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Aqualyx (Marllor International Ltd, Rimini, Italy) was originally developed in Italy by Professor Pasquale Motolese and has been commercially available since 2009. It is a deoxycholate, aqueous gelatinous solution mixed with saline and buffering compounds. It is the only drug approved by the European Union for the reduction in localized fat. Aqualyx is sold exclusively to doctors and nurses trained in intralipotherapy. In the case of our patient, the product administered was advertised as Aqualyx, but was not administered by a trained health professional and was administered too superficially. The patient developed severe pain following the injection and was unable to sit for several weeks. There was localized skin necrosis, and palpable collections where the injection was administered. Our initial suspicion was development of an abscess or hematoma. To characterize further, we arranged an ultrasound scan that showed a "superficial hypoechoic lesion" but no deeper infection or spread. The numerous painful nodules ruptured onto the skin surface, resulting in purulent and bleeding lesions. This case demonstrates the importance of appropriate training and competence in performing cosmetic procedures including injections and fat dissolving treatments. [ABSTRACT FROM AUTHOR]

Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mainly colonizes nasopharynx. In upper airways acute infections, e.g., the common cold, saline nasal irrigations have a significant efficacy in reducing symptoms. The present study aimed to test the efficacy of nasal lavages in upper airways symptoms of Coronavirus Disease 2019 (COVID-19). Methods: A series of consecutive adult subjects who tested positive for SARS-CoV-2 from December 2020 to February 2021 performed daily nasal lavages with saline solution (Lavonase®—Purling, Lugo di Romagna, Italy) for 12 days, starting on the day after the SARS-CoV-2 positive swab. A control group included a historical series of patients who were infected in February-March 2020 and who did not perform lavages. An ad hoc questionnaire regarding symptoms was administered to each subjects at base-line and 10 days after diagnosis (i.e., on the same day of the control swab) in both cases and controls. Results: A total of 140 subjects were enrolled. 68 participants in the treatment group and 72 in the control group were included. 90% of respondents declared the lavages were simple to use and 70% declared they were satisfied. Symptoms of blocked nose, runny nose, or sneezing decreased by an average of 24.7% after the treatment. Blocked nose and sneezing increased in the same period of time in the control group. Ears and eyes symptoms, anosmia/ageusia symptoms, and infection duration (10.53 days in the treatment group and 10.48 days in the control group) didn't vary significantly among the two groups. Conclusion: Nasal lavages resulted to significantly decrease nasal symptoms in newly diagnosed SARS-CoV-2 patients. These devices proved to be well-tolerated and easy to be used. Further studies on a larger number of subjects are needed in order to possibly confirm these preliminary results. [ABSTRACT FROM AUTHOR]

Understanding how hot (250°–350 °C) to super-hot (>350 °C) fluids circulate and interact with host rocks in fault-controlled upper continental crust is a challenging task. In this paper, we present the results of a structural, fluid inclusions, Sr isotope, petrographic and mineral study on an exhumed geothermal system to describe how hot to super-hot fluids were controlled by the increased permeability resulting from the interplay between low-angle normal faults and high-angle oblique-slip faults, the latter being part of a regional transfer zone. The study area is located on the eastern Elba Island (northern Tyrrhenian Sea, Italy), where the emplacement of a Messinian felsic intrusion has allowed hydrothermal fluids to circulate in relation to a fault-related permeability of the order of 10‐15 to 10‐13 m2. Magmatic fluids reacted with the host rocks (carbonate and phyllite) to form Fe-ore deposits hosted within the fault zones that controlled the fluid flow. Fluid inclusions trapped in quartz crystals indicate that the fluids consisted of saline solutions (salinity from 18.0 to 26.6 wt% NaCl eq.), which later mixed with low salinity waters of probably meteoric origin. The fluid temperature during the main hydrothermal stage ranged between about 300° and 360 °C under an estimated maximum hydrostatic pressure of 28–30 MPa. In contrast, the maximum possible temperature was about 400 °C at a lithostatic pressure of 89 MPa. The hydraulic breccias formed as a result of the transient fluid pressurisation up to lithostatic values, due to the self-sealing process and the subsequent pressure drop, down to hydrostatic values, as framed in the hydrofracturing processes. The results provide useful inputs for the identification of geothermal and ore-body targets in those geological settings where fluids of magmatic and meteoric origin are controlled by active faults in an extensional tectonic regime. • Hot to super-hot geothermal fluid migration through extensional fault zones. • Geometrical parameters from veins arrays and mineralised cataclasite provided hydraulic parameters of the palaeo-reservoir. • Hydrofracturing processes during fluid flow cause transient pressure drops. • Fluid inclusions analyses given information on temperature, salinity and origin of palaeo-fluids. [ABSTRACT FROM AUTHOR]

