, quails, budgerigars, ducklings, mice, and miniature pigs by experimental infection. The virus was highly pathogenic to all the birds tested. Mice were susceptible to infection with a low mortality rate and miniature pigs were resistant to infection with the virus. [ABSTRACT FROM AUTHOR]

Japanese temperate bass Lateolabrax japonicus juveniles recruit to the surf zone and grow by feeding on commonly occurring coastal copepods. However, little is known about diel and tidal patterns in their migration and feeding habits. We sampled wild juveniles during the neap and spring tides, over periods of 24 h, with small seine nets in the sand flat of the eastern part of Ariake Bay, Kyushu, western Japan. In both the neap and spring tides, abundance of juveniles significantly increased during the daytime, being highest around the time of high tide. The relative gut fullness indices of juveniles drastically increased in the morning (0700–0900) and during the flood tide in the daytime, while major prey copepod (Paracalanus spp.) density in the ambient water was relatively constant. We summarized that L. japonicus juveniles would migrate to the surf zone after sunrise to feed on copepods, and then emigrate from the surf zone after sunset. The migratory behavior of L. japonicus juveniles would be influenced by light (daytime) and feeding activity influenced by both light (morning) and tidal condition (flood tide). The intertidal region of the tidal flat was recognized to be one of the important habitats for L. japonicus during their early life history. [ABSTRACT FROM AUTHOR]

Since there have been practically no surveys of the eggs of Pacific saury ( Cololabis saira) in the western North Pacific (WNP), its spawning ground (SG) distribution has been poorly resolved, based mainly on the larval distribution. This means of estimating SG distribution is imprecise because saury eggs drift for more than a week before they hatch, in a region with intense western boundary currents and their extensions. To improve our understanding of the immature saury, a large number of larvae (body length <25 mm) collected in the WNP during 1993–96 were numerically backtracked to take into account the advection by geostrophic and wind-forced Ekman currents, and the SG locations and ambient sea surface temperatures (SSTs) for the eggs and larvae on the backtracking trajectories were estimated. The resulting seasonal distributions of SGs indicated that both the locations and the intensities of spawning change from season to season. Moreover, the ambient SSTs for eggs just after fertilization ranged from a high of around 21.5°C in early autumn (September to October) to a low of around 15.0°C in late spring (May to June) with an intermediate of around 20.0°C in winter (January to February). The ambient SSTs showed seasonally different gradients while the individuals developed from eggs to early larvae: the SSTs decreased throughout the autumn (September to December), stayed rather constant in winter (January to February), and increased throughout the spring (March to June). The ambient SSTs for the early larvae were at around 19.0°C in autumn and winter (September to February) and around 16.5°C throughout the spring (March to June). [ABSTRACT FROM AUTHOR]

With recent increases in the number of elderly and medically compromised patients, dentists are required to have a more comprehensive understanding of medical problems. There is, however, little awareness of the importance of internal medicine at dental schools in Japan. The aims of the present study were to examine whether dentists need medical knowledge, to examine how often they experience difficulties regarding internal medicine in dental practice, and to determine whether their specialty or career influences their needs or difficulties. A questionnaire based on the above objectives was designed and was sent to all the faculty members in the department of dentistry at Tsurumi University and all dentists who work at the university hospital. Of 408 surveys, 307 (75%) responded. Ninety-nine per cent of respondents recognized the necessity of internal medicine. The dentists specializing in gerodontology, dental anesthesiology or oral and maxillofacial surgery (group S) felt the need of knowledge of internal medicine more frequently than those of other specialties (group O) (Odds ratio 17.5, 95% CI: 2.4 ∼ 129.9; P = 0.000). Seventy-four per cent of the dentists experienced difficulties in day-to-day practice caused by a lack of medical knowledge. Those in group S, experienced difficulties more frequently than those in group O (Odds ratio 5.3, 95% CI: 2.1 ∼ 12.9; P = 0.000). While the more experienced dentists in group S encountered difficulties more often, the more experienced dentists in group O encountered difficulties less often. The need for instruction in internal medicine varies according to dental specialty. Even very experienced dentists might fail to find solutions because of a lack of knowledge of internal medicine. [ABSTRACT FROM AUTHOR]

This study describes transitions over time in the learning strategies used by Japanese seventh-grade students of English as a foreign language (EFL) in relation to the wilt to learn and English achievement. Based on patterns of change, 81 students were categorized by means of statistical cluster analysis, yielding four clusters (groups) with distinct characteristics. One group frequently used a wide array of learning strategies, displayed a strong will to learn, and had high English achievement. Another group was also high in the will to learn and achievement, although frequent use occurred for only selected learning strategies. The other two groups showed lower achievement in English learning. One of these two groups, despite strong willingness and frequent use of strategies, was characterized by inefficient monitoring of learning. The last group had across-the-board, negative change patterns, including decreases in strategy use, the will to learn, and achievement. [ABSTRACT FROM AUTHOR]