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Background: Nowadays, Thoracic Surgery is technologically advanced; therefore, it also focuses its attention on nursing care. The aim of the study is to evaluate the effect of the assessment of a dedicated team of nurses (DTN) in all onco-hematological patients undergoing VATS lobectomy for lung cancer on the outcome of the patient, preventing pressure injuries, reducing perioperative stress, duration of operations, complications, and hospital stay times. Methods: We performed a single-center observational retrospective study, including 31 DTN and 760 onco-hematological patients who underwent thoracic surgery between 30 October 2018 and 30 June 2023 at "Vanvitelli" University of Naples. Results: DTN ensures good nursing care before, during, and after surgery. Operative time was reduced by approximately 20 min, decreasing hospital infections in the DNT period and reducing intraoperative complications such as bleeding and hospital costs (p < 0.05). Conclusions: Thoracic surgery nurses require more specialized training to adapt to the development of sophisticated. [ABSTRACT FROM AUTHOR]

In the last three decades, inclusive disability legislation has led to an increasing number of students with disabilities entering higher education. However, barriers to the full participation of students remain. This article presents evidence from studies conducted in two Italian universities. Drawing on the Capability Approach, the goal is to analyse the experiences of students with disabilities and to assess their capabilities in academic life. Participatory research methods were adopted using structured focus group discussion techniques. Fifty students with different types of disability participated in the study. Two major findings emerged from the data: (a) the essential value, in the experience of the students, of being able to use educational spaces, move around off campus and socialise with others; and (b) the tendency of capability achievements to vary according to context and type of disability, especially for students with visual disabilities, who experience relatively lower levels of mobility and respect.

Simple Summary: An ultrasound-guided percutaneous lung biopsy performed by a pulmonologist is a safe, minimally invasive procedure for patients with suspected lung malignancies, providing an excellent diagnostic yield for a comprehensive molecular profiling and programmed death ligand 1 testing. Moreover, ultrasound-guided percutaneous lung biopsy may represent a successful approach for diagnosis of lung lymphoid lesions, with potential implication on reducing time-to-treatment time. Background: The recent advances in precision oncology for lung cancer treatment has focused attention on the importance of obtaining appropriate specimens for tissue diagnosis as well as comprehensive molecular profiling. CT scan-guided biopsies and bronchoscopy are currently the main procedures employed for tissue sampling. However, growing evidence suggests that ultrasound-guided biopsies may represent an effective as well as safe approach in this diagnostic area. This study explores the safety and the diagnostic yield for cancer molecular profiling in ultrasound-guided percutaneous lung lesion biopsies (US-PLLB). Methods: One hundred consecutive patients with suspected lung cancer, between January 2021 and May 2024, who had ultrasound-guided lung biopsies have been retrospectively analyzed. Molecular profiling was conducted with next-generation sequencing Genexus using Oncomine precision assay or polymerase chain reaction according to specimen quality. Qualitative immunohistochemical assay of programmed death ligand 1 (PD-L1) expression was evaluated by the Dako PD-L1 immunohistochemistry 22C3 pharmDx assay. The co-primary endpoints were the molecular diagnostic yield and the safety profile of US-guided lung biopsies. Results: From January 2021 to May 2024, 100 US-guided lung biopsies were carried out and 95 were considered for inclusion in the study. US-PLLB provided informative tissue for a histological evaluation in 93 of 95 patients with an overall diagnostic accuracy of 96.84% [Sensitivity: 92.63%; Specificity: 96.84%; PPV: 100%; NPV: 100%]. Sixty-Six patients were diagnosed with NSCLC (69.47%) and were considered for molecular diagnostic yield evaluation and PD-L1 testing. Four patients had malignant lymphoid lesions. US-PLLB was not adequate to achieve a final diagnosis in three patients (3.16%). Complete molecular profiling and PD-L1 evaluation were achieved in all patients with adenocarcinoma (molecular diagnostic yield: 100%). PD-L1 evaluation was achieved in 28 of 29 patients (96.55%) with either SCC or NOS lung cancer. The overall complication rate was 9.47% (n = 9). Six patients (6.31%) developed pneumothorax, while three patients (3.16%) suffered mild haemoptysis without desaturation. Conclusions: According to our findings, US-guided lung biopsy is a safe, minimally invasive procedure in patients with suspected lung malignancies, providing an excellent diagnostic yield for both comprehensive molecular profiling and PD-L1 testing. In addition, our results suggest that US-guided biopsy may also be an effective diagnostic approach in patients with suspected lung lymphoma. [ABSTRACT FROM AUTHOR]

Educators have long sought how to prepare students to develop a global mind set and to work under conditions of complexity and uncertainty common in many world markets. The purpose of this study was to support educators in this cause by providing them with a "hands-on" exercise readily adaptable across the business curriculum to identify how culture shapes business concepts/practices of interest. Details are presented in a step-by-step procedure based upon a recognized "parallel-emic" research model developed to study cross-cultural differences to ensure analytical rigor. A Key-Word-In-Context (KWIC) indexing tool was employed to add precision and efficiency to the search process to help students readily identify common (etic-derived) and unique factors (emic-specific) shaping business concepts/practices cross-culturally.

The paper proposes the experimental characterization of a wall package made of geopolymer concrete and phase change materials (PCMs) in the climate of south Italy. Data collected from May to July 2021 were presented by elaborating surface temperatures and heat fluxes with the introduction of several new indices as the thermal stress reduction amplitude, the percentage of time in melting range and the extreme surface solicitations. The results indicate that the PCMs reduce the thermal solicitation and preserve the geopolymer blocks. The indoor surface temperature can be lowered also of 3°C during the hours with maximum sol-air temperatures and this could contribute to reduce the local discomfort phenomenon. Globally, the heat flux monitored on the geopolymer layer behind the PCM is attenuated and its trend is more regular; this reduction implies a reduction of heat gains through the opaque building envelope and finally a reduction of the energy demand. [ABSTRACT FROM AUTHOR]

When nature-based solutions (NBS) are developed with a primary scope, they also provide simultaneous additional economic, social, and environmental benefits, i.e., Ecosystem Services. A monetary assessment that accounts for these additional benefits is provided by this work, with a focus on Europe. Specifically, this is intended to evaluate nine identified benefits of those wetlands and buffer strips designed to primarily address agricultural diffuse pollution, which must surely be listed among the negative externalities of economic activities that NBS can help resolve. The aim of developing a simplified value transfer methodology for a rapid evaluation of NBS benefits with the adjusted unit Value Transfer method is to create an accessible solution when time, funding, or other constraints prevent the use of highly technical primary monetization approaches. The developed exercise allows us to gather insights from several primary valuation studies and to appropriately transfer the monetary valuation outcomes to new policy sites. In order to reduce the distance from the expected and required concrete achievements of the economic valuations, the study has been integrated with an case study located in the Venice lagoon catchment in Northwestern Italy. The results obtained are to be considered sound, with existing evidence showing that the most valuable benefits of the considered NBS are both water quality and recreation and tourism, to which is added, in the case of wetlands, water supply. [ABSTRACT FROM AUTHOR]