The article offers information on a study which examines the fluoride and chloride melt inclusions of phenocrysts from the magmatic rocks found in Pantelleria Island, Italy. The study uses the observation of saline globules in the melt inclusion glasses, the presentation of feldspar phenocrysts through the anorthoclase, and the partially crystallized melt inclusions. The study shows that the compositions and the behavior of fluoride and chloride melt inclusions are different from each other in terms of minerals, but have similarities in terms of rocks. Moreover, the study mentions that the complete melting of the materials was done from 740-760°C, while the complete homogenization of the inclusions was done from 930-1,020°C.

Objective: Electromotive drug administration (EMDA) presents a minimally invasive method of intravesical instillation of therapeutic agents without the need for general anesthesia.1 It employs a combination of iontophoresis, electrophoresis, and electroporation to deliver drugs into deep tissue layers using an electrical current created between 2 electrodes.2 This video shows feasibility of botulinum toxin type A (BoNTA) EMDA in myelomeningocele children with urinary incontinence secondary to neuropathic detrusor overactivity.Methods: In this technique (Video 1), catheterization was performed with a 10-Fr (CE-DAS, UROGENICS/Ag 9900 (pediatric), Mirandola, Italy) catheter electrode, after providing a local transurethral anesthesia with 2% lidocaine gel. The cuff of the catheter was filled by 2 cc saline solution. The bladder was then drained and irrigated with 0.9% saline solution until the catheter outflow became clear. The bladder was subsequently filled with sterile water to its maximal capacity. BoNTA (Dysport) at a dose of 10 IU/kg was added to the intravesical solution. Negative electrode as 2 dispersive electrodes was placed on the abdomen. Positive electrode was connected to the intravesical catheter. A pulsed current generator (Physionizer 30, Physion srl, Mirandola, Italy), delivered a current with frequency of 2,800 Hz, interval of 50 µs and amplitude of 10-20 mA for 20 minutes. At the end of the procedure, the bladder was emptied.Results: For the first time, BoNTA/EMDA was performed on myelomeningocele patients with urinary incontinence in our center.3 According to our prior reports, urinary incontinence improved in 75% of the patients between 2 consecutive clean intermittent catheterizations at 1-year follow-up.4 Mean maximal cystometric capacity significantly increased from 148 ± 62 mL at baseline to 239 ± 73 mL 1 year after the treatment.4 CONCLUSION: This technique is a feasible, safe, reproducible, cost effective, long lasting, and pain free method, on an outpatient basis with long-term duration of effects and without anesthesia or cystoscopy procedure. [ABSTRACT FROM AUTHOR]

In northern Italy, biomass burning-derived (BB) particles and diesel exhaust particles (DEP) are considered the most significant contributors to ultrafine particle (UFP) emission. However, a comparison between their impact on different brain regions was not investigated until now. Therefore, male BALB/c mice were treated with a single or three consecutive intratracheal instillations using 50 µg of UFPs in 100 µL of isotonic saline solution or 100 µL of isotonic saline solution alone, and brains were collected and analyzed. Proteins related to oxidative stress and inflammation, as well as Alzheimer's disease markers, were examined in the hippocampus, cerebellum, and the rest of the brain (RoB). Histopathological examination of the brain was also performed. Moreover, correlations among different brain, pulmonary, and cardiovascular markers were performed, allowing us to identify the potentially most stressful UFP source. Although both acute exposures induced inflammatory pathways in mouse brain, only DEP showed strong oxidative stress. The sub-acute exposure also induced the modulation of APP and BACE1 protein levels for both UFPs. We observed that DEP exposure is more harmful than BB, and this different response could be explained by this UFP's different chemical composition and reactivity. [ABSTRACT FROM AUTHOR]