Search

The current‐limiting reactor is currently the most used fault current limiting technique to ensure the fault ride‐through of the multi‐terminal dc grid. However, its configuration will significantly prolong the fault current clearance time and increase the dissipated energy of dc circuit breakers. Therefore, this paper proposes a cost‐effective multiline fault current limiter for multiport application in multi‐terminal dc grids, which can effectively limit the rising speed of fault current through the integrated current‐limiting reactors without time delay and significantly reduce their negative impacts on the performance of dc circuit breakers by bypassing the current‐limiting reactors through the solid‐state switch units during the fault current interruption process. The topology and operation process of the multiline fault current limiter are introduced at first. Then, the economic comparison of the proposed device with the existing solutions is presented. Finally, the feasibility and superiorities of the proposed device are verified by extensive simulations and scaled‐down experiments. © 2023 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic has caused an unprecedented worldwide shutdown, and made urban planning reflect on and discuss how to respond to public health crises. Japan’s medical system has been repeatedly rated as the world’s number one by the World Health Organization. This paper analyzes Japan’s diversifed medical facility system, its prevention and control mechanism regarding public health emergencies, and the cultivation of social public awareness, and points out that the Japanese public health crisis response mechanism is characterized by an equal emphasis on the construction of the medical system and the cultivation of public awareness. It is proposed that an effective way to respond to daily medical needs and irregular public health security crises is to improve the community medical quality and grant administrative power to the director of public health centers, promote the “urbanization of people” with public awareness, and improve the resilience of the medical and health system. [ABSTRACT FROM AUTHOR]

Background: Connecting the antegrade wire (AW) and the retrograde wire (RW) is a goal of chronic total occlusion (CTO) treatment, but angiographic guidewire location is sometimes misleading., Aims: The aim of this study was to evaluate the association between intravascular ultrasound (IVUS)-defined AW and RW position and procedural outcomes when treating CTO lesions using the retrograde approach., Methods: Overall, 191 CTO lesions treated using an IVUS-guided retrograde approach at three centres in Japan, China, and the USA were included., Results: When the AW and RW angiographically overlapped, four wire positions were seen on IVUS: (i) AW within the plaque (AW-intraplaque) and RW-intraplaque in 34%; (ii) AW-intraplaque and RW in the subintimal space (RW-subintima) in 28%; (iii) AW-subintima and RW-subintima in 22%; or (iv) AW-subintima and RW-intraplaque in 16%. The procedure succeeded without repositioning the wire in 89% of AW-intraplaque/RW-intraplaque, 61% of AW-intraplaque/RW-subintima and 57% of AW-subintima/RW-subintima, but only one (3%) AW-subintima/RW-intraplaque. Lesion and procedure complexity and failure/complications were greatest in AW-subintima/RW-intraplaque., Conclusions: IVUS-identified vascular compartment concordance versus IVUS-identified vascular compartment mismatch leads to higher success rates irrespective of intraplaque or subintimal passage. AW-subintima/RW-intraplaque was associated with the most complex CTO morphology and procedure, and repositioning the wire was almost always necessary. Visual summary. When the antegrade wire is in the subintimal space and the retrograde wire is in the intraplaque, re-wiring is almost always necessary.

Objective: Systemic lupus erythematosus (SLE), an autoimmune disorder, has been associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain SLE heritability and their putative causal variants are rarely prioritised, which make challenging to elucidate disease biology. To detect new SLE loci and causal variants, we performed the largest genome-wide meta-analysis for SLE in East Asian populations., Methods: We newly genotyped 10 029 SLE cases and 180 167 controls and subsequently meta-analysed them jointly with 3348 SLE cases and 14 826 controls from published studies in East Asians. We further applied a Bayesian statistical approach to localise the putative causal variants for SLE associations., Results: We identified 113 genetic regions including 46 novel loci at genome-wide significance (p<5×10 -8 ). Conditional analysis detected 233 association signals within these loci, which suggest widespread allelic heterogeneity. We detected genome-wide associations at six new missense variants. Bayesian statistical fine-mapping analysis prioritised the putative causal variants to a small set of variants (95% credible set size ≤10) for 28 association signals. We identified 110 putative causal variants with posterior probabilities ≥0.1 for 57 SLE loci, among which we prioritised 10 most likely putative causal variants (posterior probability ≥0.8). Linkage disequilibrium score regression detected genetic correlations for SLE with albumin/globulin ratio (r g =-0.242) and non-albumin protein (r g =0.238)., Conclusion: This study reiterates the power of large-scale genome-wide meta-analysis for novel genetic discovery. These findings shed light on genetic and biological understandings of SLE., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)