Introduction: Mismatch repair (MMR) deficiency represents a biomarker and therapeutic target in various neoplasms, but its role in biliary tract cancers (BTCs) remains misunderstood. Methods: MMR status was retrospectively assessed using immunohistochemistry in 163-BTCs patients. We identified MMR proficiency (pMMR)/deficiency (dMMR) according to the loss of MMR proteins (MLH1, PMS2, MSH2, MSH6). The primary objective of the study was to assess the incidence of dMMR in BTCs; the secondary purpose was to explore its association with prognosis and clinical features. Results: dMMR was recorded in 9 patients, and it was strongly associated with mucinous histology (p < 0.01). Regarding the prognostic effect, in 122-radically resected patients, disease-free survival (DFS) resulted significantly shorter in dMMR patients compared to pMMR patients (10.7 vs. 31.3 months, p = 0.025) and so did nodal status (48.2 vs. 15.3 months in N0 vs. N+) (p < 0.01). Moreover, dMMR confirmed its prognostic role in terms of DFS at multivariate analysis (p = 0.03), together with nodal status (p = 0.01), and resection margin (p = 0.03). In 103 M+ patients (encompassing 41 metastatic de novo and 62 recurred after surgery patients) there were not differences between dMMR and pMMR regarding survival analyses. Conclusions: dMMR status is strongly correlated with mucinous histology and represents an independent prognostic factor in terms of disease relapse in patients with resected BTC. Implications for Practice: MMR may play an independent role in promoting an aggressive behaviour in patients with radically resected BTC. These results could be useful in improving the selection of patients after resection and, above all, should justify the evaluation of MMR status as a therapeutic target in BTC, especially in patients with atypical histology. [ABSTRACT FROM AUTHOR]

For some years, the stone pine (Pinus pinea L.) forests of the Domitian coast in Campania, Southern Italy, have been at risk of conservation due to biological adversities. Among these, the pine tortoise scale Toumeyella parvicornis (Cockerell) has assumed a primary role since its spread in Campania began. Observation of pine forests using remote sensing techniques was useful for acquiring information on the health state of the vegetation. In this way, it was possible to monitor the functioning of the forest ecosystem and identify the existence of critical states. To study the variation in spectral behavior and identify conditions of plant stress due to the action of pests, the analysis of the multispectral data of the Copernicus Sentinel-2 satellite, acquired over seven years between 2016 and 2022, was conducted on the Domitian pine forest. This method was used to plot the values of individual pixels over time by processing spectral indices using Geographic Information System (GIS) tools. The use of vegetation indices has made it possible to highlight the degradation suffered by the vegetation due to infestation by T. parvicornis. The results showed the utility of monitoring the state of the vegetation through high-resolution remote sensing to protect and preserve the pine forest ecosystem peculiar to the Domitian coast. [ABSTRACT FROM AUTHOR]

Combining therapeutic patient education (TPE) with a medication review service could foster the adoption of appropriate lifestyles by patients and support care-providers in identifying strategies to improve the quality of prescribed care. This study aimed to identify barriers experienced by patients in managing their diseases and medication-related problems. This was a monocentric, case series, observational study involving home-care patients from the Local Health Authority ASL TO4. Patients were enrolled for a TPE intervention where drug therapies and patient habits were collected through narrative interviews. Medication review was performed to identify potentially inappropriate prescriptions (PIPs). Twenty patients (13 females) with a mean age of 74.7 years were enrolled. Patients had an average of 4.3 diseases and 80.0% of them were treated with ≥5 daily medications. The main PIPs involved ibuprofen, furosemide and pantoprazole. The qualitative analysis of the interviews identified seven macro-themes relating to different aspects of medication management: therapy; diseases; patient; patient journey; professionals; family and caregivers; drug information. The results of this study revealed some critical aspects related to the treatment path and healthcare professionals. These results will be used to plan educational interventions for polypharmacy patients to improve medication adherence and the understanding and management of diseases. [ABSTRACT FROM AUTHOR]

Background: Integrase inhibitor (INSTI) use has been associated with greater weight gain (WG) among people living with HIV (PLWH), but it is unclear how this effect compares in magnitude to traditional risk factors for WG. We assessed the population attributable fractions (PAFs) of modifiable lifestyle factors and INSTI regimens in PLWH who experienced a ≥5% WG over follow-up. Methods: In an observational cohort study from 2007 to 2019 at Modena HIV Metabolic Clinic, Italy, ART-experienced but INSTI-naive PLWH were grouped as INSTI-switchers vs non-INSTI. Groups were matched for sex, age, baseline BMI and follow-up duration. Significant WG was defined as an increase of ≥5% from 1st visit weight over follow-up. PAFs and 95% CIs were estimated to quantify the proportion of the outcome that could be avoided if the risk factors were not present. Results: 118 PLWH switched to INSTI and 163 remained on current ART. Of 281 PLWH (74.3% males), mean follow-up was 4.2 years, age 50.3 years, median time since HIV diagnosis 17.8 years, CD4 cell count 630 cells/µL at baseline. PAF for weight gain was the greatest for high BMI (45%, 95% CI: 27–59, p < 0.001), followed by high CD4/CD8 ratio (41%, 21–57, p < 0.001) and lower physical activity (32%, 95% CI 5–52, p = 0.03). PAF was not significant for daily caloric intake (−1%, −9-13, p = 0.45), smoking cessation during follow-up (5%, 0–12, p = 0.10), INSTI switch (11%, −19-36; p = 0.34). Conclusions: WG in PLWH on ART is mostly influenced by pre-existing weight and low physical activity, rather than switch to INSTI. [ABSTRACT FROM AUTHOR]

There are many existing buildings for which seismic rehabilitation interventions are required, especially in earthquake-prone areas like Italy. At the same time, the deep energy crisis that Europe is facing highlights the need for sustainable techniques that are able to increase the energy efficiency of buildings. In order to mitigate the social and cultural obstacles for deep renovations of buildings, effective techniques and methods are required to avoid relocating users, which often discourages such interventions. To this purpose and as the main novelty, this research is aimed at presenting a new strengthening technique for reinforced concrete buildings that is able to integrate structural seismic strengthening and energy efficiency improvements. It is made up of new framed structures connected from the outside to the existing building, thus reducing the intrusiveness and relocation needs of users. At the same time, the seismic strengthening technique is conceived for an optimal coupling with energy saving interventions like high-performance external insulation finishing systems. In this study, these techniques are described and applied to a reinforced concrete (RC) school building designed only for gravity loads, according to outdated standards. The results show that the considered strengthening technique increases the seismic performance of the building with respect to both life safety and damage limitation requirements, avoiding any further local interventions to the building's interior. On the other hand, the energy renovation allows for significant savings, since the resulting reduction in the total non-renewable energy consumption is larger than 80%. [ABSTRACT FROM AUTHOR]

In 2008, the Italian government passed a law that introduced a new school subject: Citizenship and Constitution. The law requires all students between the ages of 3 and 16 to attend almost 400 hrs. of Citizenship Education during their 13 years of compulsory schooling. The law is part of an increasingly wider international effort that focuses on improving pupils' knowledge of and involvement in society by exposing them to history and civic content. The aim of this article was to present a Citizenship Curriculum and its possible implementation in schools and other areas. Taking into account the Curriculum Transposition model, we propose both an External Transposition, which analyses international and national documents about Citizenship Education, and an Internal Transposition, in order to design a curriculum that will enable children to participate in decision-making processes and improve their complex thinking. The Implemented Citizenship Curriculum ("Poli§ophia" project) was introduced into the Municipal Council of Children, and the Philosophy for Children method was applied in order to help children make moral judgments, a fundamental component of democratic thinking.

