1. Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians.
- Author
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Iida A, Takahashi A, Deng M, Zhang Y, Wang J, Atsuta N, Tanaka F, Kamei T, Sano M, Oshima S, Tokuda T, Morita M, Akimoto C, Nakajima M, Kubo M, Kamatani N, Nakano I, Sobue G, Nakamura Y, Fan D, and Ikegawa S
- Subjects
- Alleles, Asian People genetics, China, Gene Frequency, Genetic Association Studies, Genetic Loci, Genetic Predisposition to Disease, Humans, Japan, Odds Ratio, Amyotrophic Lateral Sclerosis genetics, Chromosomes, Human, Pair 19, Chromosomes, Human, Pair 9, Polymorphism, Single Nucleotide
- Abstract
We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians. Both rs12608932 and rs2814707 showed no evidence of association in Japanese and Chinese (rs12608932, combined p = 0.58, odds ratio [OR] = 1.03, 95% confidence interval [CI] 0.93-1.13; rs2814707, combined p = 0.88, OR = 1.10, 95% CI 0.93-1.30). The association of these loci with susceptibility to sporadic ALS is considered negative in East Asians., (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Published
- 2011
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