1. ACE Gene Polymorphism and Insulin Action in Older Subjects and Healthy Centenarians.
- Author
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Paolisso, Giuseppe, Tagliamonte, Maria Rosaria, De Lucia, Domenico, Palmieri, Francesco, Manzella, Daniela, Rinaldi, Carmela, Bossone, Anna, Colaizzo, Donatella, Margaglione, Maurizio, and Varricchio, Michele
- Subjects
ANGIOTENSINS ,INSULIN resistance ,OLDER people - Abstract
OBJECTIVES: To evaluate the possible relationship between angiotensin-converting enzyme (ACE) insertion-deletion (ID) genotype and insulin resistance in a population of healthy older Italian subjects. DESIGN: Prospective recruitment of a convenience sample. PARTICIPANTS: One hundred twenty-five subjects age 62 to 105 in good health and not taking any drug known to interfere with glucose metabolism. RESULTS: In the sample population, the relative frequencies of the ACE genotypes deletion-deletion (DD) (0.424), ID (0.400), and insertion-insertion (II) (0.176) were not significantly different from values predicted by Hardy-Weinberg equilibrium. The genotype distribution was similar in men and women. Subjects carrying the II genotype had a higher FPG (P < .001) and FPI (P < .001) than did subjects with DD or ID genotype. Subjects with II genotype also had a significantly higher HOMA index than did subjects with DD or ID genotype (P for trend < .002). In a multivariate stepwise regression analysis, the ACE ID polymorphism was significantly and independently associated with the HOMA index (P < .001). The same result was confirmed performing multivariate analysis in the younger group and centenarians separately. [ABSTRACT FROM AUTHOR]
- Published
- 2001
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