Severe social withdrawal, including staying alone in one's bedroom, non-attendance at school or work, and minimal or absent social contacts, sometimes only through electronic devices, can be found in several psychiatric disorders, or in a 'primary' form, firstly defined in Japan as 'Hikikomori'. The distinction between primary and secondary forms is questionable, as it prevalently depends on the quality of psychiatric assessment. To date, few studies specifically explored Hikikomori in an adolescent population outside Japan. The aim of the present study is to describe clinical features of a consecutive group of 80 referred youth (13 to 18 years, 57 males) with social isolation, of which 40 were followed up on for 4–6 months, to characterize clinical features and outcome. All the participants presented psychiatric comorbid disorders, prevalently anxiety disorders, mood disorders, and autism spectrum disorder. Suicidality (ideation and behavior) was reported in 32.5% of the participants, and 20% of the participants attempted suicide. More than half of the participants exceeded the cut-off of the Internet Addiction Test, and 42.4% met the criteria for the Internet Gaming Disorder. At the follow-up appointment, an improvement of social withdrawal was reported in 75% of the sample; 67.5% of the participants significantly improved according to the CGI-improvement scale; and 55% of the participants had an improvement of functioning according to the C-GAS. Our findings suggest that Hikikomori is a transnosographic entity, with high rates of suicidality and Internet addiction, and that can it improve when it is timely diagnosed and treated. [ABSTRACT FROM AUTHOR]

Building energy requalification in Italy and Europe has been much discussed in recent years due to the high percentage of existing buildings with poor energy performance. In this context, it is useful to obtain a user-friendly and fast tool to predict the thermal energy demand (TED) for space conditioning and the related primary energy consumption (PEC) as a function of climatic stress. In this study, the SLABE methodology (simulation-based large-scale uncertainty/sensitivity analysis of building energy performance) is used to simulate representative Italian buildings, varying parameters such as geometry, envelope and HVAC (heating, ventilating and space conditioning) systems. MATLAB® in combination with EnergyPlus is used to analyze 200 buildings belonging to two structural types (multi-family buildings and apartment blocks) built in 1961–1975. Nine scenarios (as-built scenarios and eight retrofit ones) are investigated in 63 climatic locations. A regression analysis shows that the classical HDDs (heating degree days) approach cannot give an accurate prediction of TED because solar radiation is not accounted for. Thus, new climatic indices are developed alongside solar radiation, including the heating stress index (HSI), the cooling stress index (CSI) and the yearly climatic stress index (YCSI). The purpose of our work is to obtain climatic stress curves for the prediction of TED and PEC. Testing of this novel approach is performed by comparison with another building energy simulation tool, showing a low discrepancy, i.e., the coefficient of variation of the root mean square error is between 12% and 28%, which confirms certain reliability of the approach here proposed. [ABSTRACT FROM AUTHOR]

A first synthesis of available data for the period of Rome's expansion in Italy (about 400–29 b.c.e.) shows the role of climate and environment in early Roman imperialism. Although global indices suggest a warmer phase with relatively few short-term climate events occuring around the same time as the expansion, local data emphasize the highly variable timing and expression of these trends. This variability casts doubt on ideas of a unitary, historically consequential "Roman Warm Period." The historical importance of climate and environment to socioeconomic development merits emphasis, but should be understood in terms of evolving, contingent forms of resilience and risk-mitigating behavior by Italian communities during Roman expansion. [ABSTRACT FROM AUTHOR]

Different moderators/mediators of risk are involved in developmental dyslexia (DD), but data are inconsistent. We explored the prevalence of season of birth and its association with gender and age of school entry in an Italian sample of dyslexic children compared to an Italian normal control group. The clinical sample included 498 children (345 boys, mean age 10.3 [plus or minus] 2.1 years) with DD, the control sample 1,276 children (658 boys, mean age 10.8 [plus or minus] 2.2 years) from four elementary schools from the same urban area, and with the same socio-economic status level. A prevalence of birth in autumn was found among children with DD compared to controls (34% versus 24%, p less than 0.0001). Children with DD were more frequently males (p less than 0.0001) and had a lower mean age of school entry (p less than 0.0001). Regarding the distribution of ages, 11.4% of children with DD, but none of the subjects in the control group, started school before 5.7 years. Therefore, greater risk of DD was related to age of school entry (OR = 2.72), gender (OR = 2.16), and season of birth (OR = 1.21). Significant interactions between boys with DD born in autumn, and correct school of entry (OR = 2.56) were joint predictors of higher risk of DD. The association between birth in autumn and DD may be explained by the earlier age of school entry, which may be a critical element in the youngest children with DD or at risk to DD. Whether Italian school policy is oriented to anticipate the school entry, a closer detection of early learning disorders and associated risk factors (familial load, specific language disorders, and attention deficit hyperactivity disorder) should be warranted.

Objective: According to DSM-IV, bipolar disorders (BDs) include four subtypes, BD I, BD II, cyclothymic disorder, and BD not otherwise specified (NOS). We explore the clinical implications of this subtyping in a naturalistic sample of referred youths with BD I, BD II, and BD-NOS. Method: The sample consisted of 217 patients, 135 males and 82 females, ages between 8 and 18 years (mean age, 13.6 [+ or -] 2.9 years), diagnosed according to historical information, prolonged observations, and a structured clinical interview (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version). The location of the study was the Stella Maris Scientific Institute of Child Neurology and Psychiatry of Pisa (Italy). Results: Seventy-eight patients (35.9%) had BD I, 97 (44.7%) had BD II,and 42 (19.4%) had BD-NOS. Patients with BD I presented more frequently psychotic symptoms and elated rather than irritable mood. Patients with BD II were less severely impaired, presented more frequently depression as the intake affective episode, and had the highest comorbidity with anxiety disorders. Patients with BD-NOS presented an earlier onset of the disorder, a chronic rather than episodic course, an irritable rather than an elated mood, and a more frequent comorbidity with attention-deficit/hyperactivity disorder and oppositional defiant disorder. Conclusions: DSM-IV categorization of BD may have meaningful implications in youths, but needs to be detailed further. (Contains 3 tables.)

