1. TUMOR MARKERS; Efficacy of CA-125, CEA, AFP, & Beta HCG An institutional based descriptive & prospective study in diagnosis of ovarian malignancy.
- Author
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Shaikh, Naseer Ahmed, Memon, Farzana, and Samo, Rukhsana Parveen
- Subjects
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DIAGNOSTIC use of tumor markers , *OVARIAN tumors , *OVARIAN cancer diagnosis , *ALPHA fetoproteins , *CARCINOEMBRYONIC antigen , *DIAGNOSIS - Abstract
Object: Analysis of serum tumor markers CA-125, CEA, AFP, & β-HCG in patients with ovarian malignant tumors and correlation of their serum levels with histological types. Study Design: Institution based descriptive and prospective study. Place & Duration: Department of Pathology, Liaquat University of Medical & Health Sciences, Jamshoro from January 2009 to June 2011. Material & Methods: One hundred cases, diagnosed as ovarian malignant tumor on H&E staining were selected for study & measurement of serum CA-125, CEA, AFP, & β-HCG preoperatively and postoperatively in each case. Results: Out of 100 ovarian cancers diagnosed on H&E stain 33 were serous cystadenocarcinoma, 29 mucinous adenocarcinoma, 19 germ cell tumors and 15 sex-cord stromal tumors, 1 endometroid carcinoma, 1 brenner tumor, 1 clear cell carcinoma and 1 case of NHL. Increased level of CA-125 was seen preoperatively in 33/33 cases of serous cystadenocarcinoma and 24/29 cases of mucinous adenocarcinoma. Surprisingly increased levels were also seen in 10/19 germ cell tumor and 8/15 in sex-cord stromal tumors. CEA is raised in mucinous tumors. AFP & β-HCG were raised in germ cell tumors & sex cordstromal tumors. Serum tumor marker levels were declined following appropriate therapy of the tumors. Conclusions: Serum tumor markers are useful and important for the detection of ovarian tumors. They may also help in assessment of response to specific treatment, prognosis & follow up of patient. [ABSTRACT FROM AUTHOR]
- Published
- 2014