1. Possible mechanisms of gastroduodenal mucosal damage in volunteers treated with nonsteroidal antiinflammatory drugs--the usefulness of prodrugs.
- Author
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Yanagawa A, Fukumura T, Matsui H, Uemura H, Endo T, Nakagawa T, and Mizushima Y
- Subjects
- Adult, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Diclofenac adverse effects, Diclofenac therapeutic use, Digestive System blood supply, Digestive System drug effects, Dinoprostone analysis, Double-Blind Method, Duodenal Diseases epidemiology, Duodenal Diseases etiology, Endoscopy, Gastrointestinal, Female, Gastric Mucosa chemistry, Gastric Mucosa pathology, Gastrointestinal Diseases chemically induced, Gastrointestinal Diseases epidemiology, Gastrointestinal Diseases etiology, Hexosamines analysis, Humans, Hydrogen-Ion Concentration, Incidence, Indoleacetic Acids adverse effects, Indoleacetic Acids therapeutic use, Intestinal Mucosa chemistry, Intestinal Mucosa pathology, Japan epidemiology, Male, Microcirculation, Phenylpropionates adverse effects, Phenylpropionates therapeutic use, Prodrugs standards, Regional Blood Flow, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Duodenal Diseases chemically induced, Gastric Mucosa drug effects, Intestinal Mucosa drug effects
- Abstract
A controlled double blind study on the incidence of nonsteroidal antiinflammatory drug (NSAID) gastropathy was performed in 29 healthy volunteers administered diclofenac Na (10 subjects) or a prodrug (loxoprofen Na in 10 subjects and proglumetacin maleate in 9 subjects). The incidence of NSAID gastropathy was significantly lower in the subjects administered the prodrugs than in those administered diclofenac Na (p less than 0.05), which suggested the clinical usefulness of the prodrugs.
- Published
- 1992