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Research dealing with the adoption of various precision agriculture technologies has shown that guidance and recording tools are more widespread than reactive ones (such as variable rate technology), with much lower utilization rates in European case studies. This study aims to analyze the propensity to innovate variable rate technologies among young Italian farmers. A cluster analysis was carried out revealing four groups. The first two groups represent non-adopters who think technological innovation is very complex from a technical point of view, as well as not very accessible as capital-intensive technology. The third and fourth groups represent adopters. The third reports an early level of adoption, still considering the cost of access a major barrier to technology implementation. The fourth, on the other hand, shows a more intensive level and considers the lack of institutional support a major limitation. The cluster with the most intensive adoption is characterized by the youngest age group, the farms with the largest size, and a prevalence of female entrepreneurs. The need for management training in day-to-day business operations upon adoption is detected for all groups. This paper identified relevant drivers and barriers in characterizing the adopting farm of variable rate technologies. Results may offer insights to the policy maker to better calibrate support interventions. [ABSTRACT FROM AUTHOR]

Simple Summary: We report an Italian multicentre study with the aim to reach a consensus based on the essential data to be included in the flow cytometry clinical report of patients with MM at diagnosis and after treatment. From the pre-analytical phase, through sample processing, data acquisition, analysis and evaluation of the potential limitations and pitfalls of the entire process, the study reaches a final conclusion shared by laboratories and clinicians according to the most up-to-date principles and recommendations. Flow cytometry is a highly sensitive and specific approach for discriminating between normal and clonal plasma cells in multiple myeloma. Uniform response criteria after treatment have been established by the International Myeloma Working Group and the EuroFlow Group; however, the way in which flow cytometry data are reported has suffered from no collaborative or multicentre efforts. This study, involving 8 expert laboratories and 12 clinical hematology units of the Lazio region in Italy, aims to produce a uniform and shared report among the various Centres. From the pre-analytical phase to sample processing, data acquisition, analysis, and evaluation of the potential limitations and pitfalls of the entire process, the study reaches a final conclusion shared by laboratories and clinicians according to the most updated principles and recommendations. The aim was to identify the necessary data to be included in the clinical report by using multiple-choice questionnaires at every single stage of the process. An agreement of more than 75% of the laboratories was considered mandatory for the data to be included in the report. By ensuring the operational autonomy of each laboratory, this study provides a clear report that limits subjective interpretations and highlights possible bias in the process, better supporting clinical decision-making. [ABSTRACT FROM AUTHOR]

In 2022, three antiviral drugs—molnupiravir, remdesivir and nirmatrelvir/ritonavir—were introduced for treatment of mild-to-moderate COVID-19 in high-risk patients. The aim of this study is the evaluation of their effectiveness and tolerability in a real-life setting. A single-center observational study was set up, with the involvement of 1118 patients, with complete follow-up data, treated between the 5th of January and the 3rd of October 2022 at Santa Maria Goretti's hospital in Latina, Central Italy. A univariable and a multivariable analysis were performed on clinical and demographic data and composite outcome, the persistence of symptoms at 30 days and time to negativization, respectively. The three antivirals showed a similar effectiveness in containing the progression of the infection to severe COVID-19 and a good tolerability in the absence of serious adverse effects. Persistence of symptoms after 30 days was more common in females than males and less common in patients treated with molnupiravir and nirmatrelvir/r. The availability of different antiviral molecules is a strong tool and, if correctly prescribed, they can have a significant role in changing the natural history of infection for frail persons, in which vaccination could be not sufficient for the prevention of severe COVID-19. [ABSTRACT FROM AUTHOR]

Alternaria alternata is one of the most devastating phytopathogenic fungi. This microorganism causes black spots in many fruits and vegetables worldwide, generating significant post-harvest losses. In this study, an A. alternata strain, isolated from infected pears (Pyrus communis) harvested in Italy, was characterized by focusing on its pathogenicity mechanisms and competitive exclusion in the presence of another pathogen, Botrytis cinerea. In in vitro assays, the fungus produces strong enzymatic activities such as amylase, xylanase, and cellulase, potentially involved during the infection. Moreover, it secretes four different toxins purified and identified as altertoxin I, alteichin, alternariol, and alternariol 4-methyl ether. Only alteichin generated necrotic lesions on host-variety pears, while all the compounds showed moderate to slight necrotic activity on non-host pears and other non-host fruit (lemon, Citrus limon), indicating they are non-host toxins. Interestingly, A. alternata has shown competitive exclusion to the competitor fungus Botrytis cinerea when co-inoculated in host and non-host pear fruits, inhibiting its growth by 70 and 65%, respectively, a result not observed in a preliminary characterization in a dual culture assay. Alteichin and alternariol 4-methyl ether tested against B. cinerea had the best inhibition activity, suggesting that the synergism of these toxins and enzymatic activities of A. alternata are probably involved in the competitive exclusion dynamics in host and non-host pear fruits. [ABSTRACT FROM AUTHOR]

Purpose: This study aims to examine the effects of board dynamics produced by reaching a certain proportion of women on board tasks (monitoring, strategy and advisory). Design/methodology/approach: Using a panel of 35 listed companies belonging to FTSE-MIB index, for the years 2008–2015, the hypotheses can be tested by applying random effect regressions. The introduction of gender board quota law in Italy has created a quasi-natural experiment that is applied in the study. Findings: This research provides evidence that reaching 33% women on boards, which is the threshold mandated by the Italian gender board quota law, makes a difference for strategy tasks but not for monitoring tasks. This proportion of women on boards creates the board dynamics necessary to empower all board members, allowing the varied knowledge, skills, backgrounds and personal qualities to be leveraged and used in strategy tasks. For monitoring tasks, obtaining a proportion of 20% women on boards, as a first threshold enforced by the law, is enough to voice their opinion during board meetings and challenge management. Originality/value: The results show that each set of board tasks requires different dynamics trigged by a specific proportion between a minority (women) and a dominant subgroup (men). To enhance monitoring tasks performance, it is enough to reach a proportion between men and women which makes the women less isolated and more inclined to speak up during the board meetings. In the case of strategy tasks, the improved performance is achieved when the dominant group enticed to hear women's opinions and responsive to various perspectives. This paper expands the debates going beyond monitoring tasks, showing the importance of board dynamics for engagement in strategy and advisory tasks. [ABSTRACT FROM AUTHOR]

Knowledge of the spatial distribution of European chestnut (Castanea sativa Mill.) cultivar diversity is essential for managing and conserving the genetic resources of this fruit tree species in Southern Italy. To this goal, the present work investigated the feasibility of mapping, through spatial representation, the distribution of genetic diversity of traditional chestnut varieties in the area of the Roccamonfina Regional Park in the Campania Region. After Principal Coordinates Analysis (PCoA) of molecular-genetic data, chestnuts formed varietal groups in a leopard spot on PCoA plots with a relatively high degree of genetic diversity. Successively, a Geographic Information System (GIS) tool utilized these molecular-genetic data to create a genetic divergence surface by geospatial interpolation on the geographic map of the Regional Park corresponding to each chestnut variety. The regions containing more biodiversity richness resulted in differentially colored from those containing cultivars less genetically distant from each other; thus, the area in study was consistently colored according to the allelic richness as evaluated by molecular-genetic markers. The combined use of tools for molecular and spatial analysis allowed for drafting genetic landscapes with the aim of extracting useful information for the safeguarding of the chestnut biodiversity at risk. [ABSTRACT FROM AUTHOR]

This paper deals with the role of geographical indications (GI) in the dairy sector of Italy, with the purpose of highlighting eventual negative dynamics in the adhesion to the GI by the potential operators of Italy. A negative adhesion to the GI circuit shows a "disaffection effect," and has relevant implications on sustainability on account of the role of a GI in boosting various dimensions of sustainability (economic, social, environmental). In order to verify the presence of a disaffection effect, an empirical analysis of the actors adhering to the GI dairy sector is carried out. Through the collection of secondary sources from official databases, the paper emphasises a negative trend in the adhesion to the GI dairy sector, which also reveals diversified territorial impacts. More precisely, unlike other sectors, the dairy sector reveals negative dynamics in the operators choosing to adhere to the GI circuits. The results of the analysis address some policy issues and solicit policy action to limit the disaffection effect on GI in the dairy sector. [ABSTRACT FROM AUTHOR]

Considering the large number of volatile molecules that characterize Cannabis sativa L., adequate investigation supported by the application of robust and effective analytical methods is essential to better understand the impact of these low- and medium-molecular-weight molecules on the entire phytocomplex. This work aimed to characterize the volatile fraction of the chemical profile of three different cultivars of Cannabis sativa L. pollen, grown in Italy, which were thoroughly investigated by the application of two complementary techniques: SPME-GC-MS and PTR-ToF-MS. Furthermore, in order to provide more information on the chemical profile of the matrices under study, the cannabinoid content of the hexane extracts was also measured by GC-MS. Until now, no similar study, in terms of survey techniques applied, has been performed on C. sativa pollen. The obtained results showed a high content of volatile molecules, which differentiated the three matrices. The data relating to the content of cannabinoids were also interesting as they showed that one of the three cultivars was richer than the others. Finally, an in-depth statistical survey was performed to better compare the investigated samples and identify the molecules that most contribute to differentiating them. The findings of this study may be useful for integrating the compositional information on C. sativa L. [ABSTRACT FROM AUTHOR]

In the present paper, a critical analysis of the 1980 Irpinia-Basilicata (southern Italy) postearthquake phase has been carried out, with particular attention to the Basilicata region. Post-earthquake policies were mainly addressed towards the physical reconstruction and socio-economic development of the affected areas. As for the development process, the expected results from the industrialisation and infrastructure works have been rather poor or indeed not achieved, mainly as a consequence of red tape, inefficiency and sometimes corruption events. On the other hand, impressive steps ahead have been made in terms of knowledge advancement concerning the assessment and reduction of seismic risk, with the creation of important education and research institutions in Basilicata. Furthermore, the relationship between earthquake disaster and territorial development has been examined, starting from some prominent studies proposed in the literature. The evolution of vulnerability levels to earthquakes of some countries around the world have been evaluated. Specifically, considering a time span of about 40 years (1980-2020), the data related to the number of deaths caused by earthquakes with respect to the population exposed has been analysed and some comparisons have been carried out. Although limited, since referring to a single risk indicator, the results confirm the close link between seismic consequences and socio-economic characteristics of the affected communities, as a poignant lesson for planning effective risk mitigation strategies. [ABSTRACT FROM AUTHOR]

The MIllimetric Sardinia radio Telescope Receiver based on Array of Lumped elements KIDs, MISTRAL, is a cryogenic W-band (77–103 GH) LEKID camera which will be integrated at the Gregorian focus of the 64 m aperture Sardinia Radio Telescope, in Italy, in Autumn 2022. This instrument, thanks to its high angular resolution ( ∼ 13 arcsec ) and the wide instantaneous field of view ( ∼ 4 arcmin ), will allow continuum surveys of the mm-wave sky with a variety of scientific targets, spanning from extragalactic astrophysics to solar system science. In this contribution, we will describe the design of the MISTRAL camera, with a particular focus on the optimisation and test of a prototype of the focal plane. [ABSTRACT FROM AUTHOR]

The adoption of innovations may boost the transition to sustainable agricultural models. Among these innovations, precision farming offers a fundamental contribution to sustainable soil management and the improvement in product quality. The work is set against this background and aims to analyse the rate of introducing precision farming tools and the variables that prevent/facilitate this adoption. Although adoption rates in Italy remain relatively low, it is vital to underline the obstacles that limit the broader use of precision agricultural technologies inside farms. To this end, the literature has highlighted various elements of complexity (farm characteristics, socio-economic and psychological), which can hinder or generate perceived complexity and significantly reduce the potential for technology adoption. In this context emerges the increasing importance of public and private activities related to knowledge transfer. The paper focuses on agricultural knowledge and innovation systems, which are also relevant in light of the recent proposal for the new regulation on rural development. The awareness–knowledge–adoption–product (AKAP) sequence was used to reveal the gap between the potential and actual adoption of innovation on Italian farms to comprehend the adoption process and identify relevant barriers and the role knowledge systems played. Empirical findings show that AKIS has a critical mediating function in promoting innovation uptake. Strengthening knowledge systems, acting on the different phases of the AKAP sequence, could allow a greater understanding of precision agriculture techniques and bottlenecks to adoption. [ABSTRACT FROM AUTHOR]

It is well known that the early removal of basal leaves is a viticultural practice adopted to improve the exposure of clusters to direct sunlight and UV radiation and increase the phenolic compounds and anthocyanin concentration in the berries. The aim of this work was to study the influence of early basal leaf removal on Aglianico wines produced in the Apulia region (southern Italy) during three consecutive seasons. Three vine treatments were carried out, where 100% of the cluster-zone leaves on the north, south and both sides of the canopy were removed. Undefoliated plants were used as a control. The effect of the treatments on the basic chemical parameters, phenol content and volatile composition of wines was investigated using WineScan FT-MIR, spectrophotometry, HPLC-DAD and SPME-GC/MS. Early defoliation increased the amounts of flavonoids (+35–40%), anthocyanins (+15–18%), total polyphenols (+10%), antioxidant activity (+8–14%) and colour intensity (+10%), especially when leaf removal was applied on the south side. Moreover, leaf removal led to a 40% increase in free anthocyanins when applied on the south side of the canopy, while a 24% increase was observed when applied to the north side and 21% when applied to the north and south sides. A negative effect was observed on volatile compounds, which decreased by about 18, 14 and 13% when the treatment was applied on the north, north-south and south sides of the canopy, respectively. In conclusion, early leaf removal treatments allow for the modulation of the phenolic and volatile concentrations of Aglianico wines. [ABSTRACT FROM AUTHOR]

Ten Amaryllidaceae alkaloids (AAs) were isolated for the first time from Pancratium maritimum collected in Calabria region, Italy. They belong to different subgroups of this family and were identified as lycorine, which is the main alkaloid, 9-O-demethyllycorine, haemanthidine, haemanthamine, 11-hydroxyvittatine, homolycorine, pancracine, obliquine, tazettine and vittatine. Haemanthidine was isolated as a scalar mixture of two 6-epimers, as already known also for other 6-hydroxycrinine alkaloids, but for the first time they were separated as 6,11-O,O′-di-p-bromobenzoyl esters. The evaluation of the cytotoxic and antiviral potentials of all isolated compounds was undertaken. Lycorine and haemanthidine showed cytotoxic activity on Hacat cells and A431 and AGS cancer cells while, pancracine exhibited selective cytotoxicity against A431 cells. We uncovered that in addition to lycorine and haemanthidine, haemanthamine and pancracine also possess antiretroviral abilities, inhibiting pseudotyped human immunodeficiency virus (HIV)−1 with EC50 of 25.3 µM and 18.5 µM respectively. Strikingly, all the AAs isolated from P. maritimum were able to impede dengue virus (DENV) replication (EC50 ranged from 0.34–73.59 µM) at low to non-cytotoxic concentrations (CC50 ranged from 6.25 µM to >100 µM). Haemanthamine (EC50 = 337 nM), pancracine (EC50 = 357 nM) and haemanthidine (EC50 = 476 nM) were the most potent anti-DENV inhibitors. Thus, this study uncovered new antiviral properties of P. maritimum isolated alkaloids, a significant finding that could lead to the development of new therapeutic strategies to fight viral infectious diseases. [ABSTRACT FROM AUTHOR]

Background: Lenvatinib has been approved in Italy since October 2019 as a first-line therapy for advanced hepatocellular carcinoma (HCC) and to date data on effectiveness and safety of lenvatinib are not available in our region. To fill this gap, we performed a multicentric analysis of the real-world treatment outcomes with the propensity score matching in a cohort of Italian patients with unresectable HCC who were treated with either sorafenib or lenvatinib. Aims and Methods: To evaluate the effectiveness of sorafenib and lenvatinib as primary treatment of advanced HCC in clinical practice we performed a multicentric analysis of the treatment outcomes of 288 such patients recruited in 11 centers in Italy. A propensity score was used to mitigate confounding due to referral biases in the assessment of mortality and progression-free survival. Results: Over a follow-up period of 11 months the Cox regression model showed 48% reduction of death risk for patients treated with lenvatinib (95% CI: 0.34– 0.81; p = 0.0034), compared with those treated with sorafenib. The median PFS was 9.0 and 4.9 months for lenvatinib and sorafenib arm, respectively. Patients treated with lenvatinib showed a higher percentage of response rate (29.4% vs 2.8%; p < 0.00001) compared with patients treated with sorafenib. Sorafenib was shown to be correlated with more HFSR, diarrhea and fatigue, while lenvatinib with more hypertension and fatigue. Conclusion: Our study highlighted for the first time the efficacy and safety of lenvatinib in an Italian cohort of patients. [ABSTRACT FROM AUTHOR]

Background: Hypoparathyroidism (HypoPT) or pseudo-hypoparathyroidism (pseudo-HypoPT) during pregnancy may cause maternal and fetal/neonatal complications. In this regard, only a few case reports or case series of pregnant or lactating women have been published. The purpose of this study was to describe clinical and biochemical course, pharmacological management, and potential adverse events during pregnancy and post-partum in pregnant women with HypoPT or pseudo-HypoPT. This was a retrospective, observational, multicenter, study involving nine Italian referral centers for endocrine diseases affiliated with the Italian Society of Endocrinology and involved in "Hypoparathyroidism Working Group".Results: This study identified a cohort of 28 women (followed between 2005 and 2018) with HypoPT (n = 25, 84% postsurgical, 16% idiopathic/autoimmune) and pseudo-HypoPT (n = 3). In HypoPT women, the mean calcium carbonate dose tended to increase gradually from the first to third trimester (+ 12.6%) in pregnancy. This average increase in the third trimester was significantly greater compared to the pre-pregnancy period (p value = 0.03). However, analyzing the individual cases, in 44% the mean calcium dosage remained unchanged throughout gestation. Mean calcitriol doses tended to increase during pregnancy, with a statistically significant increase between the third trimester and the pre-pregnancy period (p value = 0.02). Nevertheless, analyzing the individual cases, in the third trimester most women with HypoPT (64%) maintained the same dosage of calcitriol compared to the first trimester. Both mean calcium carbonate and calcitriol doses tended to decrease from the third trimester to the post-partum six months. Most identified women (~ 70%) did not display maternal complications and (~ 90%) maintained mean serum albumin-corrected total calcium levels within the low-to-mid normal reference range (8.5 ± 0.8 mg/dl) during pregnancy. The main complications related to pregnancy period included: preterm birth (n = 3 HypoPT women), and history of miscarriages (n = 6 HypoPT women and n = 2 pseudo-HypoPT women).Conclusion: This study shows that mean serum albumin-corrected total calcium levels were carefully monitored during pregnancy and post-pregnancy, with limited evaluation of other biochemical parameters, such as serum phosphate, 24 h urinary calcium, 25-OH vitamin D, and creatinine clearance. To avoid complications in mothers affected by (HypoPT) or (pseudo-HypoPT) and offspring, intense biochemical, clinical and pharmacological monitoring during pregnancy and breastfeeding is highly recommended. [ABSTRACT FROM AUTHOR]

Aim: To ascertain a delay in attendances to the emergency department (ED) during 2020 lockdown. Methods: Area‐based cohort study on paediatric (0‐15 years) attendances resulting in hospital admission in Tuscany, Italy, in February‐May 2020, and the corresponding periods in 2018‐19. We analysed times from symptom onset to arrival, the odds of arriving late (>90th centile of time) and paediatricians' judgements of a late presentation by logistic models. Results: As expected, ED attendance fell sharply (−62%) in 2020 vs 2018‐19. As for cases studied (455 in 2020 and 1161 in 2018–19), we documented a delay in arrival to the ED in 2020 versus 2018–19 for several groups of diagnoses, namely gastroenteritis, sepsis, wounds, burns and infections overall. Time to presentation over 90th centile was also higher in 2020 (odds ratio, OR: 1.44; 95% confidence interval: 1.00, 2.06), as were paediatricians' judgements of a late arrival (18.9% of cases in 2020 vs. 13.4% in 2018‐19; OR: 1.58; 1.14, 2.19) Conclusion: In a population‐based cohort, delayed attendances to ED ascertained both subjectively and objectively convey the message to families and to paediatricians to seek hospital care in case of severe or unremitting symptoms and not to wait longer than they normally would. [ABSTRACT FROM AUTHOR]

Grapevine trunk diseases (GTDs) are one of the most serious biotic stresses affecting this important crop. Among them a range of diseases were identified and associated to a plethora of phytopathogenic fungi, including species of Diaporthe. Diaporthe eres was recently identified as one of the species involved in cane blight of grapevine. The ability of a strain of this fungus isolated from infected grapevine plant in Italy to produce in vitro phytotoxic metabolites was investigated. Five phytotoxic metabolites were identified by their physical and spectroscopic properties as 4-hydroxybenzaldehyde, 4-hydroxybenzoic acid, nectriapyrone, p-cresol and tyrosol. When tested on grapevine leaf disks and by leaf absorption, 4-hydroxybenzoic acid induced symptoms on both disks and leaves, 4-hydroxybenzaldehyde and p-cresol showed, respectively, phytotoxicity on leaf disks and on the leaf absorption bioassay. [ABSTRACT FROM AUTHOR]

Bridges are essential for guaranteeing the functioning of transportation systems since their failure can cause serious threats to the safety, well-being and economy of modern communities, especially in emergency conditions. Following recent bridge failures, among which include the Morandi bridge in 2018, specific guidelines on risk classification and management, safety assessment and monitoring of existing bridges have been issued in Italy by the Minister of Infrastructure as a mandatory code. They pay particular attention to the evaluation of the residual life span of critical transportation infrastructure dating back to the 1950s and 1960s of the last century. Being a newly issued tool, the Guidelines need to be applied and tested in order to find possible drawbacks and to point out the main factors influencing their results. Therefore, in this study, after a short description of the Italian Guidelines, pointing out some differences with other approaches adopted worldwide, some advantages and disadvantages are discussed by an application to a bridge stock located in the Basilicata region (Italy). Data needed to apply the Guidelines are gathered by a purposely set up procedure that exploits existing databases on road infrastructure (OpenStreetMap) complemented by additional data retrieved by means of public image repositories (Google Street View). By accounting for the qualitative nature of the risk classification results obtained by applying the lower analysis levels of the Guidelines, a prioritization method is proposed for ranking bridges for higher assessment levels and possible interventions, as well as consequent funds allocation. The application shows that the Guidelines' approach tends to provide conservative results. In fact, even in case of bridges with low degradation levels, the final risk classification induces actions undertaken for preliminary or detailed assessment; thus, normal operation (with periodic inspections) would not be possible anymore. [ABSTRACT FROM AUTHOR]

We analyze the way in which individual academics and research groups organize their third mission activities before and after the institutionalization of third mission strategies by the university governing body. Drawing on the literature, we put forward an interpretative framework that links central entrepreneurial or engaged strategies with the way academics organize their third mission activities. Then, we propose an application of this frame to the case of the University of Florence (Italy), before and after its transition to more structured entrepreneurial and engaged models. We use a mix of quantitative and qualitative analysis. A cluster analysis allows identifying different types of academics involved in the third mission based on the way they organize their activities. Furthermore, a set of interviews to academics complements the comparison and the interpretation of the clusters obtained. The following paths of change emerge: (1) increased proportion of academics involved in third mission activities; (2) bottom-level initiatives that are aligned with central strategies; and (3) increased heterogeneity of bottom-level organization forms, with a relative loss of importance of the group dimension with respect to the individual academics and an increased specialization of research groups. [ABSTRACT FROM AUTHOR]

The paper deals with a highly seismic area located in the SW of the Basilicata region (southern Italy), along the valley of the Agri River. This area has a strategic role for Italy because about 70% of the Italian oil extraction derives from local deposits. Large quantities of oil have been extracted since the 1990s, making available large resources deriving from royalties. These sums of money could be used for an extensive strengthening program able to reduce the impact of future earthquakes. To this end, an action plan for the seismic risk mitigation of the residential building stock of 18 villages located in the Agri Valley is outlined, and specifically applied to the village of Viggiano. Starting from the available building-by-building inventory of the typological characteristics collected during previous research activities, the seismic vulnerability of the whole building stock is studied and the expected losses deriving from an earthquake scenario are determined. Some directions for an action plan, essentially based on the reduction of seismic vulnerability of buildings, are proposed in terms of needed costs and implementation timetables. [ABSTRACT FROM AUTHOR]

Background: The COVID-19 pandemic has posed several challenges to the provision of newborn nutrition and care interventions including maternal support, breastfeeding and family participatory care. Italy was the first country to be exposed to SARS-CoV-2 in Europe. One of the measures adopted by the Italian government during COVID-19 pandemic was the total lockdown of the cities with complete confinement at home. We aimed to examine the impact of the lockdown caused by COVID-19 pandemic on exclusive breastfeeding in non-infected mothers. Methods: We prospectively enrolled 204 mother-baby dyads during lockdown (9 March to 8 May 2020) that we compared to previously studied 306 mother-baby dyads admitted during the year 2018. To reduce the possible effect of confounding factors on exclusive breastfeeding, a 1:1 matching was performed by using an automatized procedure of stratification that paired 173 mother-baby dyads. Feeding modality was collected at discharge, 30 and 90 days of newborn's life. Exclusive breastfeeding was considered when the infant received only breast milk and no other liquids or solids were given with the exception of vitamins, minerals or medicines. Results: At discharge 69.4% of infants were exclusively breastfed during lockdown versus 97.7% of control group, 54.3% at 30 days vs 76.3 and 31.8% vs 70.5% at 90 days (p < 0.001). The proportion of breastfeeding remaining exclusive from discharge to 30-day was similar between groups (about 80%), but it was lower in lockdown group than in control cohort (58.5% vs 92.4%, p < 0.001) from 30- to 90-days. Conclusions: Lockdown and home confinement led to a decrease of exclusively breastfeeding in the studied population. Considering the timing to shift from exclusive to non-exclusive breastfeeding, differences between study groups were concentrated during hospital stay and from 30- to 90 days of a newborn's life, confirming that the hospital stay period is crucial in continuing exclusive breastfeeding at least for the first 30 days, but no longer relevant at 90 days of life. [ABSTRACT FROM AUTHOR]

Background: MEN1 is a complex, rare, syndrome inherited in an autosomal dominant tract and characterized by the development of multiple neuroendocrine tumors, requiring lifelong surveillance and multiple medical and surgical therapies throughout the patient's life. For all these reasons, a diagnosis of MEN1 can be a psychological shock for the patient, as well as his/her relatives, more so than the diagnosis of a single tumor. In the last two decades, clinicians have started to consider the emotional, psychological, relational, and social aspects of their patients' lives. The data collected in the present analyses highlight the unique features of MEN1 syndrome, and aim to evaluate the Quality of Life in the patients and their relatives. In this study, a comprehensive survey of various aspects of Health-Related Quality of Life was performed in a large series of Italian MEN1 patients, by administering five of the most common targeted questionnaires.Results: The results of the study showed that our patients, despite having a complex multi-tumor syndrome, were moderately optimistic (50%), and this corresponds with a normal Quality of Life. This positive response is strictly correlated with the fact that the patients are cared for at a dedicated Referral Center, receiving personalized care and constant follow-up, which gives them reassurance regarding the high quality of management of the disorder.Conclusions: The possibility of having access to a clinical Referral Center for their complex rare disease, together with the support of a dedicated patient association, has been demonstrated to be the ideal model for the management of post-diagnosis shock, and contributes to the preservation of a good Health-Related Quality of Life for MEN1 patients. [ABSTRACT FROM AUTHOR]

Poplar and willow demonstrate great potential for the phytoextraction of trace elements (TEs) from soils. In most cases, these species are managed as short-rotation coppice, producing high woody biomass yields, which could provide a valuable contribution toward reducing greenhouse gas emissions in the atmosphere. In the current study, we compared the TE extraction and CO2 sequestration rates in a four-year field trial in Southern Italy of two arboreal species (willow and poplar). The results show that, once established in the study area, willow extracted more Cd and Cu and less Pb than poplar. The two species demonstrated the same average Ni and Zn extraction rates. Greater biomass yields in poplar suggest that this species was able to fix greater amounts of CO2 (28.7 Mg ha−1 yr−1) than willow (24.9 Mg ha−1 yr−1). We argue that the choice of the species to be used in phytoextraction should first be made considering the TE-specific affinity and phytoextraction rates. For TEs whose extraction rates were the same (i.e., Ni and Zn), poplar is to be preferred because of its ability to fix greater amounts of CO2 than willow. [ABSTRACT FROM AUTHOR]

Soil organic matter (SOM) represents a main fraction of superficial soil characterized by a mechanical-hydrological behaviour different from that of the inorganic fractions. In this study, a method to measure the SOM content was applied to 27 selected sites in Tuscany (central Italy) characterized by the presence of soil types common in the region: cambisols and regosols. The method included the contribution from root fragments, which is a fraction often neglected or underestimated in measurements, in the overall estimate of the SOM content. The retrieved SOM contents were analysed considering the vegetation cover at the sites and the selected attributes of geological interest, such as geotechnical parameters and the mineralogical composition of the soils. The SOM normalized to the bulk samples ranges between 1.8 and 8.9% by weight, with the highest values of the SOM content being associated with vegetation cover classes of forest and woodlands without shrubs. The SOM values showed close relationships with the abundance of the finer fractions (silt and clay) of the soil samples, and considering the relations with geotechnical properties, moderate correlations were found with the plasticity index, unit weight and effective friction angle, overall demonstrating the importance of considering SOM when the geotechnical and hydrological properties of soils are evaluated. [ABSTRACT FROM AUTHOR]

In modern cities, the abundance of allergenic plant species has contributed to making less healthy the urban environment, as on-going and direct contact of humans with the urban flora can increase the negative effects on people allergic to pollens. The allergenicity of ornamental species should be considered, and above all quantified, when designing new urban green areas. Numerous studies reported the detailed description of the flora present in cities, but only in some rare cases their allergenic power and related pollen seasons were mentioned. In the present study, starting from the existing data in literature on the vascular flora of the Royal Park of Portici, Southern Italy, tree and shrub species have been classified based on their ability to cause respiratory allergies. Thus, to estimate the allergenic potential of urban green space, two preliminary approaches were defined based on the biological characteristics of the plant species as sources of pollen emissions. [ABSTRACT FROM AUTHOR]

Background: The standard approach for locally advanced rectal cancer (LARC) is neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision (TME). After nCRT 20% of patients achieve a clinical complete response (pCR) and could be treated with a non-operative management (NOM).Methods: The panel of the Italian Association of Medical Oncology (AIOM) Guidelines on rectal cancer applied the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach addressing the following question: Should NOM vs. TME be used for patients with rectal cancer with clinical complete response after nCRT? Five outcomes were identified: disease-free survival (DFS), mortality, local recurrence, colostomy rate, and functional outcomes.Results: Nine studies were included in the analysis. A higher risk of disease recurrence was observed in the NOM group compared to the TME group (RR = 1.69, 95% CI 1.08, 2.64) on the other hand, we observed a slightly positive but not significant effect on mortality of NOM (RR = 0.82, 95% CI 0.46, 1.45). Patients in the NOM group were more likely to experience local recurrence (RR = 5.37, 95% CI 2.56, 11.27) and patients in the TME group were more likely to have a permanent colostomy (RR = 0.15, 95% CI 0.08, 0.29). Only one study evaluated functional outcomes. The overall certainty of evidence was rated as very low.Conclusions: NOM was found to correlate with a higher risk of local recurrence which did not translate in worse OS and a lower colostomy rate. Due to the paucity of evidences, no recommendations are possible. NOM remains an experimental treatment; thus, patients managed with NOM should be enrolled in clinical trials with a dedicated follow-up schedule. [ABSTRACT FROM AUTHOR]

This study proposes a replicable approach for evaluating the impact of different weather data sources during the building refurbishment. Starting from a deep energy diagnosis, the numerical model is calibrated by using the weather data and the energy billings of the same year. Then, the performance gap is evaluated due to the adoption of conventional or new weather files defined with data recently monitored in areas with different levels of urbanization. The final step is a sensitivity analysis on the energy, environmental and economic indexes for the refurbishment interventions. The proposed approach is applied to the student dormitory of the University of Molise, located in Campobasso, a city of south Italy with oceanic climate according to Köppen classification. The results highlight significant deviations on the estimated energy consumption as well as on the energetic and environmental indexes of the refurbishment design. Instead, the impact on the economic index is quite limited. Highlights The weather data of rural and urban stations are compared with typical weather files. The UHI effect in heating-dominated climate in central Italy is proved. The mathematical relation between HDD/CCD and weather data evolution is found. The impact of different weather files on building energy performance prevision is studied. Inaccuracies in energy saving, environmental and economic indexes are quantified. [ABSTRACT FROM AUTHOR]

Background: In Italy, as in many European countries, Pediatric Emergency Medicine is not formally recognized as a pediatric subspecialty, hindering nation-wide adoption of standards of care, especially in the field of procedural sedation and analgesia (PSA) in the Emergency Department (ED). For this reason PSA in Italy is mostly neglected or performed very heterogeneously and by different providers, with no reference standard. We aimed to describe the procedures and results of the first multidisciplinary and multi-professional Consensus Conference in Italy on safe and effective pediatric PSA in Italian EDs. Methods: The preparation, organization and conduct of the Consensus Conference, held in Florence in 2017, followed the recommended National methodological standards. Professionals from different specialties across the country were invited to participate. Results: Overall 86 recommendations covering 8 themes (pre-sedation evaluation, pharmacologic agents, monitoring, equipment and discharge checklists, training, non-pharmacologic techniques, the adult ED setting, impact on hospitalizations) were developed, taking into account the Italian training system and healthcare organization characteristics. Conclusion: The results of the first multidisciplinary and multi-professional Consensus Conference in Italy are meant to provide up-to-date national guidance to improve the standard of care of children undergoing painful and stressful procedures in the ED. The recommendations will be periodically updated as new relevant evidence is published. [ABSTRACT FROM AUTHOR]

Macroseismic intensity data are an important source to learn from historical earthquakes. Nevertheless, this data needs to be converted into more suitable intensity measures to be used in risk analyses, as well as in design practice. To this purpose, in this paper, correlations between macroseismic scales and ground motion parameters have been derived. Peak Ground Acceleration (PGA), Peak Ground Velocity (PGV) and Housner Intensity (IH) as instrumental measures, and European Macroseismic Scale (EMS-98) and Mercalli-Cancani-Sieberg (MCS) as macroseismic measures, have been considered. 179 ground-motion records belonging to 32 earthquake events occurred in Italy in the last 40 years have been selected, provided that for each record, macroseismic intensity in terms of either EMS-98 or MCS or both were also available. Statistical analyses have been carried out to derive both direct (i.e. macroseismic vs instrumental intensity) and inverse (instrumental vs macroseismic intensity) relationships. Results obtained from the proposed relationships have been analyzed and compared with some of the most prominent results available in the technical literature. [ABSTRACT FROM AUTHOR]